公开(公告)号：US12162827B2

公开(公告)日：2024-12-10

申请号：US17630130

申请日：2019-07-26

Applicant: UNIVERSITA' DEGLI STUDI DI CAGLIARI

Inventor： Dario Piano ,  Domenica Farci

IPC: C07C45/79 ,  C07C7/00 ,  C07C7/10 ,  C07C7/12

Abstract: The present invention relates to a method for the production of chromoplastid carotenoids that can be isolated from fruits. The procedure of the invention allows to selectively isolate, on the basis of the size (Size Exclusion Chromatography) and in pure form, the carotenoid in the form of regularly shaped and sized aggregates. The process includes the following steps: i) production, in suspension, of homogeneous fragments of the chromoplastidial membranes from the fruits; ii) solution isolation of the membrane components by solubilization with detergents; iii) selective and high-purity isolation of the carotenoid in the form of regular paracrystalline aggregates by a screening technique such as size exclusion chromatography (SEC—Size Exclusion Chromatography).

公开(公告)号：US20230130823A1

公开(公告)日：2023-04-27

申请号：US17771124

申请日：2020-10-23

Applicant: ANHANGUERA EDUCACIONAL PARTICIPAÇÕES S/A ,  FUNDAÇÃO UNIVERSIDADE FEDERAL DO ABC ,  INSTITUTO BUTANTAN

Inventor： Anderson ORZARI RIBEIRO ,  Carolina PASSARELLI GONÇALVES ,  Durvanei AUGUSTO MARIA ,  José Agustín QUINCOCES SUÁREZ ,  Manuel SALUSTIANO ALMEIDA SAAVEDRA

IPC: C07C319/14 ,  C07C323/27 ,  C07C319/28 ,  C07C253/30 ,  C07C255/38 ,  C07C253/34 ,  C07C201/12 ,  C07C201/16 ,  C07C205/41 ,  C07C67/40 ,  C07C67/58 ,  C07C69/94 ,  C07C45/45 ,  C07C45/79 ,  C07C49/235 ,  C07C255/35 ,  C07C205/09 ,  C07C255/40 ,  C07C49/255

Abstract: The present invention reports the obtaining of carbonyl compounds and derivatives, through syntheses with high yield and purity, providing anti-humoral active principles with selective antiproliferative properties and anti-metastatic activity.
The present invention refers to the development of new polyfunctional push-pull butadienes and their O and C-prenylated, benzoylated and iodide derivatives, with high electronic conjugation in the lateral chain. These compounds exhibit high anti-tumor selectivity, causing cell death by apoptosis, also show anti-metastatic and non-mutagenic properties in the experimental studies performed.

公开(公告)号：US11022350B2

公开(公告)日：2021-06-01

申请号：US16384117

申请日：2019-04-15

Applicant: Supercritical Fluid Technologies, Inc.

Inventor： Kenneth Joseph James ,  Brian Jeffrey Waibel ,  Kenneth Richard Krewson ,  Chinedu David Chikwem ,  Daniel Alan Brisach ,  Kim Ferrera ,  Curtis Ebersold

IPC: F25B25/00 ,  F25B9/00 ,  F25B49/02 ,  G01N30/30 ,  G01N30/54 ,  F25B7/00 ,  B01D15/16 ,  B01D15/40 ,  B04C5/081 ,  B04C5/085 ,  B04C9/00 ,  C07C45/79 ,  C07C51/47 ,  C07C67/56 ,  C07C231/24 ,  C09K5/04 ,  F25B9/10 ,  G01N30/20

Abstract: Provided is a chiller and system that may be utilized in a supercritical fluid chromatography method, wherein a non-polar solvent may replace a portion or all of a polar solvent for the purpose of separating or extracting desired sample molecules from a combined sample/solvent stream. The system may reduce the amount of polar solvent necessary for chromatographic separation and/or extraction of desired samples. The system may incorporate a supercritical fluid chiller, a supercritical fluid pressure-equalizing vessel and a supercritical fluid cyclonic separator. The supercritical fluid chiller allows for efficient and consistent pumping of liquid-phase gases employing off-the-shelf HPLC pumps. The pressure equalizing vessel allows the use of off-the-shelf HPLC column cartridges. The system may further incorporate the use of one or more disposable cartridges containing silica gel or other suitable medium. The system may also utilize an open loop cooling circuit using fluids with a positive Joule-Thompson coefficient.

公开(公告)号：US20210002200A1

公开(公告)日：2021-01-07

申请号：US17000506

申请日：2020-08-24

Applicant: SYMRISE AG ,  SINO-HIGH (CHINA) CO. LTD.

Inventor： Ravikumar Pillai ,  Sven Siegel ,  Ev Suess ,  Karolin Bolte ,  Yan Liuxin

IPC: C07C45/81 ,  C07C45/79

Abstract: Methods of purifying crude 4-hydroxyacetophenone using one or more solvents as well as products comprising or consisting of crystallized 4-hydroxyacetophenone and one, two or more solvent(s). The products may be obtained or obtainable from the methods for purifying crude 4-hydroxyacetophenone.

公开(公告)号：US20200181054A1

公开(公告)日：2020-06-11

申请号：US16316644

申请日：2017-07-12

Applicant: SABIC Global Technologies B.V.

Inventor： Syed Azhar Hashmi ,  Salkod Parameshwar Mallika ,  Flaiyh Al-Anazi

IPC: C07C45/79 ,  B01J41/05 ,  B01J41/20 ,  B01J41/14 ,  B01J47/02 ,  B01D15/36

Abstract: A method for purifying acetone includes contacting an initial solution with a basic ion-exchange resin at a temperature of 15° C. to 30° C., wherein the initial solution comprises acetone and acetone impurities; and removing the acetone impurities from the initial solution with the basic ion-exchange resin to produce a purified solution.

公开(公告)号：US20200016508A1

公开(公告)日：2020-01-16

申请号：US16510206

申请日：2019-07-12

Applicant: Bright Green Corporation

Inventor： V. Hari ,  John Stockwell

IPC: B01D11/02 ,  C07C45/79 ,  C07D311/78 ,  C07C37/82 ,  C07J17/00 ,  B01D15/08 ,  B01D11/04 ,  H01J49/00

Abstract: An example method for extracting phytochemical oil from plant parts includes freezing plant parts from at least one of Cannabis sativa, Curcuma longa, Panax ginseng, and Panax quinquefolius. The frozen plant parts are reduced to a plant powder, which is suspended in an aqueous buffer. The aqueous buffer containing the suspended plant powder is incubated with at least one pectinase and at least one cellulose. An aqueous phase of the incubated aqueous buffer is evaporated through steam heating to obtain a steam dried product. Phytochemical oil, which includes at least one of cannabinoids, curcuminoids, and ginsenosides, is extracted from the steam dried product.

公开(公告)号：US10344125B2

公开(公告)日：2019-07-09

申请号：US15982549

申请日：2018-05-17

Applicant: ARKEMA FRANCE

Inventor： Guillaume Le ,  Julien Jouanneau ,  Jérôme Amstutz

IPC: C07C41/00 ,  C08G65/00 ,  C08G65/40 ,  C07C49/84 ,  C07C41/36 ,  C07C7/148 ,  C07C45/46 ,  C07C45/80 ,  C07C45/79

Abstract: A method for manufacturing 1,4-bis(4-phenoxybenzoylbenzene), including: reacting terephthaloyl chloride with diphenyl ether in a reaction solvent and in the presence of a Lewis acid, so as to obtain a product mixture including a 1,4-bis(4-phenoxybenzoylbenzene)-Lewis acid complex; contacting the product mixture with a protic solvent, so as to obtain a first phase containing the Lewis acid and a second phase containing 1,4-bis(4-phenoxybenzoylbenzene); subjecting at least the second phase to a solid/liquid separation step by centrifugal filtration, so as to recover solid 1,4-bis(4-phenoxybenzoylbenzene).

公开(公告)号：US09956301B2

公开(公告)日：2018-05-01

申请号：US14593882

申请日：2015-01-09

Applicant: Indus Biotech Private Limited

Inventor： Sunil Bhaskaran ,  Mohan Vishwaraman

IPC: A61K31/122 ,  A61K47/48 ,  C07C45/79 ,  B82Y5/00 ,  C07C49/835 ,  C08B37/16 ,  A61K47/69

CPC classification number: A61K47/6951 ,  A61K31/122 ,  B82Y5/00 ,  C07B2200/01 ,  C07C45/79 ,  C07C49/835 ,  C07C2602/46 ,  C08B37/0015

Abstract: The present disclosure discloses a pharmaceutical molecule of Garcinol chemically complexed with cyclodextrins and the use of the complexed molecule in prevention and management of cardiac dysfunction induced by chemotherapy, drugs and/or other insults to the heart caused by lifestyle and disease conditions. The disclosure also relates to a method of extraction and purification of high yield of 95-99% pure Garcinol from Garcinia species and a method of chemically complexing Garcinol with cyclodextrins to improve its stability and bioavailability.

公开(公告)号：US20180112896A1

公开(公告)日：2018-04-26

申请号：US15784131

申请日：2017-10-14

Applicant: Supercritical Fluid Technologies, Inc.

Inventor： Kenneth Joseph James ,  Brian Jeffrey Waibel ,  Kenneth Richard Krewson ,  Chinedu David Chikwem ,  Daniel Alan Brisach ,  Kim Ferrara ,  Curtis B. Ebersold

IPC: F25B25/00 ,  B01D15/40 ,  B01D15/16 ,  B04C9/00 ,  B04C5/081 ,  B04C5/085 ,  F25B9/00 ,  F25B9/10 ,  C09K5/04 ,  C07C45/79 ,  C07C67/56 ,  C07C51/47 ,  C07C231/24

CPC classification number: F25B25/005 ,  B01D15/165 ,  B01D15/40 ,  B04C5/081 ,  B04C5/085 ,  B04C9/00 ,  B04C2009/004 ,  C07C45/79 ,  C07C51/47 ,  C07C67/56 ,  C07C231/24 ,  C09K5/041 ,  C09K2205/106 ,  C09K2205/13 ,  C09K2205/132 ,  F25B7/00 ,  F25B9/002 ,  F25B9/008 ,  F25B9/10 ,  F25B49/02 ,  F25B2600/2513 ,  F25B2700/21171 ,  G01N30/20 ,  G01N30/30 ,  G01N30/54 ,  Y02P20/544

Abstract: Provided is a chiller and system that may be utilized in a supercritical fluid chromatography method, wherein a non-polar solvent may replace a portion or all of a polar solvent for the purpose of separating or extracting desired sample molecules from a combined sample/solvent stream. The system may reduce the amount of polar solvent necessary for chromatographic separation and/or extraction of desired samples. The system may incorporate a supercritical fluid chiller, a supercritical fluid pressure-equalizing vessel and a supercritical fluid cyclonic separator. The supercritical fluid chiller allows for efficient and consistent pumping of liquid-phase gases employing off-the-shelf HPLC pumps. The pressure equalizing vessel allows the use of off the shelf HPLC column cartridges. The system may further incorporate the use of one or more disposable cartridges containing silica gel or other suitable medium. The system may also utilize an open loop cooling circuit using fluids with a positive Joule-Thompson coefficient.

公开(公告)号：US20170275226A1

公开(公告)日：2017-09-28

申请号：US15504217

申请日：2015-08-03

Applicant: ExxonMobil Chemical Patents Inc.

Inventor： Keith H. Kuechler ,  Jörg F.W. Weber ,  Ashley J. Poucher ,  Jason D. Davis ,  Christopher L. Becker ,  Jihad M. Dakka

IPC: C07C45/00 ,  C07C45/82 ,  C07C45/79

CPC classification number: C07C45/006 ,  C07C7/005 ,  C07C7/04 ,  C07C7/12 ,  C07C37/74 ,  C07C37/82 ,  C07C45/79 ,  C07C45/82 ,  C07C2601/14 ,  Y02P20/52 ,  C07C49/403 ,  C07C39/04 ,  C07C13/28

Abstract: Disclosed are processes for making cyclohexanone from a mixture comprising phenol, cyclohexanone, cyclohexylbenzene, and an S-containing component, comprising a step of removing at least a portion of the S-containing component to reduce poisoning of a hydrogenation catalyst used for hydrogenating phenol to cyclohexanone.