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    B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION
    1.
    发明申请
    B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION 审中-公开
    B7相关核酸和多肽可用于免疫调节

    公开(公告)号：US20140194598A1

    公开(公告)日：2014-07-10

    申请号：US14178360

    申请日：2014-02-12

    申请人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    发明人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    IPC分类号： C07K14/705 ,  C07K16/28 ,  A61K47/48

    CPC分类号： C07K14/70532 ,  A61K38/00 ,  C07K16/2827 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  Y10S435/81

    摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

    摘要翻译： 本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。 还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。 本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。 此外，本发明提供利用B7相关核酸，多肽或肽的测定法。 本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

    B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION
    2.
    发明申请
    B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION 有权
    B7相关核酸和多肽可用于免疫调节

    公开(公告)号：US20100136575A1

    公开(公告)日：2010-06-03

    申请号：US12701119

    申请日：2010-02-05

    申请人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    发明人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    IPC分类号： G01N33/53 ,  C07K16/00 ,  C12N5/16

    CPC分类号： C07K14/70532 ,  A61K38/00 ,  C07K16/2827 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  Y10S435/81

    摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

    摘要翻译： 本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。 还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。 本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。 此外，本发明提供利用B7相关核酸，多肽或肽的测定法。 本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

    BSL3 polypeptides
    3.
    发明授权
    BSL3 polypeptides 有权
    BSL3多肽

    公开(公告)号：US07723479B2

    公开(公告)日：2010-05-25

    申请号：US11900026

    申请日：2007-09-06

    申请人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    发明人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    IPC分类号： C07K14/705

    CPC分类号： C07K14/70532 ,  A61K38/00 ,  C07K16/2827 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  Y10S435/81

    摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

    摘要翻译： 本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。 还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。 本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。 此外，本发明提供利用B7相关核酸，多肽或肽的测定法。 本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

    B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION
    4.
    发明申请
    B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION 有权
    B7相关核酸和多肽可用于免疫调节

    公开(公告)号：US20120329990A1

    公开(公告)日：2012-12-27

    申请号：US13331540

    申请日：2011-12-20

    申请人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    发明人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    IPC分类号： C07K14/435 ,  C07H21/04

    CPC分类号： C07K14/70532 ,  A61K38/00 ,  C07K16/2827 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  Y10S435/81

    摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

    摘要翻译： 本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。 还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。 本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。 此外，本发明提供利用B7相关核酸，多肽或肽的测定法。 本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

    B-7 related nucleic acids and polypeptides useful for immunomodulation
    5.
    发明申请
    B-7 related nucleic acids and polypeptides useful for immunomodulation 有权
    可用于免疫调节的B-7相关核酸和多肽

    公开(公告)号：US20090215995A1

    公开(公告)日：2009-08-27

    申请号：US11900026

    申请日：2007-09-06

    申请人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N, Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    发明人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N, Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    IPC分类号： C07K19/00 ,  C07K14/47

    CPC分类号： C07K14/70532 ,  A61K38/00 ,  C07K16/2827 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  Y10S435/81

    摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

    摘要翻译： 本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。 还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。 本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。 此外，本发明提供利用B7相关核酸，多肽或肽的测定法。 本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

    Strain relief device for an electrical cable
    9.
    发明授权
    Strain relief device for an electrical cable 失效
    用于电缆的应变消除装置

    公开(公告)号：US6068506A

    公开(公告)日：2000-05-30

    申请号：US63677

    申请日：1998-04-21

    申请人： Henry Shen

    发明人： Henry Shen

    IPC分类号： H01R13/56 ,  H01R13/58

    CPC分类号： H01R13/562 ,  H01R13/5845

    摘要： A strain relief device is adapted to be interposed between an end portion of an electrical cable and an electrical connector. The strain relief device includes a sheath which is adapted to be injection molded on the cable and which is adapted to be held on the connector. A rigid sleeve has an enlarged inner end portion and an enlarged outer end portion, and is adapted to be interposed between the sheath and the cable in such a manner that a connecting end portion of the cable is press fitted within the enlarged inner end portion of the sleeve, and that the sheath is injection molded on the assembly of the cable and the sleeve. The enlarged inner and outer end portions of the sleeve define an annular groove therebetween in an outer surface of the sleeve. The sheath has an inward flange which projects radially and inwardly therefrom to engage fittingly the annular groove in the sleeve, thereby preventing removal of the sleeve and the cable from the sheath.

    摘要翻译： 应变消除装置适于插入在电缆的端部和电连接器之间。 应变消除装置包括适于在电缆上注射成型并且适于保持在连接器上的护套。 刚性套筒具有扩大的内端部分和扩大的外端部分，并且适于插入在护套和电缆之间，使得电缆的连接端部压配合在扩大的内端部 套筒，并且护套被注塑在电缆和套筒的组件上。 套筒的扩大的内端部和外端部在套筒的外表面中间形成环形槽。 护套具有向内突出的凸出部，其向内突出并向内突出以将套筒中的环形凹槽配合接合，从而防止套筒和电缆从护套上移除。