公开(公告)号：US20200316372A1

公开(公告)日：2020-10-08

申请号：US15733276

申请日：2018-12-11

Applicant: Galvani Bioelectronics Limited ,  UCL Business PLC

Inventor： Rizwan BASHIRULLAH ,  Gerald Edwin HUNSBERGER ,  Matteo DONEGA ,  Daniel CHEW ,  David Holder ,  Kirill ARISTOVICH

IPC: A61N1/05 ,  A61N1/36

Abstract: A nerve interface device including at least one cuff portion having an assembled position in which the cuff portion forms at least part of a passageway for receiving a nerve along a longitudinal axis passing through the passageway; and first and second rings of electrodes mounted on the at least one cuff portion, each ring of electrodes including a plurality of electrodes. Each electrode in the first ring has a corresponding longitudinally-aligned electrode in the second ring so as to form a plurality of pairs of electrodes spaced apart from each other along the longitudinal axis. The plurality of pairs of electrodes includes at least a first pair of electrodes, the first pair of electrodes mounted on the at least one cuff portion. The at least one cuff portion includes an asymmetric configuration about a central axis perpendicular to the longitudinal cuff axis.

公开(公告)号：US20240299737A1

公开(公告)日：2024-09-12

申请号：US18573365

申请日：2022-06-23

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： Rizwan BASHIRULLAH ,  Gerald Edwin HUNSBERGER

IPC: A61N1/05

CPC classification number: A61N1/0558

Abstract: Stents for intravascular neural stimulation are disclosed herein that at least partially contact a vessel wall. The stent comprises a scaffold extending in a longitudinal direction and having an outer perimeter that at least partially contacts the wall. A pulse generator can generate electrical signals for delivery to a nerve for intravascular neural stimulation. The scaffold has mounted thereon a first set of one or more electrodes electrically coupled to the pulse generator. The stent further comprises a second set of one or more electrodes electrically coupled to the pulse generator. The second set of electrodes is unconnected to the scaffold, i.e. not directly mounted on the scaffold. Methods of implanting a stent into a vessel using a deployment catheter are disclosed herein. The stent to be implanted comprises a pulse generator, a scaffold, and a distal set of one or more electrodes electrically coupled to the pulse generator. The distal set of electrodes is unconnected to the scaffold, i.e. not directly mounted on the scaffold. The method comprises positioning a distal end of the deployment catheter at the intravascular location, advancing the stent within the deployment catheter, further advancing the stent to expose the one or more electrodes of the distal set of one or more electrodes outside of, preferably beyond the deployment catheter, providing an electrical stimulation via the exposed electrodes, and withdrawing the stent within the deployment catheter.

公开(公告)号：US20240350808A1

公开(公告)日：2024-10-24

申请号：US18685989

申请日：2022-08-26

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： David Karl Lee PETERSON ,  Kevin KWONG ,  Gerald Edwin HUNSBERGER ,  Jason MIRANDA ,  Isha GUPTA ,  Paul MATTEUCCI ,  Daniel CHEW

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/08 ,  A61N1/375

CPC classification number: A61N1/3614 ,  A61N1/0556 ,  A61N1/36139 ,  A61N1/36142 ,  A61N1/36146 ,  A61N1/375 ,  A61N2001/083

Abstract: Systems for applying electrical stimulation to a nerve and determining a change in measured impedance or sensed electrical fields that is indicative of an electrical event, are disclosed herein. The system comprises an implantable housing comprising a signal generator, an implantable neural interface, an impedance measuring circuit or an electrical field sensing circuit, and processing circuitry. Methods for determining the presence of an electrical event in a system for applying electrical stimulation to a nerve, are also disclosed herein. The method comprises periodically sensing an impedance in an electrical pathway and determining an electrical event in the electrical pathway by identifying a change in the sensed impedance.

公开(公告)号：US20210069511A1

公开(公告)日：2021-03-11

申请号：US16771435

申请日：2018-12-11

Applicant: Galvani Bioelectronics Limited

Inventor： Gerald Edwin HUNSBERGER ,  Arun SRIDHAR

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/20

Abstract: Modulation of neural activity of a cardiac-related nerve at an interganglionic nerve branch in the sympathetic chain results in preferential reduction of sympathetic signals to the heart, thereby providing ways of treating and preventing cardiac dysfunction such as arrhythmias.

公开(公告)号：US20210093868A1

公开(公告)日：2021-04-01

申请号：US15733223

申请日：2018-12-11

Applicant: Galvani Bioelectronics Limited

Inventor： Gerald Edwin HUNSBERGER

IPC: A61N1/36 ,  A61N1/05

Abstract: There is provided a neural interface device for unidirectional stimulation of a nerve including at least one A-type nerve fiber or at least one at least partially myelinated nerve fiber. The device includes an electrode arrangement for placing on or around the nerve. The electrode arrangement includes a first electrode configured to be positively charged and a second electrode configured to be negatively charged, where the surface area of the second electrode is larger than the surface area of first electrode.

公开(公告)号：US20210069504A1

公开(公告)日：2021-03-11

申请号：US16771441

申请日：2018-12-11

Applicant: Galvani Bioelectronics Limited

Inventor： Gerald Edwin HUNSBERGER ,  Arun SRIDHAR

IPC: A61N1/36 ,  A61N1/05

Abstract: Modulation of neural activity of a ganglion, by applying a signal to a sympathetic nerve adjacent to the ganglion, results in preferential reduction of sympathetic signals to an effector, thereby providing ways of treating and preventing conditions associated with exacerbated sympatho-excitation.