公开(公告)号：US3832387A

公开(公告)日：1974-08-27

申请号：US23542172

申请日：1972-03-16

Applicant: HOFFMANN LA ROCHE

Inventor： KRUBINER A ,  OLIVETO E

IPC: C07C205/53 ,  C07C79/46

CPC classification number: C07C205/53 ,  C07C201/10

Abstract: Alpha -nitro-cinnamic acid derivatives which are useful in preparing phenylalanines, and a process for obtaining the derivatives by treating the corresponding cinnamic acid esters with nitric oxide or nitrogen dioxide.

Abstract translation: 可用于制备苯丙氨酸的α-硝基肉桂酸衍生物，以及通过用一氧化氮或二氧化氮处理相应的肉桂酸酯来获得衍生物的方法。

公开(公告)号：US3716530A

公开(公告)日：1973-02-13

申请号：US3716530D

申请日：1971-08-10

Applicant: HOFFMANN LA ROCHE

Inventor： KRUBINER A ,  OLIVETO E

IPC: C07J5/00 ,  C07J7/00 ,  C07J13/00 ,  C07C173/00 ,  C07C169/08

CPC classification number: C07J13/007 ,  C07J5/0053 ,  C07J7/0045

Abstract: A process for converting 17 Alpha -vinyl-17 Beta -hydroxy steroids to 17-(2-haloethylidene)-steroids, known intermediates for antifungal and progestational agents, by treating the 17 Alpha -vinyl-17 Beta -hydroxy steroids with vanadium tetrahalide.

Abstract translation: 通过用四卤化钒处理17α-乙烯基-17β-羟基类固醇，将17α-乙烯基-17β-羟基类固醇转化为17-（2-卤代亚乙基） - 类固醇，已知的抗真菌和促孕剂中间体的方法。

公开(公告)号：US3825569A

公开(公告)日：1974-07-23

申请号：US18011571

申请日：1971-09-13

Applicant: HOFFMANN LA ROCHE

Inventor： HAJOS Z ,  OLIVETO E

IPC: C07C43/12 ,  C07C45/00 ,  C07D309/12 ,  C07D317/16 ,  C07D317/26 ,  C07D13/04

CPC classification number: C07C45/69 ,  C07C43/12 ,  C07C45/00 ,  C07C45/64 ,  C07C45/71 ,  C07C2603/16 ,  C07C2603/26 ,  C07D309/12 ,  C07D317/16 ,  C07D317/26 ,  C07C49/16 ,  C07C49/753 ,  C07C49/513 ,  C07C49/633

Abstract: METHODS FOR THE PREPARATION OF 2,3,3A,4,5,7,8,9,9AB,9BADECAHYDRO - 3AB-PRIMARY LOWER ALKYL-7-OXO-1H-BENZ(E) INDENES AND 4,4AB,4BA,5,6,7,8,8A,9,10-DECAHYDRO-8AB-PRIMARY LOWER ALKYL - 3H-PHENANTHREN-2-ONES BY CYCLIZING COMPOUNDS OF THE FORMULA
WHERE R1 IS HYDROGEN OR LOWER ALKYL; Z'' IS CARBONYL OR CH(OR2''); R2'' IS HYDROGEN, LOWER AKYL, LOWER ALKANOYL, BENZOYL, NITROBENZOYL, CARBOXY-LOWER ALKANOYL, CARBOXYBENZOYL, TRIFLUOROACETYL OR CAMPHORSULFONYL; T'' IS -C(X'')=CH-, -C(OR3)=CH- OR -Q''-CH2-; R3 IS LOWER ALKYL; X'' IS BROMINE, CHLORINE OR IODINE; Q'' IS CARBONYL, LOWER ALKYLENE DIOXY-METHYLENE, DI-(LOWER ALKOXY)-METHYLENE OR HYDROXY-METHYLENE, R4 IS LOWER PRIMARY ALKYL AND M IS AN INTEGER HAVING A VALUE OF 1 OR 2. THE COMPOUNDS OF THIS SERIES ARE USEFUL AS INTERMEDIATES IN THE SYNTHESIS OF KNOWN STEROIDS WHICH ARE PHARMACOLOGICALLY ACTIVE AS FERTILITY CONTROL AGENTS.

CH3)-)

R1-CH2-T''-CH2-CH(-CO-H)-CH