公开(公告)号：US20230203043A1

公开(公告)日：2023-06-29

申请号：US17976651

申请日：2022-10-28

申请人： Hoffmann-La Roche Inc.

发明人： Jean-Baptiste BLANC ,  Christian LERNER ,  Matthias NETTEKOVEN ,  Philippe PFLIEGER ,  Bernd PUELLMANN ,  Sébastien SCHMITT ,  Theodor STOLL ,  Song YANG ,  Chengang ZHOU

IPC分类号： C07D487/04 ,  C07D519/00

CPC分类号： C07D487/04 ,  C07D519/00

摘要： The invention provides novel imidazopyrazine derivatives having the general formula (I), or pharmaceutically acceptable salts thereof, wherein X and R3 to R9 are as described herein:




Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20230013602A1

公开(公告)日：2023-01-19

申请号：US17349888

申请日：2021-06-16

申请人： Hoffmann-La Roche Inc.

发明人： Jean-Baptiste BLANC ,  Nawaz KHAN ,  Christian KRAMER ,  Christian LERNER ,  Philippe PFLIEGER ,  Theodor STOLL ,  Song YANG

IPC分类号： C07D487/04 ,  A61P31/04 ,  B01J31/12

摘要： Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R14 are as described herein and pharmaceutically acceptable salts thereof.
Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20230203047A1

公开(公告)日：2023-06-29

申请号：US18070648

申请日：2022-11-29

申请人： Hoffmann-La Roche Inc.

发明人： Christian LERNER ,  Yongqiang LIU ,  Song YANG ,  Chengang ZHOU

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： The invention provides novel imidazopyrazine derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X1 to X4, R1 to R5, R8 to R10, A, and L1 are as described herein:




Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20230141600A1

公开(公告)日：2023-05-11

申请号：US18076274

申请日：2022-12-06

申请人： Hoffmann-La Roche Inc.

发明人： Zhanling CHENG ,  Christian KRAMER ,  Christian LERNER ,  Yongqiang LIU ,  Matthias NETTEKOVEN ,  Philippe PFLIEGER ,  Sébastien SCHMITT ,  Theodor STOLL ,  Jianhua WANG ,  Yongguang WANG ,  Song YANG ,  Chengang ZHOU

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61P31/04 ,  A61K9/20 ,  A61K9/48 ,  A61K9/08 ,  A61K47/12 ,  A61K47/40

CPC分类号： C07D487/04 ,  C07D519/00 ,  A61P31/04 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2009 ,  A61K9/4866 ,  A61K9/4858 ,  A61K9/485 ,  A61K9/08 ,  A61K47/12 ,  A61K47/40

摘要： The invention provides novel imidazopyrazine derivatives having the general formula (I), wherein Rx and R3 to R5 are as described herein:




or pharmaceutically acceptable salts thereof.
Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20230017532A1

公开(公告)日：2023-01-19

申请号：US17349862

申请日：2021-06-16

申请人： Hoffmann-La Roche Inc.

发明人： Zhanling CHENG ,  Nawaz KHAN ,  Christian KRAMER ,  Christian LERNER ,  Matthias NETTEKOVEN ,  Philippe PFLIEGER ,  Bernd PUELLMANN ,  Sebastien SCHMITT ,  Theodor STOLL ,  Jianhua WANG ,  Song YANG

IPC分类号： C07D487/04 ,  C07D519/00

摘要： Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof.
Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and related diseases.

公开(公告)号：US20230011869A1

公开(公告)日：2023-01-12

申请号：US17349800

申请日：2021-06-16

申请人： Hoffmann-La Roche Inc.

发明人： Zhanling CHENG ,  Nawaz KHAN ,  Christian KRAMER ,  Christian LERNER ,  Philippe PFLIEGER ,  Theodor STOLL ,  Jianhua WANG ,  Min WANG ,  Yongguang WANG ,  Song YANG

IPC分类号： C07D487/04 ,  C07D519/00

摘要： Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20230257354A1

公开(公告)日：2023-08-17

申请号：US18117966

申请日：2023-03-06

申请人： Hoffmann-La Roche Inc.

发明人： Zhanling CHENG ,  Christian LERNER ,  Yongqiang LIU ,  Matthias NETTEKOVEN ,  Philippe PFLIEGER ,  Bernd PUELLMANN ,  Jianhua WANG ,  Min WANG ,  Yongguang WANG ,  Song YANG ,  Chengang ZHOU

IPC分类号： C07D233/90 ,  C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  A61P31/04

CPC分类号： C07D233/90 ,  C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  A61P31/04

摘要： The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R9 and p are as described herein:




Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20230234939A1

公开(公告)日：2023-07-27

申请号：US18114959

申请日：2023-02-27

申请人： Hoffmann-La Roche Inc.

发明人： Sandra Marie Joseph GRALL-ULSEMER ,  Wolfgang GUBA ,  Christian LERNER ,  Mingming LI ,  Yongqiang LIU ,  Markus RUDOLPH ,  Sébastien SCHMITT ,  Lorenz URNER ,  Yongguang WANG ,  Min WANG ,  Jianhua WANG ,  Song YANG ,  Chengang ZHOU ,  Patrizio MATTEI

IPC分类号： C07D401/14 ,  C07D403/14 ,  A61P31/04

CPC分类号： C07D401/14 ,  C07D403/14 ,  A61P31/04

摘要： The invention provides novel imidazole pyrazole derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein A and R1-R7 are as described herein:




Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20230141403A1

公开(公告)日：2023-05-11

申请号：US18076383

申请日：2022-12-06

申请人： Hoffmann-La Roche Inc.

发明人： Zhanling CHENG ,  Xingchun HAN ,  Christian KRAMER ,  Holger KUEHNE ,  Christian LERNER ,  Mingming LI ,  Matthias NETTEKOVEN ,  Theodor STOLL ,  Min WANG ,  Song YANG

IPC分类号： C07D487/04 ,  A61P31/04

CPC分类号： C07D487/04 ,  A61P31/04

摘要： The invention provides novel imidazopyrazine derivatives having the general formula (I), or pharmaceutically acceptable salts thereof, wherein X, m, n, and R1 to R3 are as described herein:




Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20230133845A1

公开(公告)日：2023-05-04

申请号：US17865192

申请日：2022-07-14

申请人： Hoffmann-La Roche Inc.

发明人： Mathis BRAENDLIN ,  Sandra Marie Joseph GRALL-ULSEMER ,  Xingchun HAN ,  Christian LERNER ,  Mingming LI ,  Yongqiang LIU ,  Sébastien SCHMITT ,  Jianhua WANG ,  Yongguang WANG ,  Min WANG ,  Song YANG ,  Chengang ZHOU

IPC分类号： C07D401/14 ,  C07D403/10 ,  C07D403/14 ,  A61P31/04

摘要： The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X, D, R1 to R4, and R6 to R10 are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.