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公开(公告)号：US20080118517A1
公开(公告)日：2008-05-22
申请号：US11823481
申请日：2007-06-27
申请人： Jessica Teeling , Paul Parren , Ole Baadsgaard , Debra Hudson , Jorgen Petersen
发明人： Jessica Teeling , Paul Parren , Ole Baadsgaard , Debra Hudson , Jorgen Petersen
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/4241 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , G01N33/6869
摘要： Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, hybridomas, and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了与IL-8结合的分离的人单克隆抗体（例如人IL-8）。 人抗体可以通过进行V-D-J重组和同种型转换，在能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人转基因动物例如转基因小鼠中产生。 还公开了包含人抗体，非人转基因动物，杂交瘤和产生人抗体的转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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2.发明授权Methods of treating cancer with human monoclonal antibodies against interleukin 8 有权用针对白介素8的人单克隆抗体治疗癌症的方法公开(公告)号：US08603469B2
公开(公告)日：2013-12-10
申请号：US13337798
申请日：2011-12-27
申请人： Jessica Teeling , Paul Parren , Ole Baadsgaard , Debra Hudson , Jorgen Petersen
发明人： Jessica Teeling , Paul Parren , Ole Baadsgaard , Debra Hudson , Jorgen Petersen
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/4241 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , G01N33/6869
摘要： Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, hybridomas, and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了与IL-8结合的分离的人单克隆抗体（例如人IL-8）。 人抗体可以通过进行V-D-J重组和同种型转换，在能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人转基因动物例如转基因小鼠中产生。 还公开了包含人抗体，非人转基因动物，杂交瘤和产生人抗体的转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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公开(公告)号：US08105588B2
公开(公告)日：2012-01-31
申请号：US12616615
申请日：2009-11-11
申请人： Jessica Teeling , Paul Parren , Ole Baadsgaard , Debra Hudson , Jorgen Petersen
发明人： Jessica Teeling , Paul Parren , Ole Baadsgaard , Debra Hudson , Jorgen Petersen
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/4241 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , G01N33/6869
摘要： Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, hybridomas, and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了与IL-8结合的分离的人单克隆抗体（例如人IL-8）。 人抗体可以通过进行V-D-J重组和同种型转换，在能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人转基因动物例如转基因小鼠中产生。 还公开了包含人抗体，非人转基因动物，杂交瘤和产生人抗体的转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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公开(公告)号：US07282568B2
公开(公告)日：2007-10-16
申请号：US10738120
申请日：2003-12-16
申请人： Jessica Teeling , Paul Parren , Ole Baadsgaard , Debra Hudson , Jørgen Petersen
发明人： Jessica Teeling , Paul Parren , Ole Baadsgaard , Debra Hudson , Jørgen Petersen
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/4241 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , G01N33/6869
摘要： Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, hybridomas, and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了与IL-8结合的分离的人单克隆抗体（例如人IL-8）。 人抗体可以通过进行V-D-J重组和同种型转换，在能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人转基因动物例如转基因小鼠中产生。 还公开了包含人抗体，非人转基因动物，杂交瘤和产生人抗体的转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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公开(公告)号：US07622559B2
公开(公告)日：2009-11-24
申请号：US11823481
申请日：2007-06-27
申请人： Jessica Teeling , Paul Parren , Ole Baadsgaard , Debra Hudson , Jørgen Petersen
发明人： Jessica Teeling , Paul Parren , Ole Baadsgaard , Debra Hudson , Jørgen Petersen
IPC分类号： A61K39/00
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/4241 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , G01N33/6869
摘要： Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, hybridomas, and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了与IL-8结合的分离的人单克隆抗体（例如人IL-8）。 人抗体可以通过进行V-D-J重组和同种型转换，在能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人转基因动物例如转基因小鼠中产生。 还公开了包含人抗体，非人转基因动物，杂交瘤和产生人抗体的转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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公开(公告)号：US08529902B2
公开(公告)日：2013-09-10
申请号：US10687799
申请日：2003-10-17
申请人： Jessica Teeling , Sigrid Ruuls , Martin Glennie , Jan G. J. van de Winkel , Paul Parren , Jørgen Petersen , Ole Baadsgaard , Haichun Huang
发明人： Jessica Teeling , Sigrid Ruuls , Martin Glennie , Jan G. J. van de Winkel , Paul Parren , Jørgen Petersen , Ole Baadsgaard , Haichun Huang
IPC分类号： C07K16/18 , C07K16/28 , C07K16/30 , A61K39/395 , C12N5/12
CPC分类号： C07K16/2887 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/4258 , C07K2317/21 , C07K2317/54 , C07K2317/56 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/92 , G01N33/686
摘要： Isolated human monoclonal antibodies which bind to and inhibit human CD20, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了结合并抑制人CD20的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的转染瘤或非人转基因动物例如转基因小鼠产生。 还公开了包含人抗体，非人转基因动物和产生人抗体的杂交瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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公开(公告)号：US08182812B2
公开(公告)日：2012-05-22
申请号：US12283775
申请日：2008-09-16
申请人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jorgen Petersen , Ole Baadsgaard
发明人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jorgen Petersen , Ole Baadsgaard
IPC分类号： A61K39/395 , A61P37/02 , A61P37/08 , G01N33/53
CPC分类号： C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/062 , C07K16/4258 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/56966 , G01N33/57492 , G01N33/6854 , G01N33/6869 , G01N2333/70596 , G01N2333/715 , G01N2333/7155
摘要： Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了结合并抑制人CD25的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人类转基因动物例如转基因小鼠产生。 还公开了包含人抗体，非人转基因动物，产生人抗体的杂交瘤和转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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公开(公告)号：US20090155204A1
公开(公告)日：2009-06-18
申请号：US12291494
申请日：2008-11-11
IPC分类号： A61K38/20 , A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/73 , Y02A50/41
摘要： Methods for treating disorders involving monocytic activity by administering IL-15 antagonists that induce apoptosis of monocytes are disclosed.
摘要翻译： 公开了通过施用诱导单核细胞凋亡的IL-15拮抗剂来治疗涉及单核细胞活性的疾病的方法。
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公开(公告)号：US20090081219A1
公开(公告)日：2009-03-26
申请号：US12283775
申请日：2008-09-16
申请人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G.J. Van De Winkel , Denise Leah Williams , Jorgen Petersen , Ole Baadsgaard
发明人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G.J. Van De Winkel , Denise Leah Williams , Jorgen Petersen , Ole Baadsgaard
IPC分类号： A61K39/395 , G01N33/53 , A61P37/02 , A61P37/08
CPC分类号： C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/062 , C07K16/4258 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/56966 , G01N33/57492 , G01N33/6854 , G01N33/6869 , G01N2333/70596 , G01N2333/715 , G01N2333/7155
摘要： Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了结合并抑制人CD25的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人类转基因动物例如转基因小鼠产生。 还公开了包含人抗体，非人转基因动物，产生人抗体的杂交瘤和转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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公开(公告)号：US20050123542A1
公开(公告)日：2005-06-09
申请号：US10982725
申请日：2004-11-04
IPC分类号： C07K16/24 , A61K39/395 , A61K38/17 , A61K38/20
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/73 , Y02A50/41
摘要： Methods for treating disorders involving monocytic activity by administering IL-15 antagonists that induce apoptosis of monocytes are disclosed.
摘要翻译： 公开了通过施用诱导单核细胞凋亡的IL-15拮抗剂来治疗涉及单核细胞活性的疾病的方法。
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