公开(公告)号：US20150293104A1

公开(公告)日：2015-10-15

申请号：US14413846

申请日：2012-07-12

申请人： Hirofumi Nozaki ,  Takashi Ohkura ,  Atsushi Kuno ,  Maki Sogabe ,  Tomomi Kubota ,  Hiroyuki Kaji ,  Akira Togayachi ,  Yuzuru Ikehara ,  Hisashi Narimatsu ,  Hayao Nakanishi ,  Toru Nakanishi

发明人： Hirofumi Nozaki ,  Takashi Ohkura ,  Atsushi Kuno ,  Maki Sogabe ,  Tomomi Kubota ,  Hiroyuki Kaji ,  Akira Togayachi ,  Yuzuru Ikehara ,  Hisashi Narimatsu ,  Hayao Nakanishi ,  Toru Nakanishi

IPC分类号： G01N33/574

CPC分类号： G01N33/57449 ,  C07K14/47 ,  G01N33/6842 ,  G01N2333/78 ,  G01N2333/8121 ,  G01N2333/902 ,  G01N2333/90287 ,  G01N2333/96458

摘要： An object of the present invention is to develop and provide an epithelial ovarian cancer diagnosis marker with which epithelial ovarian cancer can be detected inexpensively, conveniently, and low invasively with high accuracy, and a method for determining the presence or absence of epithelial ovarian cancer using the marker. The present invention provides a glycoprotein having a glycan-linked asparagine residue at a particular site of the glycoprotein secreted from an epithelial ovarian cancer cell, or a fragment thereof having the glycan as an epithelial ovarian cancer diagnosis marker. The present invention also provides a method for determining the presence or absence of epithelial ovarian cancer using the glycoprotein.

摘要翻译： 本发明的目的是开发和提供一种上皮性卵巢癌诊断标记，其可以廉价地，方便地和低侵入性高精度地检测上皮性卵巢癌，以及使用以下方法确定上皮性卵巢癌的存在或不存在的方法： 标记。 本发明提供一种在从上皮性卵巢癌细胞分泌的糖蛋白的特定部位或其具有聚糖作为上皮性卵巢癌诊断标记的片段的具有聚糖连接的天冬酰胺残基的糖蛋白。 本发明还提供了使用糖蛋白来确定上皮性卵巢癌的存在或不存在的方法。

公开(公告)号：US10247733B2

公开(公告)日：2019-04-02

申请号：US14234871

申请日：2012-07-26

申请人： Maki Sogabe ,  Tomomi Kubota ,  Akira Togayachi ,  Yuzuru Ikehara ,  Hisashi Narimatsu ,  Hiromichi Sawaki ,  Hayao Nakanishi ,  Toru Nakanishi

发明人： Maki Sogabe ,  Tomomi Kubota ,  Akira Togayachi ,  Yuzuru Ikehara ,  Hisashi Narimatsu ,  Hiromichi Sawaki ,  Hayao Nakanishi ,  Toru Nakanishi

IPC分类号： G01N33/50 ,  G01N33/574 ,  C07K16/40

摘要： It is intended to find a highly specific epithelial ovarian cancer marker and to provide an antibody capable of specifically recognizing and detecting the marker or a fragment of the antibody. The present invention provides an anti-β1,6-N-acetylglucosaminyltransferase 5B antibody for diagnosis of epithelial ovarian cancer, i.e., an antibody for detection of a glycosyltransferase β1,6-N-acetylglucosaminyltransferase 5B as an epithelial ovarian cancer marker. The antibody recognizes, as an epitope, a part of a polypeptide of the enzyme consisting of the amino acid sequence represented by SEQ ID NO: 1.

公开(公告)号：US20140295455A1

公开(公告)日：2014-10-02

申请号：US14234783

申请日：2012-07-26

申请人： Maki Sogabe ,  Tomomi Kubota ,  Akira Togayachi ,  Yuzuru Ikehara ,  Hisashi Narimatsu ,  Hiromichi Sawaki ,  Hayao Nakanishi ,  Toru Nakanishi

发明人： Maki Sogabe ,  Tomomi Kubota ,  Akira Togayachi ,  Yuzuru Ikehara ,  Hisashi Narimatsu ,  Hiromichi Sawaki ,  Hayao Nakanishi ,  Toru Nakanishi

IPC分类号： G01N33/574 ,  C07K16/40

CPC分类号： G01N33/57449 ,  C07K16/3069 ,  C07K16/40 ,  C12N5/163

摘要： The present invention provides an antibody capable of specifically recognizing and detecting the highly specific cancer marker with respect to the epithelial ovarian cancer, or a fragment of the antibody. The present invention provides an anti-β1,3-N-acetylglucosaminyltransferase 3 antibody for diagnosis of epithelial ovarian cancer, i.e., an antibody for detection of a glycosyltransferase β1,3-N-acetylglucosaminyltransferase 3 as an epithelial ovarian cancer marker. The antibody recognizes, as an epitope, a part of a polypeptide of the enzyme consisting of the amino acid sequence represented by SEQ ID NO: 1.

摘要翻译： 本发明提供能够特异性识别和检测关于上皮性卵巢癌或抗体片段的高度特异性癌症标志物的抗体。 本发明提供了用于诊断上皮性卵巢癌的抗 - 1,3-N-乙酰氨基葡糖转移酶3抗体，即用于检测糖基转移酶的抗体和作为上皮性卵巢癌标志物的1,3-N-乙酰氨基葡糖转移酶3 。 抗体识别由SEQ ID NO：1表示的氨基酸序列组成的酶的多肽的一部分作为表位。

公开(公告)号：US09816996B2

公开(公告)日：2017-11-14

申请号：US14234783

申请日：2012-07-26

申请人： Maki Sogabe ,  Tomomi Kubota ,  Akira Togayachi ,  Yuzuru Ikehara ,  Hisashi Narimatsu ,  Hiromichi Sawaki ,  Hayao Nakanishi ,  Toru Nakanishi

发明人： Maki Sogabe ,  Tomomi Kubota ,  Akira Togayachi ,  Yuzuru Ikehara ,  Hisashi Narimatsu ,  Hiromichi Sawaki ,  Hayao Nakanishi ,  Toru Nakanishi

IPC分类号： G01N33/574 ,  C12N5/16 ,  C07K16/30 ,  C07K16/40

CPC分类号： G01N33/57449 ,  C07K16/3069 ,  C07K16/40 ,  C12N5/163

摘要： The present invention provides an antibody capable of specifically recognizing and detecting the highly specific cancer marker with respect to the epithelial ovarian cancer, or a fragment of the antibody. The present invention provides an anti-β1,3-N-acetylglucosaminyltransferase 3 antibody for diagnosis of epithelial ovarian cancer, i.e., an antibody for detection of a glycosyltransferase β1,3-N-acetylglucosaminyltransferase 3 as an epithelial ovarian cancer marker. The antibody recognizes, as an epitope, a part of a polypeptide of the enzyme consisting of the amino acid sequence represented by SEQ ID NO: 1.

公开(公告)号：US20140242607A1

公开(公告)日：2014-08-28

申请号：US14234871

申请日：2012-07-26

申请人： Maki Sogabe ,  Tomomi Kubota ,  Akira Togayachi ,  Yuzuru Ikehara ,  Hisashi Narimatsu ,  Hiromichi Sawaki ,  Hayao Nakanishi ,  Toru Nakanishi

发明人： Maki Sogabe ,  Tomomi Kubota ,  Akira Togayachi ,  Yuzuru Ikehara ,  Hisashi Narimatsu ,  Hiromichi Sawaki ,  Hayao Nakanishi ,  Toru Nakanishi

IPC分类号： G01N33/574 ,  C07K16/40

CPC分类号： G01N33/57449 ,  C07K16/40 ,  C07K2317/33 ,  C07K2317/34

摘要： It is intended to find a highly specific epithelial ovarian cancer marker and to provide an antibody capable of specifically recognizing and detecting the marker or a fragment of the antibody. The present invention provides an anti-β1,6-N-acetylglucosaminyltransferase 5B antibody for diagnosis of epithelial ovarian cancer, i.e., an antibody for detection of a glycosyltransferase β1,6-N-acetylglucosaminyltransferase 5B as an epithelial ovarian cancer marker. The antibody recognizes, as an epitope, a part of a polypeptide of the enzyme consisting of the amino acid sequence represented by SEQ ID NO: 1.

摘要翻译： 旨在找到高度特异性的上皮性卵巢癌标记物，并提供能够特异性识别和检测抗体的标记或片段的抗体。 本发明提供了一种用于诊断上皮性卵巢癌的抗 - 1gr-1-1-Gly-Gly-Gly-glucogaminamintransferase 5B抗体，即用于检测作为上皮性卵巢癌标志物的糖基转移酶和1,6-N-乙酰葡糖胺基转移酶5B的抗体 。 抗体识别由SEQ ID NO：1表示的氨基酸序列组成的酶的多肽的一部分作为表位。