公开(公告)号：US20240190801A1

公开(公告)日：2024-06-13

申请号：US18550801

申请日：2022-03-14

Applicant: SPECIALTY OPERATIONS FRANCE

Inventor： Talsida Zougmore ,  Rachid Djillali ,  Laurent Garel

IPC: C07C45/81 ,  C07C45/79 ,  C07C45/80 ,  C12P7/24

CPC classification number: C07C45/81 ,  C07C45/79 ,  C07C45/80 ,  C12P7/24

Abstract: The present invention relates to a process for purifying vanillin or derivatives thereof obtained via a biotechnological process, comprising at least one step in which vanillin or derivatives thereof are separated from vanillyl alcohol or derivatives thereof by crystallization.

公开(公告)号：US11981630B1

公开(公告)日：2024-05-14

申请号：US18103843

申请日：2023-01-31

Applicant: Hangzhou Normal University

Inventor： Mingfeng Xu ,  Xiaohong Deng ,  Jinfeng Liang ,  Yidi Chen ,  Jing Ren ,  Qin Zhu

IPC: C07C49/747 ,  A61P35/02 ,  C07C45/79

CPC classification number: C07C49/747 ,  A61P35/02 ,  C07C45/79 ,  C07C2603/26

Abstract: Disclosed are an abietane type diterpene compound, a preparation method and an application thereof, relating to the technical field of anti-tumor compounds, where the compound has a chemical structure as shown in the following formula I:




Leucosceptrum canum is extracted to prepare the abietane type diterpene compound according to the present application, and the prepared compound is effectively applied in inhibiting human lung cancer cell A549 and human myeloid leukemia cell HL-60.

公开(公告)号：US11913685B2

公开(公告)日：2024-02-27

申请号：US17506353

申请日：2021-10-20

Applicant: Supercritical Fluid Technologies, Inc.

Inventor： Kenneth Joseph James ,  Brian Jeffrey Waibel ,  Kenneth Richard Krewson ,  Kim Ferrara ,  Curtis Ebersold

IPC: F25B7/00 ,  F25B9/00 ,  F25B9/10 ,  F25B25/00 ,  F25B49/02 ,  G01N30/20 ,  G01N30/30 ,  G01N30/54 ,  B01D15/16 ,  B01D15/40 ,  B04C5/081 ,  B04C5/085 ,  C07C45/79 ,  C07C51/47 ,  C07C231/24 ,  C09K5/04 ,  B04C9/00 ,  C07C67/56

CPC classification number: F25B25/005 ,  B01D15/165 ,  B01D15/40 ,  B04C5/081 ,  B04C5/085 ,  B04C9/00 ,  C07C45/79 ,  C07C51/47 ,  C07C67/56 ,  C07C231/24 ,  C09K5/041 ,  F25B7/00 ,  F25B9/002 ,  F25B9/008 ,  F25B9/10 ,  F25B49/02 ,  G01N30/30 ,  G01N30/54 ,  B04C2009/004 ,  C09K2205/106 ,  C09K2205/13 ,  C09K2205/132 ,  F25B2600/2513 ,  F25B2700/21171 ,  G01N30/20 ,  Y02P20/54

Abstract: Provided is a chiller and system that may be utilized in a supercritical fluid chromatography method, wherein a non-polar solvent may replace a portion or all of a polar solvent for the purpose of separating or extracting desired sample molecules from a combined sample/solvent stream. The system may reduce the amount of polar solvent necessary for chromatographic separation and/or extraction of desired samples. The system may incorporate a supercritical fluid chiller, a supercritical fluid pressure-equalizing vessel and a supercritical fluid cyclonic separator. The supercritical fluid chiller allows for efficient and consistent pumping of liquid-phase gases employing off-the-shelf HPLC pumps. The pressure equalizing vessel allows the use of off-the-shelf HPLC column cartridges. The system may further incorporate the use of one or more disposable cartridges containing silica gel or other suitable medium. The system may also utilize an open loop cooling circuit using fluids with a positive Joule-Thomson coefficient.

公开(公告)号：US20190055259A1

公开(公告)日：2019-02-21

申请号：US16078292

申请日：2017-03-09

Applicant: Mitsubishi Gas Chemical Company, Inc.

Inventor： Masahiro YAMANE

IPC: C07D493/10 ,  C07C45/45 ,  C07C45/80 ,  C07C45/82 ,  C07C45/81 ,  C07C45/79 ,  C07D319/06

CPC classification number: C07D493/10 ,  C07C45/45 ,  C07C45/79 ,  C07C45/80 ,  C07C45/81 ,  C07C45/82 ,  C07D319/06

Abstract: The present invention provides a method for producing a diol having a cyclic acetal skeleton, in which the method include an acetalization reaction step of obtaining a diol having a cyclic acetal skeleton by subjecting raw material hydroxypivalaldehyde and at least pentaerythritol and/or trimethylolpropane to an acetalization reaction under an acid catalyst and the raw material hydroxypivalaldehyde can contain a prescribed amount of at least one impurity selected from the group consisting of formaldehyde, neopentyl glycol, an ester compound having a neopentyl glycol skeleton represented by formula (III), and isobutyraldehyde.

公开(公告)号：US10053411B2

公开(公告)日：2018-08-21

申请号：US15827173

申请日：2017-11-30

Applicant: EVONIK DEGUSSA GMBH

Inventor： Tarek Dishisha ,  Rajni Hatti Kaul ,  Roya R. R. Sardari ,  Bastian Grund ,  Oliver Thum

IPC: C07C45/79

CPC classification number: C07C45/79 ,  C12P7/24 ,  C12Y402/0103 ,  C07C47/19

Abstract: The present invention relates to a method of extracting 3-hydroxypropionaldehyde (3-HPA) and/or derivatives thereof from an aqueous solution comprising 3-HPA, the method comprising: (a) contacting the aqueous solution with chitosan and/or chitosan comprising polymers; (b) separating the 3-HPA bound chitosan and/or chitosan comprising polymers; and (c) washing the 3-HPA bound chitosan and/or chitosan comprising polymers at least once with a washing medium; wherein 3-HPA and/or derivatives thereof is in the washing medium.

公开(公告)号：US20180057438A1

公开(公告)日：2018-03-01

申请号：US15687608

申请日：2017-08-28

Applicant: NAN YA PLASTICS CORPORATION

Inventor： Te-Chao LIAO ,  Jung-Jen CHUANG ,  Chung-Yu CHEN ,  Chia-Ruey TSAI ,  Sung-Chieh CHAO

IPC: C07C45/62 ,  C07C45/79 ,  B01J23/44 ,  B01J21/18 ,  B01J35/00 ,  B01J35/02

CPC classification number: C07C45/62 ,  B01J21/18 ,  B01J23/44 ,  B01J35/0006 ,  B01J35/026 ,  B01J35/1023 ,  B01J35/1028 ,  C07C45/79 ,  C07C47/02

Abstract: A process for producing 2-ethylhexanal involves performing reaction using a reaction tank equipped with a gas-introducing mixer having extracting, exhausting, and stirring functions in the presence of a palladium on carbon catalyst having a carbon carrier with lower impurity content and higher specific surface area for hydrogenation, and introducing hydrogen gas evenly into reaction liquid; resulted in that the process minimizes operational pressure for hydrogenation and increases a yield of 2-ethylhexanal at least up to 98.0%.

公开(公告)号：US20170204037A1

公开(公告)日：2017-07-20

申请号：US15324671

申请日：2015-08-03

Applicant: ExxonMobil Chemical Patents Inc.

Inventor： Christopher L. BECKER ,  Jason D. DAVIS ,  Jihad M. DAKKA ,  Kirk C. NADLER

IPC: C07C45/82

CPC classification number: C07C45/006 ,  C07C7/005 ,  C07C7/04 ,  C07C7/12 ,  C07C37/74 ,  C07C37/82 ,  C07C45/79 ,  C07C45/82 ,  C07C2601/14 ,  Y02P20/52 ,  C07C49/403 ,  C07C39/04 ,  C07C13/28

Abstract: Disclosed are processes for making cyclohexanone from a mixture comprising phenol, cyclohexanone, cyclohexylbenzene, and a catalyst poison component, comprising a step of removing at least a portion of the catalyst poison component to reduce poisoning of a hydrogenation catalyst used for hydrogenating phenol to cyclohexanone.

公开(公告)号：US20150196669A1

公开(公告)日：2015-07-16

申请号：US14593882

申请日：2015-01-09

Applicant: Indus Biotech Private Limited

Inventor： Sunil Bhaskaran ,  Mohan Vishwaraman

IPC: A61K47/48 ,  C07C45/79 ,  A61K31/122

CPC classification number: A61K47/6951 ,  A61K31/122 ,  B82Y5/00 ,  C07B2200/01 ,  C07C45/79 ,  C07C49/835 ,  C07C2602/46 ,  C08B37/0015

Abstract: The present disclosure discloses a pharmaceutical molecule of Garcinol chemically complexed with cyclodextrins and the use of the complexed molecule in prevention and management of cardiac dysfunction induced by chemotherapy, drugs and/or other insults to the heart caused by lifestyle and disease conditions. The disclosure also relates to a method of extraction and purification of high yield of 95-99% pure Garcinol from Garcinia species and a method of chemically complexing Garcinol with cyclodextrins to improve its stability and bioavailability.

Abstract translation: 本公开公开了一种与环糊精化学络合的Garcinol的药物分子，以及复合分子在预防和控制由生理和疾病状况引起的由化学疗法，药物和/或其他侮辱引起的心脏功能障碍中的用途。 本公开还涉及从藤黄属物种中提取和纯化高产量的95-99％纯的Garcinol的方法，以及将Garcinol与环糊精化学络合以提高其稳定性和生物利用度的方法。

公开(公告)号：US09006494B2

公开(公告)日：2015-04-14

申请号：US13934806

申请日：2013-07-03

Applicant: BASF SE ,  Johannes-Gutenberg-Universität

Inventor： Florian Stecker ,  Andreas Fischer ,  Axel Kirste ,  Agnes Voitl ,  Chung Huan Wong ,  Siegfried Waldvogel ,  Carolin Regenbrecht ,  Dominik Schmitt ,  Marius Franziskus Hartmer

IPC: C07C45/79

CPC classification number: C07C45/79 ,  C07C47/58

Abstract: The present invention relates to a process for producing vanillin from an aqueous, basic vanillin-comprising composition, in particular from a composition as arises in the oxidation, especially in the oxidation by electrolysis, of aqueous alkaline lignin-comprising compositions, comprising at least one treatment of an aqueous, basic vanillin-comprising composition, in particular the treatment of a composition as arises in the oxidation, especially in the oxidation by electrolysis, of aqueous alkaline lignin-comprising compositions, with a basic adsorbent, in particular an anion exchanger.

Abstract translation: 本发明涉及一种由含水的碱性香草醛组合物制备香草醛的方法，特别是由氧化，特别是通过电解氧化的组合物中含有碱性木质素的水性组合物制备的，包含至少一种 特别是在碱性吸附剂，特别是阴离子交换剂中处理含水碱性香草醛组合物，特别是在氧化，特别是通过电解氧化生成含碱性含木质素的组合物中处理组合物。

公开(公告)号：US20130197097A1

公开(公告)日：2013-08-01

申请号：US13364127

申请日：2012-02-01

Applicant: WENCHANG CHIANG ,  YUEH-HSIUNG KUO ,  YUN-LIAN LIN ,  CHENG-PEI CHUNG

Inventor： WENCHANG CHIANG ,  YUEH-HSIUNG KUO ,  YUN-LIAN LIN ,  CHENG-PEI CHUNG

IPC: A61K31/122 ,  C07C45/79 ,  A61P35/00 ,  C07C49/753

CPC classification number: A61K36/8994 ,  A61K2236/00 ,  C07C45/79 ,  C07C45/80 ,  C07C49/753

Abstract: The present invention provides novel spiroenones extracted from an alcohol extract of dehulled adlay seeds. The present invention also provides a process for the preparation of the spiroenones and a method for treating breast cancer in a subject, which method comprises administering to said subject an effective amount of the spiroenone and a pharmaceutically acceptable carrier or excipient.

Abstract translation: 本发明提供从脱壳的楝树种子的醇提取物中提取的新的螺旋酮。 本发明还提供了制备螺旋酮的方法和用于治疗受试者的乳腺癌的方法，该方法包括向所述受试者施用有效量的螺螺酮和药学上可接受的载体或赋形剂。