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1.发明申请PROCESS FOR REDUCING CO2 EMISSIONS AND INCREASING ALCOHOL PRODUCTIVITY IN SYNGAS FERMENTATION 审中-公开减少二氧化碳排放和增加酒精发酵中酒精生产力的方法公开(公告)号：US20140080195A1
公开(公告)日：2014-03-20
申请号：US14017903
申请日：2013-09-04
Applicant: INEOS BIO SA
Inventor： Ryan Senaratne
IPC: C12P7/08
CPC classification number: C12Q1/04 , C12P7/065 , C12P7/08 , C12Q3/00 , G01N21/31 , G01N33/84 , Y02E50/17
Abstract: A process is provided that is effective for reducing CO2 emissions, enhancing STY and/or increasing cell density. The process allows for utilization of syngas from different sources by controlling concentration levels of CO, CO2 and H2 in syngas provided to the fermentation and by controlling relative concentrations of CO, CO2 and H2 in the syngas provided to the fermentation. The process includes providing syngas to a first fermentation zone and fermenting the syngas. If the first fermentation zone off-gas includes about 4 mole % or more CO, then at least a portion of the first fermentor off-gas is provided to one or more subsequent fermentation zones.
Abstract translation: 提供了一种有效减少二氧化碳排放，增强STY和/或增加细胞密度的方法。 该过程允许通过控制提供给发酵的合成气中的CO，CO 2和H 2的浓度水平以及通过控制提供给发酵的合成气中的CO，CO 2和H 2的相对浓度来利用来自不同来源的合成气。 该方法包括向第一发酵区提供合成气并发酵合成气。 如果第一发酵区废气包括约4摩尔％或更多的CO，则至少一部分第一发酵罐废气被提供给一个或多个后续的发酵区。
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2.发明授权公开(公告)号：US10233478B2
公开(公告)日：2019-03-19
申请号：US14017903
申请日：2013-09-04
Applicant: INEOS BIO SA
Inventor： Ryan Senaratne
Abstract: A process is provided that is effective for reducing CO2 emissions, enhancing STY and/or increasing cell density. The process allows for utilization of syngas from different sources by controlling concentration levels of CO, CO2 and H2 in syngas provided to the fermentation and by controlling relative concentrations of CO, CO2 and H2 in the syngas provided to the fermentation. The process includes providing syngas to a first fermentation zone and fermenting the syngas. If the first fermentation zone off-gas includes about 4 mole % or more CO, then at least a portion of the first fermentor off-gas is provided to one or more subsequent fermentation zones.
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Patent Agency Ranking
公开(公告)号：US20160040192A1
公开(公告)日：2016-02-11
申请号：US14922579
申请日：2015-10-26
Applicant: INEOS BIO SA
Inventor： Syrona R. Scott , Ryan Senaratne , Ching-Whan Ko
CPC classification number: C12P7/06 , C12N1/20 , C12P7/065 , C12P7/08 , C12P7/16 , C12P7/54 , C12P7/56 , Y02E50/17
Abstract: A process for fermenting syngas and a fermentation medium provides high ethanol productivity while removing medium components that were previously thought to be essential. The process is effective for providing a specific STY of at least about 1 g ethanol/(L-day-gram cells). In this aspect, the fermentation medium has a weight ratio of NH4+ to B of about 625:1 or more, or a weight ratio of NH4+ to Mn of about 4050:1 or more, or a weight ratio of NH/ to Mo of about 2500:I or more, or a ratio of NH4+ to Cu of about 4050:I or more; or the fermentation medium has a weight ratio of P to B of about 30:1 or more, or a weight ratio of P to Mn of about 190:1 or more, or a weight ratio of P to Mo of about 120:1 or more, or a weight ratio of Mn to Cu of about 190:1 or more; or the fermentation medium has a weight ratio of K to B of about 35:1 or more, or a weight ratio of K to Mn of about 245:1 or more, or a weight ratio of K to Mo of about 150:1 or more, or a weight ratio of K to Cu of about 245:1 or more.
Abstract translation: 发酵合成气和发酵培养基的方法提供高乙醇生产力，同时除去先前被认为是必需的培养基成分。 该方法对于提供至少约1g乙醇/（L-天 - 克细胞）的特异性STY是有效的。 在这方面，发酵培养基的NH4 +与B的重量比为约625:1或更高，或NH4 +与Mn的重量比为约4050:1或更高，或NH /与Mo的重量比约为 2500：1以上，NH 4 +与Cu的比例为约4050：1以上; 或发酵培养基中P与B的重量比为约30:1或更高，或P与Mn的重量比为约190:1或更高，或P与Mo的重量比为约120:1，或 更多，或Mn与Cu的重量比为约190：1以上; 或发酵培养基的K与B的重量比为约35:1或更高，或K与Mn的重量比为约245:1或更高，或K与Mo的重量比为约150:1或 更多，或K与Cu的重量比为约245:1或更高。
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公开(公告)号：US20130149693A1
公开(公告)日：2013-06-13
申请号：US13660518
申请日：2012-10-25
Applicant: INEOS BIO SA
Inventor： Ryan Senaratne , Song Liu
Abstract: A process is provided for management of ethanol concentration during syngas fermentation. A process for fermentation of syngas includes inoculating a medium to provide an inoculated medium. Inoculated medium is contacted with syngas and cells and medium are removed and separated to provide concentrated cells and permeate. Ethanol is separated from the permeate to provide ethanol and a reduced ethanol aqueous stream. The reduced ethanol aqueous stream is returned to the fermentation.
Abstract translation: 提供合成气发酵过程中乙醇浓度的管理。 合成气的发酵方法包括接种培养基以提供接种培养基。 接种的培养基与合成气接触，细胞和培养基被去除并分离以提供浓缩的细胞和渗透物。 将乙醇与渗透物分离以提供乙醇和还原的乙醇水流。 将还原的乙醇水流返回发酵。
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公开(公告)号：US08980575B2
公开(公告)日：2015-03-17
申请号：US14018487
申请日：2013-09-05
Applicant: Ineos Bio SA
Inventor： Ryan Senaratne
CPC classification number: C12Q1/04 , C12P7/065 , C12P7/08 , C12Q3/00 , G01N21/31 , G01N33/84 , Y02E50/17
Abstract: A process is provided for fermenting CO-containing gaseous substrates. The process is effective for decreasing lag times and maintaining a culture in steady state by controlling CO concentration and minimizing effects of high or low CO concentrations during fermentation. The process includes providing syngas to a first fermentation zone, fermenting the syngas, and determining a CO concentration in a fermentation medium in the first fermentation zone. If the CO concentration in fermentation medium in the first fermentation zone has a calculated value of about 0.12 mM or greater, then at least a portion of the syngas being provided to the first fermentation zone is provided to one or more subsequent fermentation zones in an amount effective for providing a calculated CO concentration in any subsequent fermentation zone of about 0.12 mM or less.
Abstract translation: 提供了一种用于发酵含CO气体底物的方法。 该方法通过控制CO浓度和最小化发酵过程中高浓度或低CO浓度的影响，有效减少滞后时间并保持培养状态。 该方法包括向第一发酵区提供合成气，发酵合成气，以及确定第一发酵区中发酵培养基中的CO浓度。 如果第一发酵区的发酵培养基中的CO浓度具有约0.12mM或更大的计算值，则将提供给第一发酵区的合成气的至少一部分提供给一个或多个后续的发酵区， 对于在约0.12mM或更少的任何后续发酵区域中提供计算的CO浓度是有效的。
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公开(公告)号：US20140080169A1
公开(公告)日：2014-03-20
申请号：US14018487
申请日：2013-09-05
Applicant: INEOS BIO SA
Inventor： Ryan Senaratne
IPC: C12P7/06
CPC classification number: C12Q1/04 , C12P7/065 , C12P7/08 , C12Q3/00 , G01N21/31 , G01N33/84 , Y02E50/17
Abstract: A process is provided for fermenting CO-containing gaseous substrates. The process is effective for decreasing lag times and maintaining a culture in steady state by controlling CO concentration and minimizing effects of high or low CO concentrations during fermentation. The process includes providing syngas to a first fermentation zone, fermenting the syngas, and determining a CO concentration in a fermentation medium in the first fermentation zone. If the CO concentration in fermentation medium in the first fermentation zone has a calculated value of about 0.12 mM or greater, then at least a portion of the syngas being provided to the first fermentation zone is provided to one or more subsequent fermentation zones in an amount effective for providing a calculated CO concentration in any subsequent fermentation zone of about 0.12 mM or less.
Abstract translation: 提供了一种用于发酵含CO气体底物的方法。 该方法通过控制CO浓度和最小化发酵过程中高浓度或低CO浓度的影响，有效减少滞后时间并保持培养状态。 该方法包括向第一发酵区提供合成气，发酵合成气，以及确定第一发酵区中发酵培养基中的CO浓度。 如果第一发酵区的发酵培养基中的CO浓度具有约0.12mM或更大的计算值，则将提供给第一发酵区的合成气的至少一部分提供给一个或多个后续的发酵区， 对于在约0.12mM或更少的任何后续发酵区域中提供计算的CO浓度是有效的。
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7.发明申请METHOD OF OPERATION OF FERMENTATION OF CARBON MONOXIDE CONTAINING GASEOUS SUBSTRATE 审中-公开含有一氧化碳气相底物的发酵方法公开(公告)号：US20130252277A1
公开(公告)日：2013-09-26
申请号：US13989111
申请日：2011-11-14
Applicant: INEOS BIO SA
Inventor： Ryan Senaratne , Brandon Beard
CPC classification number: C12P7/54 , C12M21/04 , C12M21/12 , C12M27/02 , C12M29/04 , C12M29/18 , C12P7/02 , C12P7/065 , C12P7/16 , Y02E50/17
Abstract: The present disclosure provides methods of gaseous substrate fermentation comprising: adding gaseous substrate into an aqueous medium in a bioreactor. The methods of the present disclosure comprise: measuring cell density; adjusting input of gaseous substrate to increase cell density; changing specific CO uptake in predetermined amounts.
Abstract translation: 本公开提供了气态底物发酵的方法，其包括：将气态底物添加到生物反应器中的水性介质中。 本公开的方法包括：测量细胞密度; 调整气态底物的输入以增加细胞密度; 改变预定量的特定CO吸收。
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