公开(公告)号：US20220089761A1

公开(公告)日：2022-03-24

申请号：US17288234

申请日：2019-10-30

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Pavel Andreevich IAKOVLEV ,  Natalia Eugenievna PESTOVA ,  Arina Vitalevna ANIKINA ,  Anna Alexandrovna TRUDOVISHNIKOVA ,  Mariia Aleksandrovna SHCHEMELEVA ,  Nina Grachyaevna KHARATIAN ,  Valery Vladimirovich SOLOVYEV ,  Alexey Konstantinovich MISORIN ,  Sergei Vasilyevich DIDUK ,  Anna Vladimirovna EROSHOVA ,  Veronika Sergeevna USATOVA ,  Elena Andreevna KRENDELEVA ,  Iakov Iurevich USTIUGOV ,  Aleksei Aleksandrovich ALEKSANDROV ,  Iana Andreevna SMIRNOVA ,  Svetlana Vladimirovna KOSKOVA ,  Roman Alekseevich IVANOV ,  Dmitry Valentinovich MOROZOV

IPC: C07K16/28 ,  A61P35/02 ,  C12N15/63

Abstract: The present invention relates to biotechnology and provides a monoclonal antibody that specifically binds to CD20. The invention also relates to DNA encoding said antibody, the corresponding expression vectors and methods of production thereof, as well as methods of treatment using said antibody.

公开(公告)号：US20210332120A1

公开(公告)日：2021-10-28

申请号：US16097562

申请日：2016-12-02

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Dmitry Valentinovich MOROZOV ,  Andrei Borisovich ULITIN ,  Ekaterina Sergeevna ZUBAREVA ,  Iakov Iurevich USTIUGOV ,  Aleksandr Vladimirovich KARABELSKII ,  Dmitry Valeryevich KORZHAVIN ,  Tatiana Veniaminovna CHERNOVSKAYA ,  Aleksandr Valerevich GRACHEV ,  Yury Ivanovich BASOVSKIY ,  Ekaterina Aleksandrovna LOMKOVA ,  Veronika Sergeevna USATOVA ,  Aleksei Aleksandrovich ALEKSANDROV ,  Elena Leonidovna MOROZOVA ,  Roman Alekseevich IVANOV ,  Pavel Andreevich IAKOVLEV

IPC: C07K16/24 ,  A61P19/02 ,  A61K45/06 ,  A61K39/395

Abstract: The present invention relates to the field of biotechnology and provides monoclonal tri-specific binding molecules that specifically bind to human IL-17A, human IL-17F, and a human pro-inflammatory molecule (in particular, TNFα) with high affinity. The invention also relates to DNA constructs encoding said binding molecules, related expression vectors and methods of production, and methods of treatment using said binding molecules.