公开(公告)号：US20220056133A1

公开(公告)日：2022-02-24

申请号：US17417570

申请日：2019-12-24

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Olga Vladimirovna BRITANOVA ,  Dmitry Borisovich STAROVEROV ,  Anna Valentinovna EVSTRATEVA ,  Alexey Konstantinovich MISORIN ,  Timofey Aleksandrovich NEMANKIN ,  Mariia Aleksandrovna SHCHEMELEVA ,  Anna Konstantinovna VLADIMIROVA ,  Arina Vitalevna ANIKINA ,  Roman Alekseevich IVANOV ,  Dmitry Valentinovich MOROZOV ,  Pavel Andreevich IAKOVLEV ,  Sergey Anatolievich LUKYANOV

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395

Abstract: The invention relates to a monoclonal humanized antibody or antigen-binding fragment thereof that specifically bind to the TRBV9 family of the human T cell receptor. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and use of said antibody in treatment of diseases or disorders associated with the human T cell receptor family. The invention is directed to generation of antibodies that can be used for treating, in particular AS, celiac disease and malignant blood diseases, the pathogenesis of which involves the TRBV9 family TCRs.

公开(公告)号：US20220112286A1

公开(公告)日：2022-04-14

申请号：US17417686

申请日：2020-02-20

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Olga Vladimirovna BRITANOVA ,  Dmitry Borisovich STAROVEROV ,  Anna Valentinovna EVSTRATEVA ,  Alexey Konstantinovich MISORIN ,  Timofey Aleksandrovich NEMANKIN ,  Mariia Aleksandrovna SHCHEMELEVA ,  Anna Konstantinovna VLADIMIROVA ,  Arina Vitalevna ANIKINA ,  Roman Alekseevich IVANOV ,  Dmitry Valentinovich MOROZOV ,  Pavel Andreevich IAKOVLEV ,  Sergey Anatolievich LUKYANOV

IPC: C07K16/28

Abstract: The invention relates to a monoclonal humanized antibody or antigen-binding fragment thereof that specifically bind to the TRBV9 family of the human T cell receptor. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and use of said antibody in treatment of diseases or disorders associated with the human T cell receptor family. The invention is directed to generation of antibodies that can be used for treating, in particular AS, celiac disease and malignant blood diseases, the pathogenesis of which involves the TRBV9 family TCRs.

公开(公告)号：US20220089761A1

公开(公告)日：2022-03-24

申请号：US17288234

申请日：2019-10-30

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Pavel Andreevich IAKOVLEV ,  Natalia Eugenievna PESTOVA ,  Arina Vitalevna ANIKINA ,  Anna Alexandrovna TRUDOVISHNIKOVA ,  Mariia Aleksandrovna SHCHEMELEVA ,  Nina Grachyaevna KHARATIAN ,  Valery Vladimirovich SOLOVYEV ,  Alexey Konstantinovich MISORIN ,  Sergei Vasilyevich DIDUK ,  Anna Vladimirovna EROSHOVA ,  Veronika Sergeevna USATOVA ,  Elena Andreevna KRENDELEVA ,  Iakov Iurevich USTIUGOV ,  Aleksei Aleksandrovich ALEKSANDROV ,  Iana Andreevna SMIRNOVA ,  Svetlana Vladimirovna KOSKOVA ,  Roman Alekseevich IVANOV ,  Dmitry Valentinovich MOROZOV

IPC: C07K16/28 ,  A61P35/02 ,  C12N15/63

Abstract: The present invention relates to biotechnology and provides a monoclonal antibody that specifically binds to CD20. The invention also relates to DNA encoding said antibody, the corresponding expression vectors and methods of production thereof, as well as methods of treatment using said antibody.