公开(公告)号：US11512140B2

公开(公告)日：2022-11-29

申请号：US16548883

申请日：2019-08-23

Applicant: GENMAB A/S

Inventor： Joost J. Neijssen ,  Bart De Goeij ,  Edward Norbert Van Den Brink ,  Aran Frank Labrijn ,  Rene Hoet ,  Janine Schuurman ,  Paul Parren ,  Jan Van De Winkel

IPC: C07K16/30 ,  G01N33/574 ,  A61P35/00 ,  A61K39/395 ,  C07K16/28 ,  A61K45/06 ,  C07K16/40 ,  A61K39/00

Abstract: Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.

公开(公告)号：US10351629B2

公开(公告)日：2019-07-16

申请号：US15072983

申请日：2016-03-17

Applicant: GENMAB A/S

Inventor： Janine Schuurman ,  Tom Vink ,  Jan Van De Winkel ,  Aran Frank Labrijn ,  Paul Parren ,  Willem Karel Bleeker ,  Frank Beurskens ,  Patrick Van Berkel

IPC: C07K16/00 ,  A61K39/00 ,  C12N15/85 ,  C07K16/28

Abstract: The invention relates to novel non-human transgenic animals, which upon antigenic stimulation are capable of producing monovalent antibodies binding to a selected antigen, modified heavy chain transgenes, methods for producing the non-human transgenic animals, methods for immunizing the non-human transgenic animals for as well as monovalent antibodies obtainable by such immunization methods.

公开(公告)号：US09492565B2

公开(公告)日：2016-11-15

申请号：US14854613

申请日：2015-09-15

Applicant: GENMAB A/S

Inventor： David Satijn ,  Sandra Verploegen ,  Wim Bleeker ,  Steen Lisby ,  Jan Van De Winkel ,  Patrick Van Berkel ,  Paul Parren

IPC: A61K39/395 ,  A61K47/48 ,  C07K16/36 ,  A61K45/06 ,  C07K16/30

CPC classification number: A61K47/48561 ,  A61K45/06 ,  A61K47/6817 ,  A61K47/6849 ,  C07K16/30 ,  C07K16/36 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92

Abstract: Antibody drug conjugates against tissue factor. Also disclosed are pharmaceutical compositions comprising the antibodies and antibody drug conjugates, and therapies and diagnostic methods for using the antibodies and antibody drug conjugates.

Abstract translation: 针对组织因子的抗体药物偶联物。 还公开了包含抗体和抗体药物共轭物的药物组合物，以及使用抗体和抗体药物偶联物的治疗和诊断方法。

公开(公告)号：US11046771B2

公开(公告)日：2021-06-29

申请号：US15832366

申请日：2017-12-05

Applicant: GENMAB A/S

Inventor： Bart De Goeij ,  Simone De Haij ,  Thilo Riedl ,  Rene Hoet ,  Ole Baadsgaard ,  Jan Van De Winkel ,  David Satijn ,  Paul Parren ,  Aran Frank Labrijn ,  Joyce Meesters ,  Janine Schuurman ,  Edward N. Van Den Brink

IPC: C07K16/28 ,  C07K16/32 ,  A61K39/00

Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.

公开(公告)号：US10906991B2

公开(公告)日：2021-02-02

申请号：US14934956

申请日：2015-11-06

Applicant: GENMAB A/S

Inventor： Janine Schuurman ,  Tom Vink ,  Jan Van De Winkel ,  Aran Frank Labrijn ,  Rob Aalberse ,  Marijn Van Der Neut Kolfschote ,  Paul Parren

IPC: C07K16/46 ,  C07K16/00 ,  C07K16/28

Abstract: The invention relates to an ex vivo method for the generation of a bispecific antibody, comprising the steps of: a) providing a first antibody having a first binding specificity, wherein said first antibody comprises an IgG4-like CH3 region, b) providing a second antibody having a second binding specificity which differs from said first binding specificity, wherein said second antibody comprises an IgG4-like CH3 region, c) incubating said first and second antibodies together under reducing conditions which allow the cysteines in the core hinge region to undergo disulfide-bond isomerization, and d) obtaining a bispecific antibody. The invention furthermore relates to bispecific antibodies obtainable by the method of the invention.

公开(公告)号：US20190169311A1

公开(公告)日：2019-06-06

申请号：US15998816

申请日：2018-08-16

Applicant: Genmab A/S

Inventor： Sandra Verploegen ,  David P.E. Satijn ,  Rene M.A. Hoet ,  Paul Parren ,  Jan Van De Winkel ,  Vibeke Miller Breinholt ,  Eva Ehrnrooth ,  Ole Baadsgaard ,  Tom Vink ,  Willem Karel Bleeker ,  Mischa Houtkamp ,  Maroeska Oudshoorn ,  Rob N. De Jong

IPC: C07K16/36 ,  A61K39/395

Abstract: Isolated human monoclonal antibodies which bind to human TF and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.

公开(公告)号：US20180319888A1

公开(公告)日：2018-11-08

申请号：US15977725

申请日：2018-05-11

Applicant: Genmab A/S

Inventor： Aran Frank Labrijn ,  Stefan Loverix ,  Paul Parren ,  Jan Van De Winkel ,  Janine Schuurman ,  Ignace Lasters

IPC: C07K16/28 ,  C07K16/00 ,  A61K47/68 ,  A61K51/10 ,  A61K39/395

CPC classification number: C07K16/2863 ,  A61K39/3955 ,  A61K47/6849 ,  A61K51/103 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/76

Abstract: The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of IgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.

公开(公告)号：US20150376282A1

公开(公告)日：2015-12-31

申请号：US14739768

申请日：2015-06-15

Applicant: Genmab A/S

Inventor： Aran Frank Labrijn ,  Stefan Loverix ,  Paul Parren ,  Jan Van De Winkel ,  Janine Schuurman ,  Ignace Laster

IPC: C07K16/28 ,  A61K47/48 ,  A61K51/10 ,  A61K39/395

CPC classification number: C07K16/2863 ,  A61K39/3955 ,  A61K47/6849 ,  A61K51/103 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/76

Abstract: The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of IgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.

Abstract translation: 本发明涉及抗体的恒定区，特别是IgG4的CH3区的位置，其影响了CH3-CH3相互作用的强度。 公开了稳定或不稳定这种相互作用的突变。

公开(公告)号：US20240084036A1

公开(公告)日：2024-03-14

申请号：US17972867

申请日：2022-10-25

Applicant: Genmab A/S

Inventor： Joost J. NEIJSSEN ,  Bart De Goeij ,  Edward Norbert Van Den Brink ,  Aran Frank Labrijn ,  Rene Hoet ,  Janine Schuurman ,  Paul Parren ,  Jan Van De Winkel

IPC: C07K16/30 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  C07K16/28 ,  C07K16/40 ,  G01N33/574

CPC classification number: C07K16/3076 ,  A61K39/3955 ,  A61K45/06 ,  A61P35/00 ,  C07K16/2863 ,  C07K16/40 ,  G01N33/5748 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/565 ,  C07K2317/71 ,  G01N2333/912

Abstract: Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.

公开(公告)号：US20220396629A1

公开(公告)日：2022-12-15

申请号：US17825202

申请日：2022-05-26

Applicant: GENMAB A/S

Inventor： Paul PARREN ,  Janine Schuurman ,  Tom Vink ,  Willem Karel Bleeker ,  Jan Van De Winkel ,  Patrick Van Berkel ,  Frank Beurskens

IPC: C07K16/28

Abstract: The present invention provides monovalent antibodies with a long half-life when administered in vivo, methods of making such monovalent antibodies, pharmaceutical compositions comprising such antibodies, and uses of the monovalent antibodies.