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![HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS](/abs-image/US/2011/09/15/US20110223210A1/abs.jpg.150x150.jpg)
公开(公告)号：US20110223210A1
公开(公告)日：2011-09-15
申请号：US13076220
申请日：2011-03-30
申请人： James D. Rodgers , Stacey Shepard , Thomas P. Maduskuie, JR. , Haisheng Wang , Nikoo Falahatpisheh , Maria Rafalski , Argyrios G. Arvanitis , Louis Storace , Ravikumar Jalluri , Jordan S. Fridman , Krishna Vaddi
发明人： James D. Rodgers , Stacey Shepard , Thomas P. Maduskuie, JR. , Haisheng Wang , Nikoo Falahatpisheh , Maria Rafalski , Argyrios G. Arvanitis , Louis Storace , Ravikumar Jalluri , Jordan S. Fridman , Krishna Vaddi
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0053 , A61K9/20 , A61K31/573 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
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![HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS](/abs-image/US/2010/01/28/US20100022522A1/abs.jpg.150x150.jpg)
2.发明申请HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS 有权异丙基取代的吡咯并[2,3-b]吡啶和吡咯并[2,3-b]吡嗪类作为甘薯激酶抑制剂公开(公告)号：US20100022522A1
公开(公告)日：2010-01-28
申请号：US12549170
申请日：2009-08-27
申请人： James D. Rodgers , Stacey Shepard , Thomas P. Maduskuie, JR. , Haisheng Wang , Nikoo Falahatpisheh , Maria Rafalski , Argyrios G. Arvanitis , Louis Storace , Ravikumar Jalluri , Jordan S. Fridman , Krishna Vaddi
发明人： James D. Rodgers , Stacey Shepard , Thomas P. Maduskuie, JR. , Haisheng Wang , Nikoo Falahatpisheh , Maria Rafalski , Argyrios G. Arvanitis , Louis Storace , Ravikumar Jalluri , Jordan S. Fridman , Krishna Vaddi
IPC分类号： A61K31/437 , C07D471/04 , C07D401/14 , C07D487/04 , C07D413/14 , C07D417/14 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/541 , A61P37/06 , A61P17/00 , A61P31/12 , A61P35/00 , A61P29/00
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0053 , A61K9/20 , A61K31/573 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
摘要翻译： 本发明提供调节Janus激酶活性的杂芳基取代的吡咯并[2,3-b]吡啶和杂芳基取代的吡咯并[2,3-b]嘧啶，可用于治疗与Janus激酶活性有关的疾病， 例如免疫相关疾病，皮肤病，骨髓增生性疾病，癌症和其它疾病。
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![HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS](/abs-image/US/2011/09/15/US20110224157A1/abs.jpg.150x150.jpg)
3.发明申请HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS 有权异丙基取代的吡咯并[2,3-b]吡啶和吡咯并[2,3-b]吡嗪类作为甘薯激酶抑制剂公开(公告)号：US20110224157A1
公开(公告)日：2011-09-15
申请号：US13076176
申请日：2011-03-30
申请人： James D. Rodgers , Stacey Shepard , Thomas P. Maduskuie, JR. , Haisheng Wang , Nikoo Falahatpisheh , Maria Rafalski , Argyrios G. Arvanitis , Louis Storace , Ravi Kumar Jalluri , Jordan S. Fridman , Krishna Vaddi
发明人： James D. Rodgers , Stacey Shepard , Thomas P. Maduskuie, JR. , Haisheng Wang , Nikoo Falahatpisheh , Maria Rafalski , Argyrios G. Arvanitis , Louis Storace , Ravi Kumar Jalluri , Jordan S. Fridman , Krishna Vaddi
IPC分类号： A61K31/519 , A61K31/704 , A61K31/675 , A61K31/7048 , A61K31/573 , A61K31/69 , A61P35/00 , A61P43/00 , A61P35/02 , A61P9/00
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0053 , A61K9/20 , A61K31/573 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
摘要翻译： 本发明提供调节Janus激酶活性的杂芳基取代的吡咯并[2,3-b]吡啶和杂芳基取代的吡咯并[2,3-b]嘧啶，可用于治疗与Janus激酶活性有关的疾病， 例如免疫相关疾病，皮肤病，骨髓增生性疾病，癌症和其它疾病。
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![HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS](/abs-image/US/2009/07/16/US20090181959A1/abs.jpg.150x150.jpg)
4.发明申请HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS 有权异丙基取代的吡咯并[2,3-b]吡啶和吡咯并[2,3-b]吡嗪类作为甘薯激酶抑制剂公开(公告)号：US20090181959A1
公开(公告)日：2009-07-16
申请号：US12138082
申请日：2008-06-12
申请人： James D. Rodgers , Stacey Shepard , Thomas P. Maduskuie, JR. , Haisheng Wang , Nikoo Falahatpisheh , Maria Rafalski , Argyrios G. Arvanitis , Louis Storace , Ravi Kumar Jalluri , Jordan S. Fridman , Krishna Vaddi
发明人： James D. Rodgers , Stacey Shepard , Thomas P. Maduskuie, JR. , Haisheng Wang , Nikoo Falahatpisheh , Maria Rafalski , Argyrios G. Arvanitis , Louis Storace , Ravi Kumar Jalluri , Jordan S. Fridman , Krishna Vaddi
IPC分类号： A61K31/519 , A61P37/06 , A61P17/00 , A61P31/12 , A61P29/00 , A61P11/00 , A61K31/437 , C07D471/04 , C07D487/04 , A61K31/541 , A61K31/5377 , A61K31/496
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0053 , A61K9/20 , A61K31/573 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
摘要翻译： 本发明提供调节Janus激酶活性的杂芳基取代的吡咯并[2,3-b]吡啶和杂芳基取代的吡咯并[2,3-b]嘧啶，并且可用于治疗与Janus激酶活性有关的疾病， 例如免疫相关疾病，皮肤病，骨髓增生性疾病，癌症和其它疾病。
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![Pyrazolyl substituted pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors](/abs-image/US/2013/04/09/US08415362B2/abs.jpg.150x150.jpg)
5.发明授权Pyrazolyl substituted pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors 有权吡唑基取代的吡咯并[2,3-b]嘧啶作为Janus激酶抑制剂公开(公告)号：US08415362B2
公开(公告)日：2013-04-09
申请号：US12138082
申请日：2008-06-12
申请人： James D. Rodgers , Stacey Shepard , Thomas P. Maduskuie , Haisheng Wang , Nikoo Falahatpisheh , Maria Rafalski , Argyrios G. Arvanitis , Louis Storace , Ravi Kumar Jalluri
发明人： James D. Rodgers , Stacey Shepard , Thomas P. Maduskuie , Haisheng Wang , Nikoo Falahatpisheh , Maria Rafalski , Argyrios G. Arvanitis , Louis Storace , Ravi Kumar Jalluri
IPC分类号： C07D487/04 , A61K31/519 , A61K31/437 , C07D471/04 , A61P35/00 , A61P29/00
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0053 , A61K9/20 , A61K31/573 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines of Formula I: that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
摘要翻译： 本发明提供式I的杂芳基取代的吡咯并[2,3-b]吡啶和杂芳基取代的吡咯并[2,3-b]嘧啶：其调节Janus激酶的活性，并且可用于治疗与 Janus激酶包括例如免疫相关疾病，皮肤病，骨髓增生性疾病，癌症和其它疾病。
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公开(公告)号：US20090215766A1
公开(公告)日：2009-08-27
申请号：US12187061
申请日：2008-08-06
申请人： James D. Rodgers , Darius J. Robinson , Argyrios G. Arvanitis , Thomas P. Maduskuie, JR. , Stacey Shepard , Louis Storace , Haisheng Wang , Maria Rafalski , Ravi Kumar Jalluri , Andrew P. Combs , Matthew L. Crawley
发明人： James D. Rodgers , Darius J. Robinson , Argyrios G. Arvanitis , Thomas P. Maduskuie, JR. , Stacey Shepard , Louis Storace , Haisheng Wang , Maria Rafalski , Ravi Kumar Jalluri , Andrew P. Combs , Matthew L. Crawley
IPC分类号： A61K31/5377 , C07D513/04 , A61K31/437 , C07D487/04 , A61P37/02 , C12N9/12 , A61P35/00 , A61P3/10 , C12N9/99 , A61K31/5025 , C07D417/14 , A61K31/496
CPC分类号： C07D471/22 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D498/04 , C07D498/14 , C07D513/04 , C07D513/14
摘要： The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.
摘要翻译： 本发明提供调节Janus激酶活性的化合物，并且可用于治疗与Janus激酶（例如免疫相关疾病和癌症）的活性相关的疾病。
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![Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors](/abs-image/US/2007/06/14/US20070135461A1/abs.jpg.150x150.jpg)
7.发明申请Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors 有权杂芳基取代的吡咯并[2,3-b]吡啶和吡咯并[2,3-b]公开(公告)号：US20070135461A1
公开(公告)日：2007-06-14
申请号：US11637545
申请日：2006-12-12
申请人： James Rodgers , Stacey Shepard , Thomas Maduskuie , Haisheng Wang , Nikoo Falahatpisheh , Maria Rafalski , Argyrios Arvanitis , Louis Storace , Ravi Jalluri , Jordan Fridman , Krishna Vaddi
发明人： James Rodgers , Stacey Shepard , Thomas Maduskuie , Haisheng Wang , Nikoo Falahatpisheh , Maria Rafalski , Argyrios Arvanitis , Louis Storace , Ravi Jalluri , Jordan Fridman , Krishna Vaddi
IPC分类号： A61K31/519 , A61K31/4745 , C07D487/02 , C07D471/02
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0053 , A61K9/20 , A61K31/573 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
摘要翻译： 本发明提供调节Janus激酶活性的杂芳基取代的吡咯并[2,3-b]吡啶和杂芳基取代的吡咯并[2,3-b]嘧啶，可用于治疗与Janus激酶活性有关的疾病， 例如免疫相关疾病，皮肤病，骨髓增生性疾病，癌症和其它疾病。
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![N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors](/abs-image/US/2014/05/06/US08716303B2/abs.jpg.150x150.jpg)
8.发明授权N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors 有权吡唑-4-基 - 吡咯并[2,3-d]嘧啶和吡咯-3-基 - 吡咯并[2,3-d]嘧啶的N-（杂）芳基 - 吡咯烷衍生物作为甘蔗激酶抑制剂公开(公告)号：US08716303B2
公开(公告)日：2014-05-06
申请号：US12784916
申请日：2010-05-21
申请人： James D. Rodgers , Stacey Shepard , Argyrios G. Arvanitis , Haisheng Wang , Louis Storace , Beverly Folmer , Lixin Shao , Wenyu Zhu , Joseph Glenn
发明人： James D. Rodgers , Stacey Shepard , Argyrios G. Arvanitis , Haisheng Wang , Louis Storace , Beverly Folmer , Lixin Shao , Wenyu Zhu , Joseph Glenn
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04 , C07D471/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula I: which are JAK inhibitors, such as selective JAK1 inhibitors, useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.
摘要翻译： 本发明涉及式I的N-（杂）芳基 - 吡咯烷衍生物：其是JAK抑制剂，例如选择性JAK1抑制剂，其可用于治疗JAK相关疾病，包括例如炎性和自身免疫性疾病，以及 作为癌症。
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![N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS](/abs-image/US/2010/11/25/US20100298334A1/abs.jpg.150x150.jpg)
9.发明申请N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS 有权作为丙酮激酶抑制剂的吡唑-4-基-L-吡咯烷[2,3-d]嘧啶和吡咯-3-基]吡咯[2,3-d]吡嗪的N-（异噻唑啉）吡咯烷衍生物公开(公告)号：US20100298334A1
公开(公告)日：2010-11-25
申请号：US12784916
申请日：2010-05-21
申请人： James D. Rodgers , Stacey Shepard , Argyrios G. Arvanitis , Haisheng Wang , Louis Storace , Beverly Folmer , Lixin Shao , Wenyu Zhu , Joseph Glenn
发明人： James D. Rodgers , Stacey Shepard , Argyrios G. Arvanitis , Haisheng Wang , Louis Storace , Beverly Folmer , Lixin Shao , Wenyu Zhu , Joseph Glenn
IPC分类号： A61K31/519 , C07D487/04 , C07D498/04 , A61P35/00 , A61P29/00 , A61P3/10 , A61P25/00 , A61P17/00 , A61P37/06 , C12N9/99
CPC分类号： C07D487/04 , C07D471/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula I: which are JAK inhibitors, such as selective JAK1 inhibitors, useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.
摘要翻译： 本发明涉及式I的N-（杂）芳基 - 吡咯烷衍生物：其是JAK抑制剂，例如选择性JAK1抑制剂，其可用于治疗JAK相关疾病，包括例如炎性和自身免疫性疾病，以及 作为癌症。
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公开(公告)号：US20060106020A1
公开(公告)日：2006-05-18
申请号：US11115702
申请日：2005-04-27
申请人： James Rodgers , Darius Robinson , Argrios Arvanitis , Thomas Maduskuie , Stacey Shepard , Louis Storace , Haisheng Wang , Maria Rafalski , Ravi Jalluri , Andrew Combs , Matthew Crawley
发明人： James Rodgers , Darius Robinson , Argrios Arvanitis , Thomas Maduskuie , Stacey Shepard , Louis Storace , Haisheng Wang , Maria Rafalski , Ravi Jalluri , Andrew Combs , Matthew Crawley
IPC分类号： A61K31/503 , A61K31/519 , C07D487/14
CPC分类号： C07D471/22 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D498/04 , C07D498/14 , C07D513/04 , C07D513/14
摘要： The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.
摘要翻译： 本发明提供调节Janus激酶活性的化合物，并且可用于治疗与Janus激酶（例如免疫相关疾病和癌症）的活性相关的疾病。
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