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公开(公告)号：US11130819B2
公开(公告)日：2021-09-28
申请号：US17228023
申请日：2021-04-12
Applicant: GENMAB A/S
Inventor： David Satijn , Esther C. W. Breij , Bart E. C. G. De Goeij , Kristel Kemper , Patrick Engelberts , Edward N. Van Den Brink , Rik Rademaker , Dennis Verzijl , Sjeng Horbach , Paul Parren
Abstract: The present invention relates to antibodies binding to 5T4, including bispecific antibodies binding to 5T4 and CD3. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.
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公开(公告)号：US20240392032A1
公开(公告)日：2024-11-28
申请号：US18617483
申请日：2024-03-26
Applicant: Genmab A/S
Inventor： David SATIJN , Esther C.W. Breij , Bart E.C.G. De Goeij , Kristel Kemper , Patrick Engelberts , Edward N. Van Den Brink , Rik Rademaker , Dennis Verzijl , Sjeng Horbach , Paul Parren
Abstract: The present invention relates to antibodies binding to 5T4, including bispecific antibodies binding to 5T4 and CD3. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.
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公开(公告)号：US11970544B2
公开(公告)日：2024-04-30
申请号：US17353087
申请日：2021-06-21
Applicant: GENMAB A/S
Inventor： David Satijn , Esther C. W. Breij , Bart E. C. G. De Goeij , Kristel Kemper , Patrick Engelberts , Edward N. Van Den Brink , Rik Rademaker , Dennis Verzijl , Sjeng Horbach , Paul Parren
CPC classification number: C07K16/30 , A61P35/00 , C12N15/79 , A61K2039/505 , C07K2317/31 , C07K2317/51 , C07K2317/565
Abstract: The present invention relates to antibodies binding to 5T4, including bispecific antibodies binding to 5T4 and CD3. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.
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公开(公告)号：US20230027394A1
公开(公告)日：2023-01-26
申请号：US17739934
申请日：2022-05-09
Applicant: GENMAB A/S
Inventor： Rik RADEMAKER , Isil Altintas , Patrick Engelberts , Janine Schuurman , Paul Parren
Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
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公开(公告)号：US20230132049A1
公开(公告)日：2023-04-27
申请号：US17938523
申请日：2022-10-06
Applicant: GENMAB A/S
Inventor： David SATIJN , Patrick Engelberts , Kristel Kemper , Esther C.W. Breij , Simone OOSTINDIE , Farshid ALEMDEHY
Abstract: The invention relates to multispecific antibodies binding to CD3 and CD30. The invention further provides pharmaceutical compositions comprising antibodies of the invention, nucleic acids encoding the antibodies, host cells that produce the antibodies, methods of producing the antibodies and uses of the antibodies, in particular for cancer therapy.
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Patent Agency Ranking
公开(公告)号：US10544220B2
公开(公告)日：2020-01-28
申请号：US15541594
申请日：2016-01-08
Applicant: GENMAB A/S
Inventor： Patrick Engelberts , Esther Breij , Rik Rademaker , Isil Altintas , David Satijn , Sandra Verploegen , Riemke Van Dijkhuizen Radersma , Edward Van Den Brink , Janine Schuurman , Paul Parren
IPC: C07K16/28 , C07K16/30 , A61K39/395 , A61K39/00
Abstract: Bispecific antibodies directed to CD3 and CD20 and uses of such bispecific antibodies, in particular use thereof in the treatment of diseases in which specific targeting and T cell-mediated killing of cells that express CD20 is desired.
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公开(公告)号：US11814437B2
公开(公告)日：2023-11-14
申请号：US17938523
申请日：2022-10-06
Applicant: GENMAB A/S
Inventor： David Satijn , Patrick Engelberts , Kristel Kemper , Esther C. W. Breij , Simone Oostindie , Farshid Alemdehy
CPC classification number: C07K16/2878 , A61P35/00 , C07K16/2809 , C12N15/63 , C07K2317/31 , C07K2317/526 , C07K2317/565
Abstract: The invention relates to multispecific antibodies binding to CD3 and CD30. The invention further provides pharmaceutical compositions comprising antibodies of the invention, nucleic acids encoding the antibodies, host cells that produce the antibodies, methods of producing the antibodies and uses of the antibodies, in particular for cancer therapy.
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公开(公告)号：US11359015B2
公开(公告)日：2022-06-14
申请号：US15744317
申请日：2016-07-14
Applicant: GENMAB A/S
Inventor： Rik Rademaker , Isil Altintas , Patrick Engelberts , Janine Schuurman , Paul Parren
Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
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公开(公告)号：US11261254B1
公开(公告)日：2022-03-01
申请号：US17494545
申请日：2021-10-05
Applicant: GENMAB A/S
Inventor： Louise Koopman , Patrick Engelberts , Dennis Verzijl , Edward N. Van Den Brink , Rik Rademaker , Sieto Bosgra , Frederikke L. Egerod , David Satijn , Esther C. W. Breij
Abstract: The present invention relates to antibodies binding to B7H4, including bispecific antibodies binding to B7H4 and CD3. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.
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公开(公告)号：US11008399B2
公开(公告)日：2021-05-18
申请号：US17077376
申请日：2020-10-22
Applicant: GENMAB A/S
Inventor： David Satijn , Esther C. W. Breij , Bart E. C. G. De Goeij , Kristel Kemper , Patrick Engelberts , Edward N. Van Den Brink , Rik Rademaker , Dennis Verzijl , Sjeng Horbach , Paul Parren
Abstract: The present invention relates to antibodies binding to 5T4, including bispecific antibodies binding to 5T4 and CD3. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.
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