公开(公告)号：US20230142770A1

公开(公告)日：2023-05-11

申请号：US18151004

申请日：2023-01-06

Applicant: GALVANI BIOELECTRONICS LIMITED ,  Université Côte d 'Azur ,  CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE

Inventor： Philippe Blancou ,  Nicolas GLAICHENHAUS ,  Arun SRIDHAR

IPC: A61N1/36

CPC classification number: A61N1/36139 ,  A61N1/36007 ,  A61N1/36157 ,  A61N1/36171 ,  A61N1/37211

Abstract: Devices and methods for the stimulation of neural signalling of an apical splenic nerve, the device having a transducer for placement on or around the apical splenic nerve, and a signal generator to generate a signal that stimulates or inhibits the neural activity of the apical splenic nerve to produce a physiological response. The transducer has at least one electrode, and the signal generator is a voltage or current source. The stimulation electrical signal has a frequency of between 1 Hz and 50 Hz.

公开(公告)号：US20190015675A1

公开(公告)日：2019-01-17

申请号：US16080143

申请日：2017-02-27

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： Alessandra GIAROLA ,  Arun SRIDHAR ,  Nicolas WISNIACKI

IPC: A61N2/00 ,  A61N5/06 ,  A61N7/00 ,  A61F7/00 ,  A61H7/00

Abstract: The present disclosure provides an apparatus or system and methods for treating xerostomia or Sjögren's Syndrome in a subject.

公开(公告)号：US20230381519A1

公开(公告)日：2023-11-30

申请号：US18158563

申请日：2023-01-24

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  Galvani Bioelectronics Limited

Inventor： Arun SRIDHAR ,  Stephen J. LEWIS ,  Ibrahim SALMAN

IPC: A61N1/36

CPC classification number: A61N1/36139 ,  A61N1/36117 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/36178

Abstract: Modulation of neural activity of a subject's aortic depressor nerve (ADN) and/or carotid sinus nerve (CSN) can modulate baroreceptor reflex function, thereby providing ways of treating or preventing disorders associated with malfunction or loss of the baroreceptor reflex.

公开(公告)号：US20210069511A1

公开(公告)日：2021-03-11

申请号：US16771435

申请日：2018-12-11

Applicant: Galvani Bioelectronics Limited

Inventor： Gerald Edwin HUNSBERGER ,  Arun SRIDHAR

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/20

Abstract: Modulation of neural activity of a cardiac-related nerve at an interganglionic nerve branch in the sympathetic chain results in preferential reduction of sympathetic signals to the heart, thereby providing ways of treating and preventing cardiac dysfunction such as arrhythmias.

公开(公告)号：US20200368531A1

公开(公告)日：2020-11-26

申请号：US16634252

申请日：2018-07-27

Applicant: GALVANI BIOELECTRONICS LIMITED ,  UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Arun SRIDHAR ,  Andrew C WEITZ ,  Victor Eugene PIKOV ,  Alessandra GIAROLA ,  Mark HUMAYUN

IPC: A61N1/36 ,  A61N1/05

Abstract: Modulation of neural signaling of an eye-related sympathetic nerve can decrease the levels of pro-inflammatory cytokines in the eye, and this provides a way of treating eye disorders, such as ocular neovascular diseases.

公开(公告)号：US20190262613A1

公开(公告)日：2019-08-29

申请号：US16348924

申请日：2017-11-10

Applicant: Galvani Bioelectronics Limited ,  Tokyo Metropolitan Institute of Gerontology

Inventor： Hans Jakob Kristoffer FAMM ,  Harumi HOTTA ,  Arun SRIDHAR

IPC: A61N1/36 ,  A61N5/06 ,  A61N7/02 ,  A61N1/05

Abstract: Modulation of neural activity in the superior laryngeal nerve (SLN) or cervical sympathetic trunk (CST) is effective in treating diseases and conditions mediated by thyroid and parathyroid hormones, in particular diseases associated with calcitonin secretion (e.g. osteoporosis) or diseases associated with thyroxine secretion (e.g. hypothyroid syndrome).

公开(公告)号：US20180043155A1

公开(公告)日：2018-02-15

申请号：US15551592

申请日：2016-02-19

Applicant: GALVANI BIOELECTRONICS LIMITED ,  HUNTINGTON MEDICAL RESEARCH INSTITUTES ,  UNIVERSITY OF CHILI

Inventor： Hans Jakob Kristoffer FAMM ,  Hernan E. LARA ,  Victor Eugene PIKOV ,  Arun SRIDHAR

IPC: A61N1/36 ,  A61F7/12 ,  A61N5/06 ,  A61N7/00 ,  A61N1/05 ,  A61N1/20

CPC classification number: A61N1/3606 ,  A61F7/12 ,  A61F2007/126 ,  A61N1/0551 ,  A61N1/20 ,  A61N1/36007 ,  A61N1/36135 ,  A61N5/0622 ,  A61N7/00 ,  A61N2005/063 ,  A61N2007/0026

Abstract: The present invention relates to medical devices and, more particularly, to medical devices that deliver neuromodulating therapy.

公开(公告)号：US20200246622A1

公开(公告)日：2020-08-06

申请号：US16643877

申请日：2018-09-14

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  Galvani Bioelectronics Limited

Inventor： Arun SRIDHAR ,  Stephen J. LEWIS ,  Ibrahim SALMAN

IPC: A61N1/36

Abstract: Modulation of neural activity of a subject's aortic depressor nerve (ADN) and/or carotid sinus nerve (CSN) can modulate baroreceptor reflex function, thereby providing ways of treating or preventing disorders associated with malfunction or loss of the baroreceptor reflex.

公开(公告)号：US20190290913A1

公开(公告)日：2019-09-26

申请号：US16347940

申请日：2017-11-08

Applicant: GALVANI BIOELECTRONICS LIMITED ,  UNIVERSITÉ DE NICE SOPHIA-ANTIPOLIS ,  CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE

Inventor： Philippe BLANCOU ,  Nicolas GLAICHENHAUS ,  Arun SRIDHAR

IPC: A61N1/36

Abstract: Stimulation of neural signalling of an apical splenic nerve can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating inflammatory disorders.

公开(公告)号：US20190201692A1

公开(公告)日：2019-07-04

申请号：US16302941

申请日：2017-05-19

Applicant: Galvani Bioelectronics Limited ,  The Johns Hopkins University

Inventor： Arun SRIDHAR ,  Liansheng LIU ,  Pankaj Jay PASRICHA

IPC: A61N1/36

CPC classification number: A61N1/36034 ,  A61N1/36017 ,  A61N1/3606 ,  A61N1/36085 ,  A61N1/36171

Abstract: A method for treating conditions associated with impaired glucose control, involving inhibition of signalling by the greater splanchnic nerve leads to a significant improvement in oral glucose tolerance.