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公开(公告)号：US08460650B2
公开(公告)日：2013-06-11
申请号：US12030161
申请日：2008-02-12
申请人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
发明人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
IPC分类号： A01N65/00
CPC分类号： A61K35/50 , A61K35/644 , A61K38/21 , A61K45/06 , A61K2035/122 , C12N5/0605 , C12N2500/25 , C12N2500/36 , C12N2501/11 , C12N2501/135 , C12N2501/39 , A61K2300/00
摘要： Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin syndrome), or scleroderma using placental stem cells or umbilical cord stem cells.
摘要翻译： 本文提供了治疗具有免疫相关疾病，病症或病症的个体的方法，例如炎性肠病，移植物抗宿主病，多发性硬化，类风湿性关节炎，银屑病，红斑狼疮，糖尿病，蕈样真菌病（Alibert -Bazin综合征）或使用胎盘干细胞或脐带干细胞的硬皮病。
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2.发明申请TREATMENT OF RHEUMATOID ARTHRITIS USING PLACENTAL STEM CELLS 审中-公开使用PLACENTAL STEM细胞治疗RHEUMATOID ARTHRITIS公开(公告)号：US20110280845A1
公开(公告)日：2011-11-17
申请号：US13107727
申请日：2011-05-13
申请人： James W. EDINGER , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
发明人： James W. EDINGER , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
CPC分类号： A61K35/50 , A61K35/644 , A61K38/21 , A61K45/06 , A61K2035/122 , C12N5/0605 , C12N2500/25 , C12N2500/36 , C12N2501/11 , C12N2501/135 , C12N2501/39 , A61K2300/00
摘要： Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin syndrome), or scleroderma using placental stem cells or umbilical cord stem cells.
摘要翻译： 本文提供了治疗具有免疫相关疾病，病症或病症的个体的方法，例如炎性肠病，移植物抗宿主病，多发性硬化，类风湿性关节炎，银屑病，红斑狼疮，糖尿病，蕈样真菌病（Alibert -Bazin综合征）或使用胎盘干细胞或脐带干细胞的硬皮病。
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公开(公告)号：US20080226595A1
公开(公告)日：2008-09-18
申请号：US12030161
申请日：2008-02-12
申请人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
发明人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
CPC分类号： A61K35/50 , A61K35/644 , A61K38/21 , A61K45/06 , A61K2035/122 , C12N5/0605 , C12N2500/25 , C12N2500/36 , C12N2501/11 , C12N2501/135 , C12N2501/39 , A61K2300/00
摘要： Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin syndrome), or scleroderma using placental stem cells or umbilical cord stem cells.
摘要翻译： 本文提供了治疗具有免疫相关疾病，病症或病症的个体的方法，例如炎性肠病，移植物抗宿主病，多发性硬化，类风湿性关节炎，银屑病，红斑狼疮，糖尿病，蕈样真菌病（Alibert -Bazin综合征）或使用胎盘干细胞或脐带干细胞的硬皮病。
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公开(公告)号：US08753883B2
公开(公告)日：2014-06-17
申请号：US13107778
申请日：2011-05-13
申请人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
发明人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
CPC分类号： A61K35/50 , A61K35/644 , A61K38/21 , A61K45/06 , A61K2035/122 , C12N5/0605 , C12N2500/25 , C12N2500/36 , C12N2501/11 , C12N2501/135 , C12N2501/39 , A61K2300/00
摘要： Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin syndrome), or scleroderma using placental stem cells or umbilical cord stem cells.
摘要翻译： 本文提供了治疗具有免疫相关疾病，病症或病症的个体的方法，例如炎性肠病，移植物抗宿主病，多发性硬化，类风湿性关节炎，银屑病，红斑狼疮，糖尿病，蕈样真菌病（Alibert -Bazin综合征）或使用胎盘干细胞或脐带干细胞的硬皮病。
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公开(公告)号：US20110280843A1
公开(公告)日：2011-11-17
申请号：US13107778
申请日：2011-05-13
申请人： James W. EDINGER , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
发明人： James W. EDINGER , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
IPC分类号： A61K35/50
CPC分类号： A61K35/50 , A61K35/644 , A61K38/21 , A61K45/06 , A61K2035/122 , C12N5/0605 , C12N2500/25 , C12N2500/36 , C12N2501/11 , C12N2501/135 , C12N2501/39 , A61K2300/00
摘要： Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin syndrome), or scleroderma using placental stem cells or umbilical cord stem cells.
摘要翻译： 本文提供了治疗具有免疫相关疾病，病症或病症的个体的方法，例如炎性肠病，移植物抗宿主病，多发性硬化，类风湿性关节炎，银屑病，红斑狼疮，糖尿病，蕈样真菌病（Alibert -Bazin综合征）或使用胎盘干细胞或脐带干细胞的硬皮病。
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6.发明授权Methods and compositions for treatment of bone defects with placental cell populations 有权用于治疗胎盘细胞群体骨缺损的方法和组合物公开(公告)号：US08562972B2
公开(公告)日：2013-10-22
申请号：US11877475
申请日：2007-10-23
申请人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Kristen S. Labazzo , Marian Pereira , Sascha Dawn Abramson
发明人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Kristen S. Labazzo , Marian Pereira , Sascha Dawn Abramson
CPC分类号： A61K35/50 , A61K9/0019 , A61K35/12 , A61K47/36 , A61K47/42 , A61L27/3834 , A61L27/3847 , C12N5/0605 , C12N5/0654 , C12N5/0668 , C12N2500/38 , C12N2500/42 , C12N2501/39 , C12N2506/025 , C12N2506/03 , C12N2533/18 , C12N2533/54
摘要： Provided herein are methods of using adherent placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. Also provided herein are methods of differentiating the placental stem cells. Further provided herein are methods of using the placental stem cells to formulate implantable or injectable compositions suitable for administration to a subject. Still further provided herein are provides methods for treating bone defects with stem cells and compositions comprising stem cells.
摘要翻译： 本文提供了使用粘附性胎盘干细胞和胎盘干细胞群的方法，以及培养，增殖和扩增其的方法。 本文还提供了区分胎盘干细胞的方法。 本文进一步提供了使用胎盘干细胞来配制适于给予受试者的可植入或可注射组合物的方法。 本文进一步提供的是用干细胞治疗骨缺损的方法和包含干细胞的组合物。
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7.发明申请公开(公告)号：US20080213228A1
公开(公告)日：2008-09-04
申请号：US11877475
申请日：2007-10-23
申请人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Kristen S. Labazzo , Marian Pereira , Sascha Dawn Abramson
发明人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Kristen S. Labazzo , Marian Pereira , Sascha Dawn Abramson
CPC分类号： A61K35/50 , A61K9/0019 , A61K35/12 , A61K47/36 , A61K47/42 , A61L27/3834 , A61L27/3847 , C12N5/0605 , C12N5/0654 , C12N5/0668 , C12N2500/38 , C12N2500/42 , C12N2501/39 , C12N2506/025 , C12N2506/03 , C12N2533/18 , C12N2533/54
摘要： Provided herein are methods of using adherent placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. Also provided herein are methods of differentiating the placental stem cells. Further provided herein are methods of using the placental stem cells to formulate implantable or injectable compositions suitable for administration to a subject. Still further provided herein are provides methods for treating bone defects with stem cells and compositions comprising stem cells.
摘要翻译： 本文提供了使用粘附性胎盘干细胞和胎盘干细胞群的方法，以及培养，增殖和扩增其的方法。 本文还提供了区分胎盘干细胞的方法。 本文进一步提供了使用胎盘干细胞来配制适于给予受试者的可植入或可注射组合物的方法。 本文进一步提供的是用干细胞治疗骨缺损的方法和包含干细胞的组合物。
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8.发明申请Hepatocytes and Chondrocytes from Adherent Placental StemCells; And CD34+ ,CD45- Placental Stem Cell-Enriched Cell Populations 审中-公开来自粘附胎盘干细胞的肝细胞和软骨细胞; 和CD34 +，CD45-胎盘干细胞富集细胞群体公开(公告)号：US20080206343A1
公开(公告)日：2008-08-28
申请号：US12030170
申请日：2008-02-12
申请人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Marian Pereira , Sascha Dawn Abramson , Kristen S. Labazzo
发明人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Marian Pereira , Sascha Dawn Abramson , Kristen S. Labazzo
CPC分类号： C12N5/067 , A01K67/0271 , A01K2267/0337 , A61K2035/128 , C12N5/0605 , C12N5/0607 , C12N5/0655 , C12N2500/30 , C12N2500/36 , C12N2500/62 , C12N2501/15 , C12N2501/999 , C12N2506/02 , C12N2506/03 , C12N2533/32 , C12N2533/40 , C12N2533/74
摘要： Provided herein are methods and compositions for the production of hepatocytes from placenta stem cells. Further provided herein is the use of such hepatocytes in the treatment of, and intervention in, for example, trauma, inflammation, and degenerative disorders of the liver. Also provided herein are compositions and methods relating to combinations of nanofibrous scaffolds and adherent placental stem cells and methods of using the same in cartilage repair. Finally, provided herein are compositions and methods relating to nonadherent, CD34+CD45− stem cells from placenta.
摘要翻译： 本文提供了用于从胎盘干细胞产生肝细胞的方法和组合物。 本文进一步提供的是这种肝细胞在治疗和干预例如肝脏的创伤，炎症和退行性疾病中的用途。 本文还提供了与纳米纤维支架和粘附性胎盘干细胞的组合相关的组合物和方法及其在软骨修复中的使用方法。 最后，本文提供的是与来自胎盘的非粘附的CD34 + CD45 +干细胞相关的组合物和方法。
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公开(公告)号：US09254302B2
公开(公告)日：2016-02-09
申请号：US13081415
申请日：2011-04-06
申请人： Stewart Abbot , James W. Edinger , Aleksandar Francki , Robert J. Hariri , Vladimir Jankovic , Aleksandr Kaplunovsky , Kristen Labazzo , Eric Law , Neerav D. Padliya , Jennifer Paredes , Jia-Lun Wang
发明人： Stewart Abbot , James W. Edinger , Aleksandar Francki , Robert J. Hariri , Vladimir Jankovic , Aleksandr Kaplunovsky , Kristen Labazzo , Eric Law , Neerav D. Padliya , Jennifer Paredes , Jia-Lun Wang
CPC分类号： A61K35/50 , A61K9/0019 , A61K9/0085 , A61K35/28 , A61L27/3633 , A61L27/3683 , A61L27/3808 , A61L27/3834 , A61L27/3886 , A61L27/3895 , C12N5/0605 , A61K2300/00
摘要： Provided herein are methods of treating individuals having diseases or disorders of the circulatory system, using placental cells, e.g., the placental stem cells and placental multipotent cells (PDACs) described herein, and populations of such placental cells. The invention also provides methods of angiogenesis using such cells or populations of cells comprising such cells.
摘要翻译： 本文提供了使用胎盘细胞（例如本文所述的胎盘干细胞和胎盘多潜能细胞（PDAC））以及这些胎盘细胞群来治疗患有循环系统疾病或病症的个体的方法。 本发明还提供了使用这种细胞或包含这种细胞的细胞群的血管生成方法。
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10.发明申请ORGANOIDS COMPRISING DECELLULARIZED AND REPOPULATED PLACENTAL VASCULAR SCAFFOLD 审中-公开包含细胞扩增和扩增的特异性血管性SCAFFOLD的组织公开(公告)号：US20150017140A1
公开(公告)日：2015-01-15
申请号：US14367631
申请日：2012-12-21
CPC分类号： A61L27/3804 , A61K31/167 , A61K31/192 , A61K31/616 , A61K35/12 , A61K35/22 , A61K35/39 , A61K35/407 , A61K35/50 , A61K35/51 , A61K35/55 , A61K38/13 , A61K45/06 , A61L27/16 , A61L27/3625 , A61L27/3683 , A61L27/3691 , A61L27/3834 , A61L27/3886 , A61L27/48 , A61L27/54 , A61L2300/252 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2300/43 , A61L2430/40 , A61P3/00 , A61P5/00 , A61P15/08 , C12N5/0062 , C12N5/0605 , C12N5/0617 , C12N5/0639 , C12N5/0646 , C12N5/0647 , C12N5/065 , C12N2533/92 , C08L89/00 , A61K2300/00
摘要： Provided herein are organoids comprising decellularized placental vascular scaffold comprising, or consisting of, a decellularized placental vascular scaffold, and methods of making and using the same.
摘要翻译： 本文提供了包含脱细胞胎盘血管支架的组织细胞，其包含脱细胞胎盘血管支架，或由脱细胞化胎盘血管支架组成，以及制备和使用其的方法。
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