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公开(公告)号：US20090155204A1
公开(公告)日：2009-06-18
申请号：US12291494
申请日：2008-11-11
IPC分类号： A61K38/20 , A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/73 , Y02A50/41
摘要： Methods for treating disorders involving monocytic activity by administering IL-15 antagonists that induce apoptosis of monocytes are disclosed.
摘要翻译： 公开了通过施用诱导单核细胞凋亡的IL-15拮抗剂来治疗涉及单核细胞活性的疾病的方法。
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公开(公告)号：US20050123542A1
公开(公告)日：2005-06-09
申请号：US10982725
申请日：2004-11-04
IPC分类号： C07K16/24 , A61K39/395 , A61K38/17 , A61K38/20
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/73 , Y02A50/41
摘要： Methods for treating disorders involving monocytic activity by administering IL-15 antagonists that induce apoptosis of monocytes are disclosed.
摘要翻译： 公开了通过施用诱导单核细胞凋亡的IL-15拮抗剂来治疗涉及单核细胞活性的疾病的方法。
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公开(公告)号：US08182812B2
公开(公告)日：2012-05-22
申请号：US12283775
申请日：2008-09-16
申请人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jorgen Petersen , Ole Baadsgaard
发明人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jorgen Petersen , Ole Baadsgaard
IPC分类号： A61K39/395 , A61P37/02 , A61P37/08 , G01N33/53
CPC分类号： C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/062 , C07K16/4258 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/56966 , G01N33/57492 , G01N33/6854 , G01N33/6869 , G01N2333/70596 , G01N2333/715 , G01N2333/7155
摘要： Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了结合并抑制人CD25的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人类转基因动物例如转基因小鼠产生。 还公开了包含人抗体，非人转基因动物，产生人抗体的杂交瘤和转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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公开(公告)号：US20090081219A1
公开(公告)日：2009-03-26
申请号：US12283775
申请日：2008-09-16
申请人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G.J. Van De Winkel , Denise Leah Williams , Jorgen Petersen , Ole Baadsgaard
发明人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G.J. Van De Winkel , Denise Leah Williams , Jorgen Petersen , Ole Baadsgaard
IPC分类号： A61K39/395 , G01N33/53 , A61P37/02 , A61P37/08
CPC分类号： C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/062 , C07K16/4258 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/56966 , G01N33/57492 , G01N33/6854 , G01N33/6869 , G01N2333/70596 , G01N2333/715 , G01N2333/7155
摘要： Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了结合并抑制人CD25的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人类转基因动物例如转基因小鼠产生。 还公开了包含人抗体，非人转基因动物，产生人抗体的杂交瘤和转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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公开(公告)号：US20130189271A1
公开(公告)日：2013-07-25
申请号：US13700341
申请日：2011-05-27
申请人： Bart De Goeij , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , Jan Van De Winkel , David Satijn , Paul Parren , Aran Frank Labrijn , Joyce I. Meesters , Janine Schuurman , Edward Norbert Van Den Brink
发明人： Bart De Goeij , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , Jan Van De Winkel , David Satijn , Paul Parren , Aran Frank Labrijn , Joyce I. Meesters , Janine Schuurman , Edward Norbert Van Den Brink
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2809 , C07K16/32 , C07K2317/31 , C07K2317/52 , C07K2317/526 , C07K2317/528 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要： Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related anti-body-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
摘要翻译： 公开了与人表皮生长因子受体2（HER2）结合的分离的单克隆抗体以及相关的抗体基组合物和分子。 还公开了包含抗体的药物组合物和使用抗体的治疗和诊断方法。
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公开(公告)号：US07438907B2
公开(公告)日：2008-10-21
申请号：US10714353
申请日：2003-11-14
申请人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jørgen Petersen , Ole Baadsgaard
发明人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jørgen Petersen , Ole Baadsgaard
IPC分类号： A61K39/00 , A61K39/395 , C07K16/00
CPC分类号： C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/062 , C07K16/4258 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/56966 , G01N33/57492 , G01N33/6854 , G01N33/6869 , G01N2333/70596 , G01N2333/715 , G01N2333/7155
摘要： Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了结合并抑制人CD25的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人类转基因动物例如转基因小鼠产生。 还公开了包含人抗体，非人转基因动物，产生人抗体的杂交瘤和转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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公开(公告)号：US09862769B2
公开(公告)日：2018-01-09
申请号：US13700341
申请日：2011-05-27
申请人： Bart De Goeij , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , Jan Van De Winkel , David Satijn , Paul Parren , Aran Frank Labrijn , Joyce Meesters , Janine Schuurman , Edward N. Van Den Brink
发明人： Bart De Goeij , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , Jan Van De Winkel , David Satijn , Paul Parren , Aran Frank Labrijn , Joyce Meesters , Janine Schuurman , Edward N. Van Den Brink
IPC分类号： A61K39/395 , C07K16/00 , C07K16/28 , C07K16/32 , A61K39/00
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2809 , C07K16/32 , C07K2317/31 , C07K2317/52 , C07K2317/526 , C07K2317/528 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要： Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related anti-body-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：US08961968B2
公开(公告)日：2015-02-24
申请号：US13465181
申请日：2012-05-07
申请人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jørgen Petersen , Ole Baadsgaard
发明人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jørgen Petersen , Ole Baadsgaard
IPC分类号： C07K16/28 , C07K17/00 , G01N33/577 , A61K51/10 , A61K39/395 , G01N33/68 , A61K39/00
CPC分类号： C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/062 , C07K16/4258 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/56966 , G01N33/57492 , G01N33/6854 , G01N33/6869 , G01N2333/70596 , G01N2333/715 , G01N2333/7155
摘要： Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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9.发明申请METHOD FOR EXTENDING THE HALF-LIFE OF EXOGENOUS OR ENDOGENOUS SOLUBLE MOLECULES 审中-公开扩增异源或内源可溶性分子半衰期的方法公开(公告)号：US20100291023A1
公开(公告)日：2010-11-18
申请号：US12602434
申请日：2008-05-30
申请人： Janine Schuurman , Tom Vink , Jan Van de Winkel , Aran Frank Labrijn , Paul Parren , Frank Beurskens , Willem Karel Bleeker , Patrick Van Berkel
发明人： Janine Schuurman , Tom Vink , Jan Van de Winkel , Aran Frank Labrijn , Paul Parren , Frank Beurskens , Willem Karel Bleeker , Patrick Van Berkel
IPC分类号： A61K38/20 , A61K38/21 , A61K39/395 , C07K16/44 , C07K16/42
CPC分类号： C07K16/283 , C07K16/2812 , C07K16/2863 , C07K16/2887 , C07K2317/732
摘要： The present invention relates to methods for extending the in vivo half-life of an exogenous soluble therapeutic molecule administered to a subject, by administering to said subject the exogenous soluble molecule and a monovalent antibody that binds to the exogenous soluble molecule, as well as method for treating a disease or disorder associated with an insufficient level of an endogenous soluble molecule in a subject, by administering to said subject a monovalent antibody that binds to the endogenous soluble molecule.
摘要翻译： 本发明涉及通过向所述受试者施用外源可溶性分子和结合外源可溶性分子的单价抗体以及方法，用于延长给予受试者的外源可溶性治疗分子的体内半衰期的方法，以及方法 用于治疗与受试者内源性可溶性分子水平不足相关的疾病或病症，通过向所述受试者施用结合内源性可溶性分子的单价抗体。
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公开(公告)号：US20140242075A1
公开(公告)日：2014-08-28
申请号：US14130543
申请日：2012-07-06
IPC分类号： C07K16/28
摘要： Described herein are polypeptides and related antibodies comprising a variant Fc domain. The variant Fc domain provide for stabilized Fc:Fc interactions when the polypeptide(s), antibody or antibodies are bound to its target, antigen or antigens on the surface of a cell, thus providing for improved effector functions, such as CDC-response.
摘要翻译： 本文描述的是包含变体Fc结构域的多肽和相关抗体。 当多肽，抗体或抗体与细胞表面上的其靶标，抗原或抗原结合时，变体Fc结构域提供稳定的Fc：Fc相互作用，从而提供改善的效应子功能，例如CDC反应。
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