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![N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors](/abs-image/US/2014/05/06/US08716303B2/abs.jpg.150x150.jpg)
1.发明授权N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors 有权吡唑-4-基 - 吡咯并[2,3-d]嘧啶和吡咯-3-基 - 吡咯并[2,3-d]嘧啶的N-（杂）芳基 - 吡咯烷衍生物作为甘蔗激酶抑制剂公开(公告)号：US08716303B2
公开(公告)日：2014-05-06
申请号：US12784916
申请日：2010-05-21
申请人： James D. Rodgers , Stacey Shepard , Argyrios G. Arvanitis , Haisheng Wang , Louis Storace , Beverly Folmer , Lixin Shao , Wenyu Zhu , Joseph Glenn
发明人： James D. Rodgers , Stacey Shepard , Argyrios G. Arvanitis , Haisheng Wang , Louis Storace , Beverly Folmer , Lixin Shao , Wenyu Zhu , Joseph Glenn
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04 , C07D471/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula I: which are JAK inhibitors, such as selective JAK1 inhibitors, useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.
摘要翻译： 本发明涉及式I的N-（杂）芳基 - 吡咯烷衍生物：其是JAK抑制剂，例如选择性JAK1抑制剂，其可用于治疗JAK相关疾病，包括例如炎性和自身免疫性疾病，以及 作为癌症。
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![N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS](/abs-image/US/2010/11/25/US20100298334A1/abs.jpg.150x150.jpg)
2.发明申请N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS 有权作为丙酮激酶抑制剂的吡唑-4-基-L-吡咯烷[2,3-d]嘧啶和吡咯-3-基]吡咯[2,3-d]吡嗪的N-（异噻唑啉）吡咯烷衍生物公开(公告)号：US20100298334A1
公开(公告)日：2010-11-25
申请号：US12784916
申请日：2010-05-21
申请人： James D. Rodgers , Stacey Shepard , Argyrios G. Arvanitis , Haisheng Wang , Louis Storace , Beverly Folmer , Lixin Shao , Wenyu Zhu , Joseph Glenn
发明人： James D. Rodgers , Stacey Shepard , Argyrios G. Arvanitis , Haisheng Wang , Louis Storace , Beverly Folmer , Lixin Shao , Wenyu Zhu , Joseph Glenn
IPC分类号： A61K31/519 , C07D487/04 , C07D498/04 , A61P35/00 , A61P29/00 , A61P3/10 , A61P25/00 , A61P17/00 , A61P37/06 , C12N9/99
CPC分类号： C07D487/04 , C07D471/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula I: which are JAK inhibitors, such as selective JAK1 inhibitors, useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.
摘要翻译： 本发明涉及式I的N-（杂）芳基 - 吡咯烷衍生物：其是JAK抑制剂，例如选择性JAK1抑制剂，其可用于治疗JAK相关疾病，包括例如炎性和自身免疫性疾病，以及 作为癌症。
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![HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS](/abs-image/US/2011/09/15/US20110223210A1/abs.jpg.150x150.jpg)
公开(公告)号：US20110223210A1
公开(公告)日：2011-09-15
申请号：US13076220
申请日：2011-03-30
申请人： James D. Rodgers , Stacey Shepard , Thomas P. Maduskuie, JR. , Haisheng Wang , Nikoo Falahatpisheh , Maria Rafalski , Argyrios G. Arvanitis , Louis Storace , Ravikumar Jalluri , Jordan S. Fridman , Krishna Vaddi
发明人： James D. Rodgers , Stacey Shepard , Thomas P. Maduskuie, JR. , Haisheng Wang , Nikoo Falahatpisheh , Maria Rafalski , Argyrios G. Arvanitis , Louis Storace , Ravikumar Jalluri , Jordan S. Fridman , Krishna Vaddi
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0053 , A61K9/20 , A61K31/573 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
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![HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS](/abs-image/US/2010/01/28/US20100022522A1/abs.jpg.150x150.jpg)
4.发明申请HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS 有权异丙基取代的吡咯并[2,3-b]吡啶和吡咯并[2,3-b]吡嗪类作为甘薯激酶抑制剂公开(公告)号：US20100022522A1
公开(公告)日：2010-01-28
申请号：US12549170
申请日：2009-08-27
申请人： James D. Rodgers , Stacey Shepard , Thomas P. Maduskuie, JR. , Haisheng Wang , Nikoo Falahatpisheh , Maria Rafalski , Argyrios G. Arvanitis , Louis Storace , Ravikumar Jalluri , Jordan S. Fridman , Krishna Vaddi
发明人： James D. Rodgers , Stacey Shepard , Thomas P. Maduskuie, JR. , Haisheng Wang , Nikoo Falahatpisheh , Maria Rafalski , Argyrios G. Arvanitis , Louis Storace , Ravikumar Jalluri , Jordan S. Fridman , Krishna Vaddi
IPC分类号： A61K31/437 , C07D471/04 , C07D401/14 , C07D487/04 , C07D413/14 , C07D417/14 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/541 , A61P37/06 , A61P17/00 , A61P31/12 , A61P35/00 , A61P29/00
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0053 , A61K9/20 , A61K31/573 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
摘要翻译： 本发明提供调节Janus激酶活性的杂芳基取代的吡咯并[2,3-b]吡啶和杂芳基取代的吡咯并[2,3-b]嘧啶，可用于治疗与Janus激酶活性有关的疾病， 例如免疫相关疾病，皮肤病，骨髓增生性疾病，癌症和其它疾病。
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![Pyrazolyl substituted pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors](/abs-image/US/2013/04/09/US08415362B2/abs.jpg.150x150.jpg)
5.发明授权Pyrazolyl substituted pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors 有权吡唑基取代的吡咯并[2,3-b]嘧啶作为Janus激酶抑制剂公开(公告)号：US08415362B2
公开(公告)日：2013-04-09
申请号：US12138082
申请日：2008-06-12
申请人： James D. Rodgers , Stacey Shepard , Thomas P. Maduskuie , Haisheng Wang , Nikoo Falahatpisheh , Maria Rafalski , Argyrios G. Arvanitis , Louis Storace , Ravi Kumar Jalluri
发明人： James D. Rodgers , Stacey Shepard , Thomas P. Maduskuie , Haisheng Wang , Nikoo Falahatpisheh , Maria Rafalski , Argyrios G. Arvanitis , Louis Storace , Ravi Kumar Jalluri
IPC分类号： C07D487/04 , A61K31/519 , A61K31/437 , C07D471/04 , A61P35/00 , A61P29/00
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0053 , A61K9/20 , A61K31/573 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines of Formula I: that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
摘要翻译： 本发明提供式I的杂芳基取代的吡咯并[2,3-b]吡啶和杂芳基取代的吡咯并[2,3-b]嘧啶：其调节Janus激酶的活性，并且可用于治疗与 Janus激酶包括例如免疫相关疾病，皮肤病，骨髓增生性疾病，癌症和其它疾病。
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公开(公告)号：US20090215766A1
公开(公告)日：2009-08-27
申请号：US12187061
申请日：2008-08-06
申请人： James D. Rodgers , Darius J. Robinson , Argyrios G. Arvanitis , Thomas P. Maduskuie, JR. , Stacey Shepard , Louis Storace , Haisheng Wang , Maria Rafalski , Ravi Kumar Jalluri , Andrew P. Combs , Matthew L. Crawley
发明人： James D. Rodgers , Darius J. Robinson , Argyrios G. Arvanitis , Thomas P. Maduskuie, JR. , Stacey Shepard , Louis Storace , Haisheng Wang , Maria Rafalski , Ravi Kumar Jalluri , Andrew P. Combs , Matthew L. Crawley
IPC分类号： A61K31/5377 , C07D513/04 , A61K31/437 , C07D487/04 , A61P37/02 , C12N9/12 , A61P35/00 , A61P3/10 , C12N9/99 , A61K31/5025 , C07D417/14 , A61K31/496
CPC分类号： C07D471/22 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D498/04 , C07D498/14 , C07D513/04 , C07D513/14
摘要： The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.
摘要翻译： 本发明提供调节Janus激酶活性的化合物，并且可用于治疗与Janus激酶（例如免疫相关疾病和癌症）的活性相关的疾病。
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![HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS](/abs-image/US/2011/09/15/US20110224157A1/abs.jpg.150x150.jpg)
7.发明申请HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS 有权异丙基取代的吡咯并[2,3-b]吡啶和吡咯并[2,3-b]吡嗪类作为甘薯激酶抑制剂公开(公告)号：US20110224157A1
公开(公告)日：2011-09-15
申请号：US13076176
申请日：2011-03-30
申请人： James D. Rodgers , Stacey Shepard , Thomas P. Maduskuie, JR. , Haisheng Wang , Nikoo Falahatpisheh , Maria Rafalski , Argyrios G. Arvanitis , Louis Storace , Ravi Kumar Jalluri , Jordan S. Fridman , Krishna Vaddi
发明人： James D. Rodgers , Stacey Shepard , Thomas P. Maduskuie, JR. , Haisheng Wang , Nikoo Falahatpisheh , Maria Rafalski , Argyrios G. Arvanitis , Louis Storace , Ravi Kumar Jalluri , Jordan S. Fridman , Krishna Vaddi
IPC分类号： A61K31/519 , A61K31/704 , A61K31/675 , A61K31/7048 , A61K31/573 , A61K31/69 , A61P35/00 , A61P43/00 , A61P35/02 , A61P9/00
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0053 , A61K9/20 , A61K31/573 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
摘要翻译： 本发明提供调节Janus激酶活性的杂芳基取代的吡咯并[2,3-b]吡啶和杂芳基取代的吡咯并[2,3-b]嘧啶，可用于治疗与Janus激酶活性有关的疾病， 例如免疫相关疾病，皮肤病，骨髓增生性疾病，癌症和其它疾病。
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![HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS](/abs-image/US/2009/07/16/US20090181959A1/abs.jpg.150x150.jpg)
8.发明申请HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS 有权异丙基取代的吡咯并[2,3-b]吡啶和吡咯并[2,3-b]吡嗪类作为甘薯激酶抑制剂公开(公告)号：US20090181959A1
公开(公告)日：2009-07-16
申请号：US12138082
申请日：2008-06-12
申请人： James D. Rodgers , Stacey Shepard , Thomas P. Maduskuie, JR. , Haisheng Wang , Nikoo Falahatpisheh , Maria Rafalski , Argyrios G. Arvanitis , Louis Storace , Ravi Kumar Jalluri , Jordan S. Fridman , Krishna Vaddi
发明人： James D. Rodgers , Stacey Shepard , Thomas P. Maduskuie, JR. , Haisheng Wang , Nikoo Falahatpisheh , Maria Rafalski , Argyrios G. Arvanitis , Louis Storace , Ravi Kumar Jalluri , Jordan S. Fridman , Krishna Vaddi
IPC分类号： A61K31/519 , A61P37/06 , A61P17/00 , A61P31/12 , A61P29/00 , A61P11/00 , A61K31/437 , C07D471/04 , C07D487/04 , A61K31/541 , A61K31/5377 , A61K31/496
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0053 , A61K9/20 , A61K31/573 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
摘要翻译： 本发明提供调节Janus激酶活性的杂芳基取代的吡咯并[2,3-b]吡啶和杂芳基取代的吡咯并[2,3-b]嘧啶，并且可用于治疗与Janus激酶活性有关的疾病， 例如免疫相关疾病，皮肤病，骨髓增生性疾病，癌症和其它疾病。
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公开(公告)号：US08513270B2
公开(公告)日：2013-08-20
申请号：US11961424
申请日：2007-12-20
IPC分类号： A01N43/54 , A61K31/505 , C07D491/00 , C07D239/00 , C07D471/00 , C07D487/00
CPC分类号： C07D487/14 , A61K31/437 , C07D471/14 , C07D487/04
摘要： The present invention provides substituted tricyclic heteroaryl compounds, including, for example, pyridoindoles, pyrimidinoindoles and triazinoindoles that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases such as immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
摘要翻译： 本发明提供取代的三环杂芳基化合物，包括例如吡啶并吲哚，嘧啶并吲哚和三嗪基吲哚，其调节Janus激酶的活性，并且可用于治疗与Janus激酶的活性有关的疾病，例如免疫相关疾病，皮肤病， 骨髓增生性疾病，癌症等疾病。
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公开(公告)号：US20080188500A1
公开(公告)日：2008-08-07
申请号：US11961424
申请日：2007-12-20
IPC分类号： A61K31/4985 , C07D471/04 , C07D471/14 , A61P37/06 , A61P11/06 , A61P35/00
CPC分类号： C07D487/14 , A61K31/437 , C07D471/14 , C07D487/04
摘要： The present invention provides substituted tricyclic heteroaryl compounds, including, for example, pyridoindoles, pyrimidinoindoles and triazinoindoles that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases such as immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
摘要翻译： 本发明提供取代的三环杂芳基化合物，包括例如吡啶并吲哚，嘧啶并吲哚和三嗪基吲哚，其调节Janus激酶的活性，并且可用于治疗与Janus激酶的活性有关的疾病，例如免疫相关疾病，皮肤病， 骨髓增生性疾病，癌症等疾病。
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