公开(公告)号：US20030072790A1

公开(公告)日：2003-04-17

申请号：US09982565

申请日：2001-10-16

Applicant: Industrial Technology Research Institute

Inventor： Chin-Chin Tsai ,  Hsi-Hsin Shih ,  Huey-Min Lai

IPC: A61K009/70 ,  D04H013/00

CPC classification number: A61L27/58 ,  A61L27/48 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/604 ,  Y10T442/608

Abstract: A biodegradable porous device for tissue engineering is disclosed, which comprises (A) a porous polymeric scaffold comprising a co-continuous phase of a first biodegradable polymer and a second biodegradable polymer which are incompatible with each other, wherein the first biodegradable polymer contains a continuous network of large, interconnected pores, and the second biodegradable polymer contains small, partially interconnected pores; (B) a biodegradable polymer fiber dispersed in, and compatible with the matrix of the first biodegradable polymer; and optionally (C) an active ingredient provided in the polymeric scaffold.

Abstract translation: 公开了用于组织工程的可生物降解的多孔装置，其包括（A）包含彼此不相容的第一可生物降解聚合物和第二可生物降解聚合物的共连续相的多孔聚合物支架，其中所述第一可生物降解聚合物包含连续 大的相互连通的孔的网络，第二可生物降解的聚合物包含小的部分互连的孔; （B）分散在第一可生物降解的聚合物基质中并与其相容的可生物降解的聚合物纤维; 和任选地（C）在聚合物支架中提供的活性成分。

公开(公告)号：US20030153638A1

公开(公告)日：2003-08-14

申请号：US10000654

申请日：2001-11-01

Applicant: Industrial Technology Research Institute

Inventor： Huey-Min Lai ,  Kuang-Rong Lee ,  Chin-Chin Tsai ,  Hsi-Hsin Shih ,  Yuan-Chia Chang

IPC: C08J009/00

CPC classification number: C08J9/40 ,  C08J3/24 ,  C08J9/405 ,  C08J2201/032 ,  C08J2203/08 ,  Y02P20/544

Abstract: The present invention relates to crosslinking of porous materials made of biodegradable polymers. The method comprises: (a) placing a porous biodegradable polymer in a chamber; (b) introducing a supercritical fluid containing a crosslinking agent into the chamber to effect crosslinking of the porous biodegradable polymer; and optionally (c) introducing a pure supercritical into the chamber to wash the crosslinked polymer until the crosslinking agent is substantially removed from the polymer.

公开(公告)号：US20030064156A1

公开(公告)日：2003-04-03

申请号：US09947182

申请日：2001-09-04

Applicant: Industrial Technology Research Institute

Inventor： Hsi-Hsin Shih ,  Kuang-Rong Lee ,  Huey-Min Lai ,  Chin-Chin Tsai ,  Yuan-Chia Chang

IPC: B05D003/10

CPC classification number: C08J9/122 ,  A61L27/56 ,  A61L27/58 ,  C08J2201/032 ,  C08J2203/06 ,  C08J2203/08 ,  C08J2389/00 ,  Y02P20/544

Abstract: A method of making a porous biodegradable polymer is disclosed, which comprises (a) placing a biodegradable polymer and a solvent in a chamber; (b) adding a supercritical fluid to the chamber and maintaining the chamber at a predetermined temperature for a sufficient period of time to allow the supercritical fluid to dissolve into the biodegradable polymer with the help of the solvent; and (c) venting the supercritical fluid and the solvent by reducing the pressure in the chamber, thereby obtaining a porous biodegradable polymer.

Abstract translation: 公开了制备多孔生物可降解聚合物的方法，其包括（a）将可生物降解的聚合物和溶剂置于室中; （b）将超临界流体加入到室中并将室维持在预定温度足够的时间以允许超临界流体借助溶剂溶解到可生物降解的聚合物中; 和（c）通过降低室中的压力来排出超临界流体和溶剂，从而获得多孔生物可降解聚合物。

公开(公告)号：US20040080070A1

公开(公告)日：2004-04-29

申请号：US10669697

申请日：2003-09-25

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Hsin-Chu Liu ,  Hsi-Hsin Shih ,  Chin-Chin Tsai ,  Chien-Tsung Wu ,  Wen-Bing Liu

IPC: B29C044/02

CPC classification number: B29C44/348 ,  B29C44/3453 ,  C08J2201/032 ,  C08J2203/08 ,  C08J2203/10

Abstract: A method of manufacturing polymeric foam. The invention is related to a method of manufacturing polymeric foam by allowing supercritical fluids to diffuse into polymeric material placed in a mold directly through the mold to impregnate the polymeric material.

Abstract translation: 一种制造聚合物泡沫的方法。 本发明涉及通过使超临界流体通过模具直接扩散到模具中的聚合材料中以浸渍聚合物材料来制造聚合物泡沫体的方法。