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1.发明授权公开(公告)号：US08417337B2
公开(公告)日：2013-04-09
申请号：US12501691
申请日：2009-07-13
申请人： James W. Busacker , Todd J. Sheldon
发明人： James W. Busacker , Todd J. Sheldon
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/371
摘要： In bi-ventricular pacing devices (including CRT devices) analysis of myocardial electrogram signals in one ventricle (e.g., a left ventricle, or “LV”) can be used to infer capture or loss-of-capture (LOC) of an earlier stimulus pulse in the same ventricle, on a continuous (every pacing cycle), triggered, aperiodic and/or periodic basis. Rather than using an evoked-response principle as has been the basis of capture detection in prior art and other systems, a principle employed via the present invention uses evidence of inter-ventricular conduction (i.e., from the opposite chamber) and/or atrio-ventricular conduction as evidence of LOC, since a non-capturing pacing stimulus provided to a first chamber will allow the myocardial tissue of the first chamber to remain non-refractory and thus inter-ventricular and atrio-ventricular wavefront propagation and conduction can commence and be detected thereby revealing whether LOC has occurred.
摘要翻译： 在双心室起搏装置（包括CRT装置）中，可以使用一个心室（例如左心室或左心室）心肌电图信号的分析来推断早期刺激脉冲的捕获或丢失（LOC） 相同的心室，连续（每个起搏周期），触发，非周期性和/或周期性基础。 而不是使用诱发反应原理作为现有技术和其他系统中的捕获检测的基础，通过本发明采用的原理使用心室间传导（即，从相对的室）和/或心室传导的证据， 心室传导作为LOC的证据，因为提供给第一腔室的非捕获起搏刺激将允许第一腔室的心肌组织保持不耐受，因此可以开始心室间壁和心房内波前传播和传导 检测出来是否显示LOC是否发生。
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2.发明授权公开(公告)号：US07561914B2
公开(公告)日：2009-07-14
申请号：US11312102
申请日：2005-12-20
申请人： James W. Busacker , Todd J. Sheldon
发明人： James W. Busacker , Todd J. Sheldon
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/371
摘要： In bi-ventricular pacing devices (including CRT devices) analysis of myocardial electrogram signals in one ventricle (e.g., a left ventricle, or “LV”) can be used to infer capture or loss-of-capture (LOC) of an earlier stimulus pulse in the same ventricle, on a continuous (every pacing cycle), triggered, aperiodic and/or periodic basis. Rather than using an evoked-response principle as has been the basis of capture detection in prior art and other systems, a principle employed via the present invention uses evidence of inter-ventricular conduction (i.e., from the opposite chamber) and/or atrio-ventricular conduction as evidence of LOC, since a non-capturing pacing stimulus provided to a first chamber will allow the myocardial tissue of the first chamber to remain non-refractory and thus inter-ventricular and atrio-ventricular wavefront propagation and conduction can commence and be detected thereby revealing whether LOC has occurred.
摘要翻译： 在双心室起搏装置（包括CRT装置）中，可以使用一个心室（例如，左心室或“LV”）的心肌电图信号分析来推断早期刺激的捕获或丢失（LOC） 脉冲在相同的心室，连续（每个起搏周期），触发，非周期和/或周期基础。 而不是使用诱发反应原理作为现有技术和其他系统中的捕获检测的基础，通过本发明采用的原理使用心室间传导（即，从相对的室）和/或心室传导的证据， 心室传导作为LOC的证据，因为提供给第一腔室的非捕获起搏刺激将允许第一腔室的心肌组织保持不耐受，因此可以开始心室间和心室内波前传播和传导 检测出来是否显示LOC是否发生。
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公开(公告)号：US07280868B2
公开(公告)日：2007-10-09
申请号：US10434689
申请日：2003-05-09
IPC分类号： A61N1/362
CPC分类号： A61N1/368 , A61N1/371 , A61N1/3712 , A61N1/3714 , A61N2001/083
摘要： A capture detection algorithm detects and distinguishes atrial capture. Atrial chamber reset (ACR) and AV conduction (AVC) algorithms are implemented to measure an atrial pacing threshold The data that is used to choose between ACR and AVC methods is used to determine the progression of the patient's disease state. Some of the significant aspects of the invention include enablement of accurate threshold measurements, including calculation of stability criteria, precise interval measurements and the use of reference interval to determine capture and loss of capture.
摘要翻译： 捕获检测算法检测并区分心房捕获。 实施房室复位（ACR）和AV传导（AVC）算法来测量心房起搏阈值用于在ACR和AVC方法之间选择的数据用于确定患者疾病状态的进展。 本发明的一些重要方面包括启用准确的阈值测量，包括稳定性标准的计算，精确的间隔测量以及参考间隔的使用以确定捕获和捕获的丢失。
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4.发明申请公开(公告)号：US20090276001A1
公开(公告)日：2009-11-05
申请号：US12501691
申请日：2009-07-13
申请人： James W. Busacker , Todd J. Sheldon
发明人： James W. Busacker , Todd J. Sheldon
IPC分类号： A61N1/37
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/371
摘要： In bi-ventricular pacing devices (including CRT devices) analysis of myocardial electrogram signals in one ventricle (e.g., a left ventricle, or “LV”) can same ventricle, on a continuous (every pacing cycle), triggered, aperiodic and/or periodic basis. Rather than using an evoked-response principle as has been the basis of capture detection in prior art and other systems, a principle employed via the present invention uses evidence of inter-ventricular conduction (i.e., from the opposite chamber) and/or atrio-ventricular conduction as evidence of LOC, since a non-capturing pacing stimulus provided to a first chamber will allow the myocardial tissue of the first chamber to remain non-refractory and thus inter-ventricular and atrio-ventricular wavefront propagation and conduction can commence and be detected thereby revealing whether LOC has occurred.
摘要翻译： 在双心室起搏装置（包括CRT装置）中，在一个心室（例如，左心室或“LV”）的心肌电图信号的分析可以在连续的（每个起搏周期）上相同的心室触发，非周期性和/或 定期的基础。 而不是使用诱发反应原理作为现有技术和其他系统中的捕获检测的基础，通过本发明采用的原理使用心室间传导（即，从相对的室）和/或心室传导的证据， 心室传导作为LOC的证据，因为提供给第一腔室的非捕获起搏刺激将允许第一腔室的心肌组织保持不耐受，因此可以开始心室间和心室内波前传播和传导 检测出来是否显示LOC是否发生。
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公开(公告)号：US10252062B2
公开(公告)日：2019-04-09
申请号：US11538711
申请日：2006-10-04
摘要： A system and method is provided for reliably indicating that an implantable medical device is in need of replacement. An implantable medical device includes a battery and a replacement indicator timer. The battery provides power to the implantable medical device. The replacement indicator timer counts a replacement time period to a determined replacement date for the implantable medical device. The replacement indicator timer starts the counting when an operational characteristic of the battery reaches a selected value.
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公开(公告)号：US6016448A
公开(公告)日：2000-01-18
申请号：US179619
申请日：1998-10-27
申请人： James W. Busacker , Can Cinbis
发明人： James W. Busacker , Can Cinbis
CPC分类号： A61N1/3708 , A61N1/3688
摘要： An automatic, body-implantable medical device having at least two modes of operation is disclosed. The device is provided with circuitry for automatically detecting when the device has been implanted in a patient, so that the device can automatically switch from a first mode to a second mode of operation upon implantation. In one embodiment, the first mode is a power conserving mode in which one or more non-essential sub-systems of the device are disabled. Prior to detection of implant, at least two conditions of the device known to reflect whether the device has been implanted are monitored. After implant has been detected, situations in which power to the device is disrupted and then restored will cause the device to enter a predefined "power-on-reset" mode of operation. Prior to detection of implant, however, such conditions do not result in the device entering the power-on-reset mode, or this mode is reset. An Elective Replacement Indicator mode is also used which is based on measured impedance against a target battery impedance. When the measured battery impedance reaches the target level, the voltage of the battery that precipitates an ERI condition is modified.
摘要翻译： 公开了具有至少两种操作模式的自动植入式医疗装置。 该装置设置有用于自动检测装置何时植入患者的电路，使得装置可以在植入时自动地从第一模式切换到第二模式。 在一个实施例中，第一模式是功率节省模式，其中该设备的一个或多个非必要子系统被禁用。 在检测植入物之前，监测已知反映装置是否植入的装置的至少两个条件。 在检测到植入物之后，设备电源中断然后恢复的情况将导致设备进入预定义的“上电复位”操作模式。 然而，在检测到植入物之前，这种条件不会导致器件进入上电复位模式，或者该模式被复位。 还使用选择性替换指示器模式，其基于针对目标电池阻抗的测量阻抗。 当测得的电池阻抗达到目标水平时，会改变引起ERI条件的电池电压。
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7.发明授权Adaptive search AV and auto PVARP adaptation to same with additional benefit 失效自适应搜索AV和自动PVARP适应相同，具有额外的好处
公开(公告)号：US5861007A
公开(公告)日：1999-01-19
申请号：US806302
申请日：1997-02-26
CPC分类号： A61N1/3627 , A61N1/3682
摘要： An AV search method and apparatus is taught with some variation described. It allows a pacemaker to find the appropriate AV interval so as to avoid pacing in the ventricle when it is not necessary, even if there is intermittent AV conduction in the patient. Also, an adaptive PVARP method and apparatus is disclosed that allows the PVARP and AV interval to be adjusted together automatically.
摘要翻译： 教导具有一些变化的AV搜索方法和装置。 它允许起搏器找到适当的AV间隔，以避免在不必要的情况下在心室起搏，即使在患者中存在间歇性AV传导。 此外，公开了一种自适应PVARP方法和装置，其允许PVARP和AV间隔自动调整。
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公开(公告)号：US5350411A
公开(公告)日：1994-09-27
申请号：US85489
申请日：1993-06-28
CPC分类号： A61N1/37252 , A61N1/3727 , H04L25/4902
摘要： An implantable medical device telemetry system provides a means for decoding telemetry downlink information transmitted from an external unit to an implanted medical device, and for encoding telemetry uplink signals to be transmitted from the implanted device to the external unit. A novel system architecture results in a very small telemetry subsystem in the implanted device and a very flexible system adaptable to be used in conjunction with various telemetry formats of various implanted devices. A programmable logic array (PLA) structure that is mask programmable and which may further be partially RAM programmable serves as the basis of the telemetry subsystem. For downlink telemetry, a counter is enabled during intervals of interest in the downlink RF burst stream. The counter value at the end of such an interval is then applied to the variable inputs of the PLA tier decoding in accordance with a selected telemetry protocol. For uplink telemetry, the counter and PLA is used to control transmission of uplink telemetry pulses, such that pulses are pulse-position modulated in accordance with data to be transmitted. Various different telemetry protocols may be supported by the same telemetry circuit, which may be mask-programmed at the time of manufacture to be compatible with one or more different telemetry protocols.
摘要翻译： 可植入医疗装置遥测系统提供了一种用于将从外部单元发送到植入医疗装置的遥测下行链路信息进行解码的装置，以及将要从植入装置发送到外部单元的遥测上行链路信号进行编码的装置。 一种新颖的系统架构在植入的装置中产生了非常小的遥测子系统，并且该灵活的系统适用于与各种植入装置的各种遥测方式结合使用。 可编程逻辑阵列（PLA）结构，其是掩模可编程的，并且可以进一步部分地可编程RAM用作遥测子系统的基础。 对于下行链路遥测，在下行链路RF突发流中感兴趣的间隔期间使能计数器。 然后根据所选择的遥测协议将这样的间隔结束时的计数器值应用于PLA层解码的可变输入。 对于上行链路遥测，计数器和PLA用于控制上行链路遥测脉冲的传输，使得脉冲根据要发送的数据进行脉冲位置调制。 各种不同的遥测协议可以由相同的遥测电路支持，该遥测电路可以在制造时被掩码编程以与一个或多个不同的遥测协议兼容。
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公开(公告)号：US07123964B2
公开(公告)日：2006-10-17
申请号：US10367316
申请日：2003-02-15
IPC分类号： A61N1/37
CPC分类号： A61N1/3708
摘要： A system and method is provided for reliably indicating that an implantable medical device is in need of replacement. The system and method measures the operational characteristics of the battery and the operational parameters of the implantable device itself. When these characteristics and parameters reach a defined level, the implantable medical device starts a replacement indicator timer. The replacement indicator timer starts and counts a replacement time period, with the replacement time period ending at a determined replacement date. The determined replacement date is the date at which the implantable medical device should be replaced.
摘要翻译： 提供了可靠地指示可植入医疗装置需要更换的系统和方法。 该系统和方法测量电池的操作特性和可植入装置本身的操作参数。 当这些特性和参数达到限定水平时，可植入医疗设备启动替换指示器定时器。 更换指示器定时器启动并计算更换时间段，替换时间段以确定的更换日期结束。 确定的更换日期是可更换植入式医疗设备的日期。
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10.发明授权
公开(公告)号：US6154675A
公开(公告)日：2000-11-28
申请号：US179773
申请日：1998-10-27
申请人： Carleen J. Juran , James W. Busacker , Michael B. Shelton , Charles R. Brynelsen , Thomas P. Edery , John D. Wahlstrand
发明人： Carleen J. Juran , James W. Busacker , Michael B. Shelton , Charles R. Brynelsen , Thomas P. Edery , John D. Wahlstrand
CPC分类号： A61N1/3708
摘要： An automatic, body-implantable medical device having at least two modes of operation is disclosed. The device is provided with circuitry for automatically detecting when the device has been implanted in a patient, so that the device can automatically switch from a first mode to a second mode of operation upon implantation. In one embodiment, the first mode is a power conserving mode in which one or more non-essential sub-systems of the device are disabled. Prior to detection of implant, at least two conditions of the device known to reflect whether the device has been implanted are monitored. After implant has been detected, situations in which power to the device is disrupted and then restored will cause the device to enter a predefined "power-on-reset" mode of operation. Prior to detection of implant, however, such conditions do not result in the device entering the power-on-reset mode, or this mode is reset. An Elective Replacement Indicator mode is also used which is based on measured impedance against a target battery impedance. When the measured battery impedance reaches the target level, the voltage of the battery that precipitates an ERI condition is modified.
摘要翻译： 公开了具有至少两种操作模式的自动植入式医疗装置。 该装置设置有用于自动检测装置何时植入患者的电路，使得装置可以在植入时自动地从第一模式切换到第二模式。 在一个实施例中，第一模式是功率节省模式，其中该设备的一个或多个非必要子系统被禁用。 在检测植入物之前，监测已知反映装置是否植入的装置的至少两个条件。 在检测到植入物之后，设备电源中断然后恢复的情况将导致设备进入预定义的“上电复位”操作模式。 然而，在检测到植入物之前，这种条件不会导致器件进入上电复位模式，或者该模式被复位。 还使用选择性替换指示器模式，其基于针对目标电池阻抗的测量阻抗。 当测得的电池阻抗达到目标水平时，会改变引起ERI条件的电池电压。
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