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    Methods and compositions using immunomodulatory compounds for the treatment and management of central nervous system disorders or diseases
    1.
    发明申请
    Methods and compositions using immunomodulatory compounds for the treatment and management of central nervous system disorders or diseases 审中-公开
    使用免疫调节化合物治疗和治疗中枢神经系统疾病或疾病的方法和组合物

    公开(公告)号：US20080227816A1

    公开(公告)日：2008-09-18

    申请号：US12154575

    申请日：2008-05-23

    申请人： Jerome B. Zeldis ,  Herbert Faleck ,  Peter H. Schafer

    发明人： Jerome B. Zeldis ,  Herbert Faleck ,  Peter H. Schafer

    IPC分类号： A61K31/445 ,  A61P25/16 ,  A61P29/00

    CPC分类号： A61K31/454 ,  A61K31/00

    摘要： Methods of treating, preventing and/or managing central nervous system disorders, such as Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease) and related syndromes are disclosed. Specific methods encompass the administration of an immunomodulatory compound of the invention, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active ingredient. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

    摘要翻译： 公开了治疗，预防和/或控制中枢神经系统疾病如肌萎缩性侧索硬化症（ALS或Lou Gehrig's disease）及相关综合征的方法。 具体方法包括单独或与第二活性成分组合施用本发明的免疫调节化合物或其药学上可接受的盐，溶剂合物，水合物，立体异构体，包合物或前药。 还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。

    Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate
    2.
    发明授权
    Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate 失效
    用D-threo哌甲酯治疗认知和绝经障碍的方法

    公开(公告)号：US06486177B2

    公开(公告)日：2002-11-26

    申请号：US09903803

    申请日：2001-07-12

    申请人： Jerome B. Zeldis ,  Herbert Faleck ,  Vikram Khetani

    发明人： Jerome B. Zeldis ,  Herbert Faleck ,  Vikram Khetani

    IPC分类号： A61K31445

    CPC分类号： C07D211/34 ,  A61K31/4458 ,  A61K45/06 ,  C12P17/12 ,  C12P41/006 ,  A61K2300/00

    摘要： In one aspect, the present invention is directed to methods for treating fatigue, neurobehavioral slowing and other cognitive disorders and defects due to cancers and treatments associated with cancers, and similar conditions. In a further aspect, the present invention is directed to methods for treating disorders related to menopause, including executive function defects. The methods involve the administration of a composition comprising D-threo methylphenidate that is substantially free of L-threo methylphenidate and of erythro forms of methylphenidate.

    摘要翻译： 一方面，本发明涉及用于治疗疲劳，神经行为减缓以及由于与癌症相关的癌症和治疗以及类似病症引起的其他认知障碍和缺陷的方法。 在另一方面，本发明涉及治疗与绝经相关的疾病的方法，包括执行功能缺陷。 所述方法包括施用包含基本上不含L-苏雷哌甲酯的D-苏雷哌甲酯和红皮质哌甲酯的组合物。

    Methods Of Diminishing Co-Abuse Potential
    4.
    发明申请
    Methods Of Diminishing Co-Abuse Potential 审中-公开
    减少共同滥用潜力的方法

    公开(公告)号：US20130158073A1

    公开(公告)日：2013-06-20

    申请号：US13765994

    申请日：2013-02-13

    申请人： Vikram Khetani ,  Herbert Faleck

    发明人： Vikram Khetani ,  Herbert Faleck

    IPC分类号： A61K31/4458

    CPC分类号： A61K31/4458

    摘要： Methods of diminishing or eliminating the co-abuse of a methylphenidate drug comprising identifying a patient or patient group suspected or likely to abuse said methylphenidate drug in combination with a substance known or suspected to give rise to l-ethylphenidate or psychotropic effect when ingested in the combination and making available to said patent or patient group said methylphenidate drug substantially free of l-threo methylphenidate.

    摘要翻译： 减少或消除哌甲酯药物的共同滥用的方法包括鉴定怀疑或可能滥用所述哌甲酯类药物的患者或患者组合与已知或怀疑产生1-乙酯或精神药效作用的物质组合， 组合并提供给所述专利或患者组，所述哌甲酯药物基本上不含1-苏式哌甲酯。

    Methods and compositions using immunomodulatory compounds for treatment and management of central nervous system injury
    10.
    发明申请
    Methods and compositions using immunomodulatory compounds for treatment and management of central nervous system injury 审中-公开
    使用免疫调节化合物治疗和治疗中枢神经系统损伤的方法和组合物

    公开(公告)号：US20060122228A1

    公开(公告)日：2006-06-08

    申请号：US11284403

    申请日：2005-11-18

    申请人： Jerome Zeldis ,  Herbert Faleck ,  Donald Manning

    发明人： Jerome Zeldis ,  Herbert Faleck ,  Donald Manning

    IPC分类号： A61K31/454

    CPC分类号： A61K31/454

    摘要： Methods of treating, preventing and/or managing a central nervous system injury/damage and related syndromes are disclosed. Specific methods encompass the administration of an immunomodulatory compound alone or in combination with a second active agent. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

    摘要翻译： 公开了治疗，预防和/或治疗中枢神经系统损伤/损伤及相关综合征的方法。 具体方法包括单独或与第二活性剂组合施用免疫调节化合物。 还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。