公开(公告)号：US20170050121A1

公开(公告)日：2017-02-23

申请号：US15183526

申请日：2016-06-15

Applicant: GE Healthcare BioProcess R&D AB

Inventor： JAN BERGSTROM ,  GUNNAR GLAD ,  BO-LENNART JOHANSSON ,  JEAN-LUC MALOISEL ,  NILS NORRMAN ,  TOBIAS E. SODERMAN

IPC: B01D15/32 ,  B01J20/287 ,  C12N7/00 ,  G01N1/40 ,  C07K1/20 ,  C07K16/00 ,  B01J20/285 ,  B01J39/26

CPC classification number: B01D15/327 ,  B01J20/28009 ,  B01J20/285 ,  B01J20/287 ,  B01J20/3212 ,  B01J20/3293 ,  B01J39/26 ,  C07K1/20 ,  C07K16/00 ,  C12N7/00 ,  C12N2760/16151 ,  G01N1/405

Abstract: The present invention is within the field of chromatography. More precisely, it relates to a novel chromatography medium, namely a hydrophobic medium provided with different lids excluding molecules over a certain size due to the porosity of the hydrophobic medium and/or the porosity of the lid. The invention also relates to use of the separation medium for purification of large molecules, which do not enter the separation medium, as well as small molecules, which enter the separation medium and are eluted from there.

Abstract translation: 本发明在色谱领域内。 更准确地说，它涉及一种新颖的色谱介质，即由于疏水介质的孔隙率和/或盖的孔隙度，提供了不同盖子的疏水介质，其中排除了一定尺寸的分子。 本发明还涉及用于纯化不分离介质的大分子的分离介质以及进入分离介质并从其中洗脱的小分子的用途。