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7 条记录 (耗时 0.018 秒)

    9-Amino-3,4-dihydroacridines and related compounds useful for enhancing memory
    1.
    发明授权
    9-Amino-3,4-dihydroacridines and related compounds useful for enhancing memory 失效
    9-氨基-3,4-二氢吖啶和有助于增强记忆的相关化合物

    公开(公告)号：US4839364A

    公开(公告)日：1989-06-13

    申请号：US7885

    申请日：1987-01-28

    申请人： Gregory M. Shutske ,  Frank A. Pierrat

    发明人： Gregory M. Shutske ,  Frank A. Pierrat

    IPC分类号： C07C255/42 ,  A61K31/435 ,  A61K31/47 ,  C07C20060101 ,  C07C67/00 ,  C07C253/00 ,  C07C255/58 ,  C07C255/59 ,  C07C255/60 ,  C07D219/08 ,  C07D219/10 ,  C07D219/12 ,  C07D221/16 ,  C07D409/12

    CPC分类号： C07D409/12 ,  C07C255/00 ,  C07D219/10 ,  C07D219/12 ,  C07D221/16

    摘要： There are disclosed compounds having the formula ##STR1## wherein n is 1, 2 or 3; X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, NHCOR.sub.2 where R.sub.2 is loweralkyl, or NR.sub.3 R.sub.4 where R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl; R is hydrogen or loweralkyl; R.sub.1 is hydrogen, loweralkyl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, furylloweralkyl, thienylloweralkyl, oxygen-bridged arylloweralkyl, oxygen-bridged diarylloweralkyl, oxygen-bridged furylloweralkyl or oxygen-bridged thienylloweralkyl; Y is C.dbd.O or CR.sub.5 OH where R.sub.5 is hydrogen or loweralkyl; Z is CH.sub.2 or C.dbd.CR.sub.6 R.sub.7 where R.sub.6 and R.sub.7 are independently hydrogen or loweralkyl; or Y and Z taken together is CR.sub.5 .dbd.Ch where CR.sub.5 and CH correspond to Y and Z respectively; an optical antipode thereof, or a pharmaceutically acceptable acid addition salt thereof, which are useful for enhancing memory, methods for synthesizing them, and pharmaceutical compositions comprising an effective memory enhancing amount of such a compound.

    摘要翻译： 公开了具有式“IMAGE”的化合物，其中n为1,2或3; X是氢，低级烷基，低级烷氧基，卤素，羟基，硝基，三氟甲基，NHCOR 2，其中R2是低级烷基，或NR3R4，其中R3和R4独立地是氢或低级烷基; R是氢或低级烷基; R 1是氢，低级烷基，二低级烷基氨基低级烷基，芳基低级烷基，二芳基低级烷基，呋喃基烷基，噻吩基低级烷基，氧桥连的芳基低级烷基，氧桥连的二芳基低级烷基，氧桥连的呋喃基低级烷基或氧桥连的噻吩基低级烷基。 Y是C = O或CR5OH，其中R5是氢或低级烷基; Z是CH 2或C = CR 6 R 7，其中R 6和R 7独立地是氢或低级烷基; 或Y和Z一起为CR5 = Ch，其中CR5和CH分别对应于Y和Z; 可用于增强记忆力的光学对映体或其药学上可接受的酸加成盐，以及合成它们的方法和包含有效记忆增加量的这种化合物的药物组合物。

    Method of preparing 9-amino-1,2,3,4,-tetrahydroacridin-1-ones and related compounds
    2.
    发明授权
    Method of preparing 9-amino-1,2,3,4,-tetrahydroacridin-1-ones and related compounds 失效
    制备9-氨基-1,2,3,4-四氢吖啶-1-酮和相关化合物的方法

    公开(公告)号：US4835275A

    公开(公告)日：1989-05-30

    申请号：US125109

    申请日：1987-11-25

    申请人： Gregory M. Shutske ,  Frank A. Pierrat

    发明人： Gregory M. Shutske ,  Frank A. Pierrat

    IPC分类号： C07D219/10 ,  C07D219/12 ,  C07D221/16 ,  C07D409/12

    CPC分类号： C07D409/12 ,  C07C255/00 ,  C07D219/10 ,  C07D219/12 ,  C07D221/16

    摘要： There are disclosed compounds having the formula ##STR1## wherein n is 1, 2 or 3; X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, NHCOR.sub.2 where R.sub.2 is loweralkyl, or NR.sub.3 R.sub.4 where R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl; R is hydrogen or loweralkyl; R.sub.1 is hydrogen, loweralkyl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, furylloweralkyl, thienylloweralkyl, oxygen-bridged arylloweralkyl, oxygen-bridged diarylloweralkyl, oxygen-bridged furylloweralkyl or oxygen-bridged thienylloweralkyl; Y is C.dbd.O or CR.sub.5 OH where R.sub.5 is hydrogen or loweralkyl; Z is CH.sub.2 or C.dbd.CR.sub.6 R.sub.7 where R.sub.6 and R.sub.7 are independently hydrogen or loweralkyl; or Y and Z taken together is CR.sub.5 .dbd.CH where CR.sub.5 and CH correspond to Y and Z respectively; an optical antipode thereof, or a pharmaceutically acceptable acid addition salt thereof, which are useful for enhancing memory, methods for synthesizing them, and pharmaceutical compositions comprising an effective memory enhancing amount of such a compound.

    摘要翻译： 公开了具有式“IMAGE”的化合物，其中n为1,2或3; X是氢，低级烷基，低级烷氧基，卤素，羟基，硝基，三氟甲基，NHCOR 2，其中R2是低级烷基，或NR3R4，其中R3和R4独立地是氢或低级烷基; R是氢或低级烷基; R 1是氢，低级烷基，二低级烷基氨基低级烷基，芳基低级烷基，二芳基低级烷基，呋喃基烷基，噻吩基低级烷基，氧桥连的芳基低级烷基，氧桥连的二芳基低级烷基，氧桥连的呋喃基低级烷基或氧桥连的噻吩基低级烷基。 Y是C = O或CR5OH，其中R5是氢或低级烷基; Z是CH 2或C = CR 6 R 7，其中R 6和R 7独立地是氢或低级烷基; 或Y和Z一起为CR5 = CH，其中CR5和CH分别对应于Y和Z; 可用于增强记忆力的光学对映体或其药学上可接受的酸加成盐，以及合成它们的方法和包含有效记忆增加量的这种化合物的药物组合物。

    9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
    3.
    发明授权
    9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds 失效
    9-氨基-1,2,3,4-四氢吖啶-1-醇及相关化合物

    公开(公告)号：US4631286A

    公开(公告)日：1986-12-23

    申请号：US664731

    申请日：1984-10-25

    申请人： Gregory M. Shutske ,  Frank A. Pierrat

    发明人： Gregory M. Shutske ,  Frank A. Pierrat

    IPC分类号： A61K31/435 ,  A61K31/47 ,  A61K31/473 ,  A61P25/02 ,  A61P43/00 ,  C07C67/00 ,  C07C253/00 ,  C07C255/58 ,  C07D219/10 ,  C07D219/12 ,  C07D221/16 ,  C07D333/00 ,  C07D405/12 ,  C07D409/12

    CPC分类号： C07D409/12 ,  C07C255/00 ,  C07D219/10 ,  C07D219/12 ,  C07D221/16

    摘要： There are disclosed compounds having the formula ##STR1## wherein X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, NHCOR.sub.2 wherein R.sub.2 is loweralkyl, or a group of the formula NR.sub.3 R.sub.4 wherein R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl; R and R.sub.1 are independently hydrogen, loweralkyl, phenylloweralkyl, phenylloweralkyl in which the phenyl group is substituted by one or more loweralkyl, loweralkoxy, halogen, hydroxy or trifluoromethyl, diphenylloweralkyl or diphenylloweralkyl in which one or both phenyl groups are substituted by one or more loweralkyl, loweralkoxy, halogen, hydroxy or trifluoromethyl; Y is C.dbd.O or CR.sub.5 OH wherein R.sub.5 is hydrogen or loweralkyl; Z is CH.sub.2 or C.dbd.CR.sub.6 R.sub.7 wherein R.sub.6 and R.sub.7 are independently hydrogen or loweralkyl; or Y and Z taken together is CR.sub.5 .dbd.CH wherein CR.sub.5 and CH correspond to Y and Z respectively; an optical antipode thereof, or a pharmaceutically acceptable acid addition salt thereof, which are useful for enhancing memory, methods for synthesizing them, and pharmaceutical compositions comprising an effective memory enhancing amount of such a compound.

    摘要翻译： 公开了具有式“IMAGE”的化合物，其中X是氢，低级烷基，低级烷氧基，卤素，羟基，硝基，NHCOR 2，其中R2是低级烷基，或式NR3R4基团，其中R3和R4独立地是氢或低级烷基; R和R 1独立地是氢，低级烷基，苯基低级烷基，苯基低级烷基，其中苯基被一个或多个低级烷基，低级烷氧基，卤素，羟基或三氟甲基取代，二苯基低级烷基或二苯基低级烷基，其中一个或两个苯基被一个或多个低级烷基 ，低级烷氧基，卤素，羟基或三氟甲基; Y是C = O或CR5OH，其中R5是氢或低级烷基; Z是CH 2或C = CR 6 R 7，其中R 6和R 7独立地是氢或低级烷基; 或Y和Z一起为CR5 = CH，其中CR5和CH分别对应于Y和Z; 可用于增强记忆力的光学对映体或其药学上可接受的酸加成盐，以及合成它们的方法和包含有效记忆增加量的这种化合物的药物组合物。

    9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
    4.
    发明授权
    9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds 失效
    9-氨基-1,2,3,4-四氢吖啶-1-醇及相关化合物

    公开(公告)号：US4754050A

    公开(公告)日：1988-06-28

    申请号：US125526

    申请日：1987-11-25

    申请人： Gregory M. Shutske ,  Frank A. Pierrat

    发明人： Gregory M. Shutske ,  Frank A. Pierrat

    IPC分类号： C07D219/10 ,  C07D219/12 ,  C07D221/16 ,  C07D409/12 ,  C07C121/52

    CPC分类号： C07D409/12 ,  C07C255/00 ,  C07D219/10 ,  C07D219/12 ,  C07D221/16

    摘要： There are disclosed compounds having the formula ##STR1## wherein n is 1, 2 or 3; X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, NHCOR.sub.2 where R.sub.2 is loweralkyl, or NR.sub.3 R.sub.4 where R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl; R is hydrogen or loweralkyl; R.sub.1 is hydrogen, loweralkyl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, furylloweralkyl, thienylloweralkyl, oxygen-bridged arylloweralkyl, oxygen-bridged diarylloweralkyl, oxygen-bridged furylloweralkyl or oxygen-bridged thienylloweralkyl; Y is C.dbd.O or CR.sub.5 OH where R.sub.5 is hydrogen or loweralkyl; Z is CH.sub.2 or C.dbd.CR.sub.6 R.sub.7 where R.sub.6 and R.sub.7 are independently hydrogen or loweralkyl; or Y and Z taken together is CR.sub.5 .dbd.CH where CR.sub.5 and CH correspond to Y and Z respectively; an optical antipode thereof, or a pharmaceutically acceptable acid addition salt thereof, which are useful for enhancing memory, methods for synthesizing them, and pharmaceutical compositions comprising an effective memory enhancing amount of such a compound.

    摘要翻译： 公开了具有式“IMAGE”的化合物，其中n为1,2或3; X是氢，低级烷基，低级烷氧基，卤素，羟基，硝基，三氟甲基，NHCOR 2，其中R2是低级烷基，或NR3R4，其中R3和R4独立地是氢或低级烷基; R是氢或低级烷基; R 1是氢，低级烷基，二低级烷基氨基低级烷基，芳基低级烷基，二芳基低级烷基，呋喃基烷基，噻吩基低级烷基，氧桥连的芳基低级烷基，氧桥连的二芳基低级烷基，氧桥连的呋喃基低级烷基或氧桥连的噻吩基低级烷基。 Y是C = O或CR5OH，其中R5是氢或低级烷基; Z是CH 2或C = CR 6 R 7，其中R 6和R 7独立地是氢或低级烷基; 或Y和Z一起为CR5 = CH，其中CR5和CH分别对应于Y和Z; 可用于增强记忆力的光学对映体或其药学上可接受的酸加成盐，以及合成它们的方法和包含有效记忆增加量的这种化合物的药物组合物。

    9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
    5.
    发明授权
    9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds 失效

    公开(公告)号：US4695573A

    公开(公告)日：1987-09-22

    申请号：US781155

    申请日：1985-10-01

    申请人： Gregory M. Shutske ,  Frank A. Pierrat

    发明人： Gregory M. Shutske ,  Frank A. Pierrat

    IPC分类号： A61K31/47 ,  C07D219/10 ,  C07D219/12 ,  C07D221/16 ,  C07D409/12

    CPC分类号： C07D409/12 ,  C07C255/00 ,  C07D219/10 ,  C07D219/12 ,  C07D221/16

    摘要： There are disclosed compounds having the formula ##STR1## wherein n is 1, 2 or 3; X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, NHCOR.sub.2 where R.sub.2 is loweralkyl, or NR.sub.3 R.sub.4 where R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl; R is hydrogen or loweralkyl; R.sub.1 is hydrogen, loweralkyl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, furylloweralkyl, thienylloweralkyl, oxygen-bridged arylloweralkyl, oxygen-bridged diarylloweralkyl, oxygen-bridged furylloweralkyl or oxygen-bridged thienylloweralkyl; Y is C.dbd.O or CR.sub.5 OH where R.sub.5 is hydrogen or loweralkyl; Z is CH.sub.2 or C.dbd.CR.sub.6 R.sub.7 where R.sub.6 and R.sub.7 are independently hydrogen or loweralkyl; or Y and Z taken together is CR.sub.5 .dbd.CH where CR.sub.5 and CH correspond to Y and Z respectively; an optical antipode thereof, or a pharmaceutically acceptable acid addition salt thereof, which are useful for enhancing memory, methods for synthesizing them, and pharmaceutical compositions comprising an effective memory enhancing amount of such a compound.