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    Method of managing urolithiasis and related urological disorders
    3.
    发明授权
    Method of managing urolithiasis and related urological disorders 有权
    尿路结石和相关泌尿系统疾病的治疗方法

    公开(公告)号：US09241937B2

    公开(公告)日：2016-01-26

    申请号：US14439657

    申请日：2013-10-31

    Applicant: INDUS BIOTECH PRIVATE LIMITED

    Inventor： Sunil Bhaskaran ,  Mohan Vishwaraman

    IPC: A61K31/455 ,  A61K31/198

    CPC classification number: A61K31/455 ,  A61K31/198 ,  A61K2300/00

    Abstract: The present disclosure relates to a method of managing urolithiasis or related urological disorders in a subject in need thereof, using pharmaceutical composition comprising trigonelline or its derivative(s) and 4-hydroxyisoleucine or its derivative(s), optionally along with excipient(s).

    Abstract translation: 本公开涉及在有需要的受试者中使用包含葫芦巴林或其衍生物和4-羟基异亮氨酸或其衍生物的药物组合物，任选地与赋形剂一起治疗在有需要的受试者中的尿石症或相关泌尿系统疾病的方法， 。

    METHOD OF MANAGING UROLITHIASIS AND RELATED UROLOGICAL DISORDERS
    5.
    发明申请
    METHOD OF MANAGING UROLITHIASIS AND RELATED UROLOGICAL DISORDERS 有权
    治疗尿路感染和相关性尿毒症的方法

    公开(公告)号：US20150283126A1

    公开(公告)日：2015-10-08

    申请号：US14439657

    申请日：2013-10-31

    Applicant: INDUS BIOTECH PRIVATE LIMITED

    Inventor： Sunil Bhaskaran ,  Mohan Vishwaraman

    IPC: A61K31/455 ,  A61K31/198

    CPC classification number: A61K31/455 ,  A61K31/198 ,  A61K2300/00

    Abstract: The present disclosure relates to a method of managing urolithiasis or related urological disorders in a subject in need thereof, using pharmaceutical composition comprising trigonelline or its derivative(s) and 4-hydroxyisoleucine or its derivative(s), optionally along with excipient(s).

    Abstract translation: 本公开涉及在有需要的受试者中使用包含葫芦巴林或其衍生物和4-羟基异亮氨酸或其衍生物的药物组合物，任选地与赋形剂一起治疗在有需要的受试者中的尿石症或相关泌尿系统疾病的方法， 。

    METHOD OF MANAGING DIABETIC FOOT ULCERS, PRESSURE ULCERS, VENOUS LEG ULCERS AND ASSOCIATED COMPLICATION
    6.
    发明申请
    METHOD OF MANAGING DIABETIC FOOT ULCERS, PRESSURE ULCERS, VENOUS LEG ULCERS AND ASSOCIATED COMPLICATION 审中-公开
    管理糖尿病患者的方法，压力ULCERS，VENOUS LEG ULCERS和相关联合

    公开(公告)号：US20150182494A1

    公开(公告)日：2015-07-02

    申请号：US14420252

    申请日：2013-08-06

    Applicant: INDUS BIOTECH PRIVATE LIMITED

    Inventor： Sunil Bhaskaran ,  Mohan Vishwaraman

    IPC: A61K31/353

    CPC classification number: A61K31/353 ,  A61K9/4866

    Abstract: The present disclosure is related to a method of managing diabetic foot ulcers (DFUs), pressure ulcers, venous leg ulcers and associated complications such as bacterial infection, gangrene, tissue necrosis, amputation, proximal limb loss and septicaemia. This method of managing is by administration of pharmaceutical composition comprising pentameric type A procyanidin, trimeric procyanidin and tetrameric procyanidin, optionally along with pharmaceutically acceptable excipient.

    Abstract translation: 本公开涉及一种治疗糖尿病足溃疡（DFU），压力性溃疡，静脉性腿部溃疡以及相关并发症如细菌感染，坏疽，组织坏死，截肢，近端肢体损失和败血症的方法。 这种管理方法是通过施用包含五聚体A型原花青素，三聚原花青素和四聚原花青素的药物组合物，任选地与药学上可接受的赋形剂一起施用。

    COMPLEX OF GARCINOL, CYCLODEXTRIN AND METHOD THEREOF
    8.
    发明申请
    COMPLEX OF GARCINOL, CYCLODEXTRIN AND METHOD THEREOF 有权
    葡萄糖苷，环糊精的复合物及其方法

    公开(公告)号：US20150196669A1

    公开(公告)日：2015-07-16

    申请号：US14593882

    申请日：2015-01-09

    Applicant: Indus Biotech Private Limited

    Inventor： Sunil Bhaskaran ,  Mohan Vishwaraman

    IPC: A61K47/48 ,  C07C45/79 ,  A61K31/122

    CPC classification number: A61K47/6951 ,  A61K31/122 ,  B82Y5/00 ,  C07B2200/01 ,  C07C45/79 ,  C07C49/835 ,  C07C2602/46 ,  C08B37/0015

    Abstract: The present disclosure discloses a pharmaceutical molecule of Garcinol chemically complexed with cyclodextrins and the use of the complexed molecule in prevention and management of cardiac dysfunction induced by chemotherapy, drugs and/or other insults to the heart caused by lifestyle and disease conditions. The disclosure also relates to a method of extraction and purification of high yield of 95-99% pure Garcinol from Garcinia species and a method of chemically complexing Garcinol with cyclodextrins to improve its stability and bioavailability.

    Abstract translation: 本公开公开了一种与环糊精化学络合的Garcinol的药物分子，以及复合分子在预防和控制由生理和疾病状况引起的由化学疗法，药物和/或其他侮辱引起的心脏功能障碍中的用途。 本公开还涉及从藤黄属物种中提取和纯化高产量的95-99％纯的Garcinol的方法，以及将Garcinol与环糊精化学络合以提高其稳定性和生物利用度的方法。

    Method of managing Hepatic fibrosis, Hepatitis C virus and associated condition
    9.
    发明授权
    Method of managing Hepatic fibrosis, Hepatitis C virus and associated condition 有权

    公开(公告)号：US09775826B2

    公开(公告)日：2017-10-03

    申请号：US14891746

    申请日：2014-05-19

    Applicant: INDUS BIOTECH PRIVATE LIMITED

    Inventor： Sunil Bhaskaran ,  Mohan Vishwaraman

    IPC: A61K31/353 ,  A61K9/48

    CPC classification number: A61K31/353 ,  A61K9/4866

    Abstract: The present disclosure relates to management of Hepatitis C Virus (HCV) and associated condition. The present disclosure also relates to management of Hepatic Fibrosis. The present disclosure relates to administration of composition comprising pentameric type A procyanidin, trimeric procyanidin and tetrameric procyanidin, optionally along with pharmaceutically acceptable excipient, for management of Hepatic Fibrosis, Hepatitis C virus and associated conditions. The composition acts as an inhibitor at the entry stage of Hepatitis C virus into a cell. The composition inhibits different genotypes of Hepatitis C Virus.

    METHOD FOR PREPARATION OF HIGHLY PURE ASIATICOSIDE COMPOSITION FROM CENTELLA ASIATICA AND A METHOD OF USE THEREOF
    10.
    发明申请
    METHOD FOR PREPARATION OF HIGHLY PURE ASIATICOSIDE COMPOSITION FROM CENTELLA ASIATICA AND A METHOD OF USE THEREOF 审中-公开
    从中国科学院制备高纯度亚硫酸酯组合物的方法及其使用方法

    公开(公告)号：US20150342976A1

    公开(公告)日：2015-12-03

    申请号：US14824732

    申请日：2015-08-12

    Applicant: Indus Biotech Private Limited

    Inventor： Sunil Bhaskaran ,  Mohan Vishwaraman

    IPC: A61K31/7028

    CPC classification number: A61K31/7028 ,  A61K31/702 ,  A61K36/23 ,  C07H1/08

    Abstract: Disclosed is a commercially viable asiaticoside composition having at least 99% purity that is derived from plant Centella asiatica and a manufacturing process thereof. Also disclosed is a method and the models for oral administration of therapeutically effective amounts of the asiaticoside composition for treatment of Inflammatory Bowel Diseases such as Ulcerative colitis, Crohn's disease and associated complications of inflammatory bowel diseases such as hemorrhoids, anal fissures, fistulas. Also disclosed is a method and model for oral administration of therapeutically effective amounts of the asiaticoside composition for treatment of Helicobacter Pylori, as well as a method and the models for oral administration of therapeutically effective amounts of the asiaticoside composition for prevention of colon cancer, gastric diseases and gastric carcinoma.

    Abstract translation: 公开了一种商业上可行的积雪草苷组合物，其具有源自植物积雪草的至少99％的纯度及其制造方法。 还公开了一种用于口服给药治疗有效量的积雪草苷组合物用于治疗炎症性肠病如溃疡性结肠炎，克罗恩病以及炎性肠病如痔疮，肛裂，瘘等相关并发症的方法和模型。 还公开了用于口服给药治疗有效量的用于治疗幽门螺杆菌的积雪草苷组合物的方法和模型，以及用于口服施用治疗有效量的积雪草苷组合物用于预防结肠癌，胃癌的方法和模型 疾病和胃癌。

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