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公开(公告)号：US20220348890A1
公开(公告)日：2022-11-03
申请号：US17605499
申请日：2020-04-24
Applicant: Genomatica, Inc.
Inventor： Amit M. Shah , Harish Nagarajan , Joseph Roy Warner , Russell Scott Komor
Abstract: Disclosed are transaminase (TA) enzymes and nucleic acids encoding them. In some cases, the transaminase enzymes are non-natural, engineered transaminases. Also disclosed are biosynthetic methods and engineered microorganisms that enhance or improve the biosynthesis of 6-aminocaproate, hexamethylenediamine, caproic acid, caprolactone, or caprolactam. The engineered microorganisms include exogenous TA and in some cases engineered TA.
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公开(公告)号：US20220333142A1
公开(公告)日：2022-10-20
申请号：US17605120
申请日：2020-04-24
Applicant: Genomatica, Inc.
Inventor： Amit M. Shah , Harish Nagarajan , Michael Angus Noble
Abstract: Disclosed are trans-enoyl CoA reductase (TER) enzymes and nucleic acids encoding them. In some cases, the TER enzymes are non-natural, engineered trans-enoyl CoA reductase. TER enzymes were shown to catalyse the conversion of 5-carboxy-2-pentenoyl-CoA into adipyl-CoA for improved adipate production and the conversion of crotonyl-CoA into 6-aminocaproate. The enzymes can be used in biosynthetic methods and engineered microorganisms that enhance or improve the biosynthesis of 6-aminocaproate, hexamethylenediamine, caproic acid, caprolactone, or caprolactam. The engineered microorganisms include exogenous TER and in some cases engineered TER.
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公开(公告)号：US20220235385A1
公开(公告)日：2022-07-28
申请号：US17605196
申请日：2020-04-24
Applicant: Genomatica, Inc.
Inventor： Amit M. Shah , Harish Nagarajan
Abstract: Disclosed are biosynthetic methods and engineered microorganism that enhance or improve the biosynthesis of hexamethylenediamine, caproic acid or caprolactam. The engineered microorganisms include selected aldehyde dehydrogenase activity.
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