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公开(公告)号：US5846534A
公开(公告)日：1998-12-08
申请号：US235705
申请日：1994-04-29
IPC分类号： A61K38/00 , C07K16/28 , C07K16/46 , A61K39/395 , C07K16/30
CPC分类号： C07K16/465 , C07K16/2893 , A61K38/00 , C07K2317/24 , C07K2317/734 , C07K2319/00 , C07K2319/02
摘要： An antibody is produced, which will bind effectively with the antigen Campath-1, and which has at least one complementarity determining region of rat origin, as identified in FIG. 2, which may be combined with a range of different foreign variable domain framework regions as desired, including framework regions of human origin.
摘要翻译： 产生抗体，其与抗原Campath-1有效结合，并且其具有至少一个大鼠来源的互补决定区，如图1所示。 2，其可以与期望的一系列不同的外部可变结构域框架区域结合，包括人源的框架区域。
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公开(公告)号：US06569430B1
公开(公告)日：2003-05-27
申请号：US08407620
申请日：1995-03-21
IPC分类号： A61K39395
CPC分类号： C07K16/465 , A61K38/00 , C07K16/2893 , C07K2317/24 , C07K2317/734 , C07K2319/00 , C07K2319/02
摘要： An antibody is produced, which will bind effectively with the antigen Campath-1, and which has at least one complementarity determining region of rat origin, as identified in FIG. 2, which may be combined with a range of different foreign variable domain framework regions as desired, including framework regions of human origin.
摘要翻译： 产生抗体，其与抗原Campath-1有效结合，并且其具有至少一个大鼠来源的互补决定区，如图1所示。 2，其可以与期望的一系列不同的外部可变结构域框架区域结合，包括人源的框架区域。
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公开(公告)号：US06969586B1
公开(公告)日：2005-11-29
申请号：US09726649
申请日：2000-11-28
CPC分类号： C07K16/005 , C07K16/00 , C07K16/44 , C07K2317/21 , C07K2317/55 , C07K2317/569 , C07K2317/622 , C12Q1/6876
摘要： The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
摘要翻译： 本发明涉及从免疫基因库中分离编码具有结合预选配体的能力的受体的基因的方法。 还考虑了通过该方法分离的基因产生的受体，特别是催化受体。
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公开(公告)号：US06291161B1
公开(公告)日：2001-09-18
申请号：US07941762
申请日：1992-09-04
IPC分类号： C12Q168
CPC分类号： C07K16/468 , A61K38/00 , C07K16/00 , C07K2317/56
摘要： The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
摘要翻译： 本发明涉及从免疫基因库中分离编码具有结合预选配体的能力的受体的基因的方法。 还考虑了通过该方法分离的基因产生的受体，特别是催化受体。
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公开(公告)号：US07189841B2
公开(公告)日：2007-03-13
申请号：US10910463
申请日：2004-08-02
IPC分类号： C07H21/04
CPC分类号： C07K16/005 , C07K16/00 , C07K16/44 , C07K2317/21 , C07K2317/55 , C07K2317/569 , C07K2317/622 , C12Q1/6876
摘要： The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
摘要翻译： 本发明涉及从免疫基因库中分离编码具有结合预选配体的能力的受体的基因的方法。 还考虑了通过该方法分离的基因产生的受体，特别是催化受体。
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公开(公告)号：US07858359B2
公开(公告)日：2010-12-28
申请号：US11558384
申请日：2006-11-09
IPC分类号： C12N1/21
CPC分类号： C07K16/00 , A61K38/00 , C07K16/468 , C07K2317/56
摘要： The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
摘要翻译： 本发明涉及从免疫基因库中分离编码具有结合预选配体的能力的受体的基因的方法。 还考虑了通过该方法分离的基因产生的受体，特别是催化受体。
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公开(公告)号：US06291159B1
公开(公告)日：2001-09-18
申请号：US07933959
申请日：1992-08-21
IPC分类号： C12Q168
CPC分类号： C07K16/005 , A61K38/00 , C07K16/00 , C07K16/44 , C07K16/468 , C07K2317/55 , C07K2317/56
摘要： The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
摘要翻译： 本发明涉及从免疫基因库中分离编码具有结合预选配体的能力的受体的基因的方法。 还考虑了通过该方法分离的基因产生的受体，特别是催化受体。
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公开(公告)号：US06291158B1
公开(公告)日：2001-09-18
申请号：US07933958
申请日：1992-08-21
IPC分类号： C12Q168
CPC分类号： C07K16/00 , A61K38/00 , C07K16/468 , C07K2317/56
摘要： The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
摘要翻译： 本发明涉及从免疫基因库中分离编码具有结合预选配体的能力的受体的基因的方法。 还考虑了通过该方法分离的基因产生的受体，特别是催化受体。
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公开(公告)号：US08338107B2
公开(公告)日：2012-12-25
申请号：US11560769
申请日：2006-11-16
IPC分类号： C12Q1/68
CPC分类号： C07K16/005 , A61K38/00 , C07K16/00 , C07K16/44 , C07K16/468 , C07K2317/55 , C07K2317/56
摘要： The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
摘要翻译： 本发明涉及从免疫基因库中分离编码具有结合预选配体的能力的受体的基因的方法。 还考虑了通过该方法分离的基因产生的受体，特别是催化受体。
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10.发明申请Process for Recovering Polypeptides that Unfold Reversibly from a Polypeptide Repertoire 审中-公开从多肽汇编可逆地展开多肽的方法公开(公告)号：US20090005257A1
公开(公告)日：2009-01-01
申请号：US10556360
申请日：2004-05-14
CPC分类号： C40B40/02 , C07K1/1136 , C07K16/00 , C07K2317/567 , C07K2317/569 , C12N15/1037
摘要： The invention relates to polypeptides that unfold reversibly (e.g., unfolds when heated and refolds when cooled), to repertoires containing polypeptides that unfold reversibly and to libraries that contain polypeptides that unfold reversibly or nucleic acids that encode polypeptides that unfold reversibly. The invention further relates to processes for producing a library enriched in polypeptides that unfold reversibly or nucleic acids encoding polypeptides that unfold reversibly, processes for selecting and/or isolating polypeptides that unfold reversibly, and to methods for producing a polypeptide that unfolds reversibly.
摘要翻译： 本发明涉及可逆地展开的多肽（例如，当被冷却时被加热和重新折叠时展开），以及含有可逆展开的多肽的库和包含可逆展开的多肽的文库或编码可逆展开的多肽的核酸。 本发明还涉及产生富含可逆地展开的多肽的文库或编码可逆展开的多肽的核酸的方法，用于选择和/或分离可逆展开的多肽的方法，以及用于产生可逆展开的多肽的方法。
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