-
公开(公告)号：US20240239766A1
公开(公告)日：2024-07-18
申请号：US18584298
申请日：2024-02-22
申请人： Genentech, Inc.
发明人： Steven John MCKERRALL , Daniel Fred ORTWINE , Philippe BERGERON , Ramsay BEVERIDGE , Elise GHIRO , Kwong Wah LAI , Guqin SHI
IPC分类号： C07D401/12 , A61K31/454 , A61K31/506 , A61P17/04 , A61P29/00 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12
CPC分类号： C07D401/12 , A61K31/454 , A61K31/506 , A61P17/04 , A61P29/00 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12
摘要： The invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein Z1, Z2, R3-R8, RA, ring A, and n have the meanings described herein, and compositions containing such compounds and methods for using such compounds and compositions for the treatment of pain.
-
公开(公告)号：US20230279012A1
公开(公告)日：2023-09-07
申请号：US18069099
申请日：2022-12-20
申请人： Genentech, Inc.
IPC分类号： C07D487/04 , C07D487/14 , C07D471/04 , C07D471/14 , C07D495/04 , C07D519/00 , A61P37/00 , A61P35/00 , A61K31/496 , A61K31/4985 , A61K31/5025 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D495/14 , C07D498/04 , A61K31/4995 , A61K31/501 , C07D487/08 , C07D513/04 , A61K31/495 , A61K9/20
CPC分类号： C07D487/04 , C07D487/14 , C07D471/04 , C07D471/14 , C07D495/04 , C07D519/00 , A61P37/00 , A61P35/00 , A61K31/496 , A61K31/4985 , A61K31/5025 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D495/14 , C07D498/04 , A61K31/4995 , A61K31/501 , C07D487/08 , C07D513/04 , A61K31/495 , A61K9/20
摘要： Heteroaryl pyridone and aza-pyridone compounds are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using heteroaryl pyridone and aza-pyridone compounds for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
-
公开(公告)号：US20240270747A1
公开(公告)日：2024-08-15
申请号：US18523284
申请日：2023-11-29
申请人： Genentech, Inc.
IPC分类号： C07D487/04 , A61K9/20 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/4995 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K45/06 , A61P35/00 , A61P37/00 , C07D471/04 , C07D471/14 , C07D487/08 , C07D487/14 , C07D495/04 , C07D495/14 , C07D498/04 , C07D513/04 , C07D519/00
CPC分类号： C07D487/04 , A61K9/20 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/4995 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K45/06 , A61P35/00 , A61P37/00 , C07D471/04 , C07D471/14 , C07D487/08 , C07D487/14 , C07D495/04 , C07D495/14 , C07D498/04 , C07D513/04 , C07D519/00
摘要： Heteroaryl pyridone and aza-pyridone compounds are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using heteroaryl pyridone and aza-pyridone compounds for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
-
公开(公告)号：US20240228463A1
公开(公告)日：2024-07-11
申请号：US18584311
申请日：2024-02-22
申请人： Genentech, Inc.
发明人： Marc KSCHONSAK , Steven John MCKERRALL , Daniel Fred ORTWINE , Jian Mehr-Dean PAYANDEH , Benjamin Douglas SELLERS , John C. TELLIS , Matthew VOLGRAF , Philippe BERGERON , Claudio CIFERRI , Peter Scott DRAGOVICH
IPC分类号： C07D401/12 , A61K31/18 , A61P25/04 , C07C311/51 , C07D211/96 , C07D277/44 , C07D277/82 , C07D295/26 , C07D471/04 , C07D487/04 , C07D498/04
CPC分类号： C07D401/12 , A61K31/18 , A61P25/04 , C07C311/51 , C07D211/96 , C07D277/44 , C07D277/82 , C07D295/26 , C07D471/04 , C07D487/04 , C07D498/04
摘要： The invention provides compounds of formulae I, II, IIa, and III:
and pharmaceutically acceptable salts thereof, as well as compositions containing such compounds and methods for using such compounds and compositions.-
公开(公告)号：US20210079002A1
公开(公告)日：2021-03-18
申请号：US17001205
申请日：2020-08-24
申请人： Genentech, Inc.
IPC分类号： C07D487/04 , C07D487/14 , C07D471/04 , C07D471/14 , C07D495/04 , C07D519/00 , A61P37/00 , A61P35/00 , A61K31/496 , A61K31/4985 , A61K31/5025 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D495/14 , C07D498/04 , A61K31/4995 , A61K31/501 , C07D487/08 , C07D513/04 , A61K31/495 , A61K9/20
摘要： Heteroaryl pyridone and aza-pyridone compounds are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using heteroaryl pyridone and aza-pyridone compounds for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
-
公开(公告)号：US20200062769A1
公开(公告)日：2020-02-27
申请号：US16670898
申请日：2019-10-31
申请人： Genentech, Inc.
IPC分类号： C07D487/04 , A61K9/20 , A61K31/495 , C07D513/04 , C07D487/08 , A61K31/501 , A61K31/4995 , C07D498/04 , C07D495/14 , A61K45/06 , A61K31/5383 , A61K31/5377 , A61K31/53 , A61K31/506 , A61K31/5025 , A61K31/4985 , A61K31/496 , C07D519/00 , C07D495/04 , C07D471/14 , C07D471/04 , C07D487/14 , A61P35/00 , A61P37/00
摘要： Heteroaryl pyridone and aza-pyridone compounds are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using heteroaryl pyridone and aza-pyridone compounds for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.032 秒)
