公开(公告)号：US20200375873A1

公开(公告)日：2020-12-03

申请号：US16730564

申请日：2019-12-30

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Ting-Yu SHIH ,  Lu-Chih WANG ,  Yuan-Kun YU ,  Yi-Ting HSIEH ,  Yu-Chun LIU ,  Jing-Wen TANG

IPC: A61K8/73 ,  A61K8/02 ,  A61K8/49 ,  A61K8/06 ,  A61K8/96 ,  A61Q19/08 ,  A61K8/04 ,  A61K9/107 ,  A61K31/728 ,  A61K9/00 ,  A61K31/4172 ,  A61K31/375 ,  A61K8/67 ,  A61K31/015

Abstract: A method for skin care and/or maintenance including applying or administering a preparation to a subject is provided. The preparation includes a biomedical composition, and the biomedical composition includes an effective amount of micelle, wherein the micelle includes a hyaluronic acid and/or a derivative thereof and a modified histidine. The modified histidine is grafted to at least one primary hydroxyl group of the hyaluronic acid and/or the derivative thereof, and a graft ratio of the modified histidine is 1-100%. Moreover, the hyaluronic acid and/or the derivative thereof and the modified histidine form the micelle on a weight percentage of 0.2-300:1.

公开(公告)号：US20210198409A1

公开(公告)日：2021-07-01

申请号：US17133872

申请日：2020-12-24

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Ting-Yu SHIH ,  Chia-Chun WANG ,  Lu-Chih WANG ,  Yuan-Kun YU ,  Shu-Fang CHIANG ,  Yi-Ting HSIEH ,  Yu-Chun LIU ,  Jing-Wen TANG

IPC: C08F285/00 ,  C08F283/06

Abstract: A graft polymer is provided, which includes a polymer backbone with a plurality of hydroxy groups, protection group modified histidine grafted onto the side of the polymer backbone, and hydrophilic polymer having terminal reactive group grafted onto the side of the polymer backbone. The graft polymer coating can be applied to metal material to form a composite material, which can be implanted into an organism to reduce adhesion problems.

公开(公告)号：US20150118322A1

公开(公告)日：2015-04-30

申请号：US14514137

申请日：2014-10-14

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Ya-Chin LO ,  Hsiang-Fa LIANG ,  Ming-Cheng WEI ,  Maggie J.M. LU ,  Min-Ying LIN ,  Chih-Peng LIU ,  Chun-MIN LIU ,  Hsiang-Wen TSENG ,  Tse-Min TENG ,  Jui-Hsiang CHEN ,  Yi-Man CHOU ,  Yi-Ting HSIEH ,  Chia-Mu TU

IPC: C08B37/08 ,  A61K33/24 ,  A61K31/4745 ,  A61K31/7036 ,  A61K47/48 ,  A61K31/704

CPC classification number: A61K33/24 ,  A61K31/4172 ,  A61K31/4745 ,  A61K31/555 ,  A61K31/7036 ,  A61K31/704 ,  A61K31/728 ,  A61K45/06 ,  A61K47/542 ,  A61K47/61 ,  A61K47/6921 ,  A61K2300/00

Abstract: The disclosure provides a biomedical composition, including: a hyaluronic acid; a modified histidine; and a polymer or C4-C20 alkane, wherein the modified histidine and the polymer or C4-C20 alkane are grafted to at least one primary hydroxyl group of the hyaluronic acid to allow the hyaluronic acid to form a hyaluronic acid derivative, wherein a graft ratio of the modified histidine is about 1-100%, and a graft ratio of the polymer or C4-C20 alkane is about 0-40%.

Abstract translation: 本公开提供了一种生物医学组合物，其包括：透明质酸; 修饰的组氨酸 和聚合物或C 4 -C 20烷烃，其中将经修饰的组氨酸和聚合物或C 4 -C 20烷烃接枝至透明质酸的至少一个伯羟基，以使透明质酸形成透明质酸衍生物，其中接枝率 的改性组氨酸约为1-100％，聚合物或C4-C20烷烃的接枝率约为0-40％。