公开(公告)号：US20240228463A1

公开(公告)日：2024-07-11

申请号：US18584311

申请日：2024-02-22

Applicant: Genentech, Inc.

Inventor： Marc KSCHONSAK ,  Steven John MCKERRALL ,  Daniel Fred ORTWINE ,  Jian Mehr-Dean PAYANDEH ,  Benjamin Douglas SELLERS ,  John C. TELLIS ,  Matthew VOLGRAF ,  Philippe BERGERON ,  Claudio CIFERRI ,  Peter Scott DRAGOVICH

IPC: C07D401/12 ,  A61K31/18 ,  A61P25/04 ,  C07C311/51 ,  C07D211/96 ,  C07D277/44 ,  C07D277/82 ,  C07D295/26 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

CPC classification number: C07D401/12 ,  A61K31/18 ,  A61P25/04 ,  C07C311/51 ,  C07D211/96 ,  C07D277/44 ,  C07D277/82 ,  C07D295/26 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

Abstract: The invention provides compounds of formulae I, II, IIa, and III:




and pharmaceutically acceptable salts thereof, as well as compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20230295273A1

公开(公告)日：2023-09-21

申请号：US18324406

申请日：2023-05-26

Applicant: Genentech, Inc.

Inventor： Claudio CIFERRI ,  Marc KSCHONSAK

IPC: C07K16/08 ,  C07K14/71 ,  C12N15/113 ,  A61P31/22

CPC classification number: C07K16/085 ,  C07K14/71 ,  C12N15/1133 ,  A61P31/22 ,  C07K2317/31 ,  C12N2310/11 ,  C12N2310/14

Abstract: Provided herein are methods of treating or preventing human cytomegalovirus (HCMV) infection comprising modulating interactions between the HCMV gHgLgO trimer and plasma membrane-expressed host cell proteins, as well as methods of identifying modulators of such interactions.

公开(公告)号：US20240094194A1

公开(公告)日：2024-03-21

申请号：US18518715

申请日：2023-11-24

Applicant: Genentech, Inc.

Inventor： Claudio CIFERRI ,  Evan Michael Green ,  Marc Kschonsak

IPC: G01N33/50 ,  G01N33/569

CPC classification number: G01N33/5091 ,  G01N33/56994 ,  C12N2503/00 ,  G01N2333/045 ,  G01N2469/10

Abstract: Provided herein are methods of treating or preventing human cytomegalovirus (HCMV) infection comprising modulating interactions between the HCMV gH/gL/UL128-131A pentamer and plasma membrane-expressed host cell proteins, as well as methods of identifying modulators of such interactions.