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    B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION
    1.
    发明申请
    B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION 审中-公开
    B7相关核酸和多肽可用于免疫调节

    公开(公告)号：US20140194598A1

    公开(公告)日：2014-07-10

    申请号：US14178360

    申请日：2014-02-12

    申请人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    发明人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    IPC分类号： C07K14/705 ,  C07K16/28 ,  A61K47/48

    CPC分类号： C07K14/70532 ,  A61K38/00 ,  C07K16/2827 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  Y10S435/81

    摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

    摘要翻译： 本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。 还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。 本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。 此外，本发明提供利用B7相关核酸，多肽或肽的测定法。 本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

    B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION
    2.
    发明申请
    B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION 有权
    B7相关核酸和多肽可用于免疫调节

    公开(公告)号：US20100136575A1

    公开(公告)日：2010-06-03

    申请号：US12701119

    申请日：2010-02-05

    申请人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    发明人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    IPC分类号： G01N33/53 ,  C07K16/00 ,  C12N5/16

    CPC分类号： C07K14/70532 ,  A61K38/00 ,  C07K16/2827 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  Y10S435/81

    摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

    摘要翻译： 本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。 还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。 本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。 此外，本发明提供利用B7相关核酸，多肽或肽的测定法。 本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

    BSL3 polypeptides
    3.
    发明授权
    BSL3 polypeptides 有权
    BSL3多肽

    公开(公告)号：US07723479B2

    公开(公告)日：2010-05-25

    申请号：US11900026

    申请日：2007-09-06

    申请人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    发明人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    IPC分类号： C07K14/705

    CPC分类号： C07K14/70532 ,  A61K38/00 ,  C07K16/2827 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  Y10S435/81

    摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

    摘要翻译： 本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。 还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。 本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。 此外，本发明提供利用B7相关核酸，多肽或肽的测定法。 本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

    B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION
    4.
    发明申请
    B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION 有权
    B7相关核酸和多肽可用于免疫调节

    公开(公告)号：US20120329990A1

    公开(公告)日：2012-12-27

    申请号：US13331540

    申请日：2011-12-20

    申请人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    发明人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    IPC分类号： C07K14/435 ,  C07H21/04

    CPC分类号： C07K14/70532 ,  A61K38/00 ,  C07K16/2827 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  Y10S435/81

    摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

    摘要翻译： 本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。 还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。 本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。 此外，本发明提供利用B7相关核酸，多肽或肽的测定法。 本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

    Identification and cloning of a novel human gene, RET16, involved in the intracellular signaling cascade
    7.
    发明授权
    Identification and cloning of a novel human gene, RET16, involved in the intracellular signaling cascade 失效
    鉴定和克隆参与细胞内信号传导级联的新型人基因RET16

    公开(公告)号：US07678887B2

    公开(公告)日：2010-03-16

    申请号：US11705672

    申请日：2007-02-13

    申请人： Charles G. Todderud ,  Joshua N. Finger ,  Jill Rillema

    发明人： Charles G. Todderud ,  Joshua N. Finger ,  Jill Rillema

    IPC分类号： A61K51/00 ,  G01N33/566 ,  C07K1/00

    CPC分类号： C07K14/47

    摘要： The present invention describes a newly discovered polynucleotide encoding a protein involved in the cell signaling cascade, called RET16, cloned, isolated and identified from TNF-alpha stimulated human microvascular endothelial cells, as well as mouse and rat RET16 orthologs thereof. Also described are the RET16 polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Methods for screening for modulators, particularly inhibitors, of the human RET16 protein, and use of the RET16 polynucleotide and polypeptide for therapeutics and diagnostics are described.

    摘要翻译： 本发明描述了一种新发现的多核苷酸，其编码参与由TNF-α刺激的人微血管内皮细胞以及小鼠和大鼠RET16直系同源物克隆，分离和鉴定的细胞信号级联的称为RET16的蛋白质。 还描述了与本发明的多核苷酸和/或多肽相关的RET16多肽序列，表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。 描述了用于筛选人RET16蛋白的调节剂，特别是抑制剂的方法，以及RET16多核苷酸和多肽用于治疗和诊断的用途。