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公开(公告)号：US08182812B2
公开(公告)日：2012-05-22
申请号：US12283775
申请日：2008-09-16
申请人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jorgen Petersen , Ole Baadsgaard
发明人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jorgen Petersen , Ole Baadsgaard
IPC分类号： A61K39/395 , A61P37/02 , A61P37/08 , G01N33/53
CPC分类号： C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/062 , C07K16/4258 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/56966 , G01N33/57492 , G01N33/6854 , G01N33/6869 , G01N2333/70596 , G01N2333/715 , G01N2333/7155
摘要： Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了结合并抑制人CD25的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人类转基因动物例如转基因小鼠产生。 还公开了包含人抗体，非人转基因动物，产生人抗体的杂交瘤和转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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公开(公告)号：US07438907B2
公开(公告)日：2008-10-21
申请号：US10714353
申请日：2003-11-14
申请人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jørgen Petersen , Ole Baadsgaard
发明人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jørgen Petersen , Ole Baadsgaard
IPC分类号： A61K39/00 , A61K39/395 , C07K16/00
CPC分类号： C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/062 , C07K16/4258 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/56966 , G01N33/57492 , G01N33/6854 , G01N33/6869 , G01N2333/70596 , G01N2333/715 , G01N2333/7155
摘要： Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了结合并抑制人CD25的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人类转基因动物例如转基因小鼠产生。 还公开了包含人抗体，非人转基因动物，产生人抗体的杂交瘤和转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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公开(公告)号：US09580506B2
公开(公告)日：2017-02-28
申请号：US11989064
申请日：2006-07-21
IPC分类号： G01N33/53 , C07K16/28 , G01N33/566 , C07K16/00
CPC分类号： C07K16/2812 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/732 , C07K2317/76 , G01N33/566 , G01N2333/70535
摘要： The invention relates to a method of characterizing an antibody, which method is suitable as a potency assay for batch release of a pharmaceutical composition comprising an antibody, specifically for use when applying for marketing authorization for said pharmaceutical composition. The assay provided is a method for determining the potency of a drug product comprising an FcR binding peptide, wherein at least one mechanism of action of the FcR binding peptide of the drug product is mediated through the binding of the FcR binding peptide of the drug product to a Fc receptor, wherein said method comprises determining the binding of the FcR binding peptide of the drug product to an Fc receptor.
摘要翻译： 本发明涉及一种表征抗体的方法，该方法适用于批量释放包含抗体的药物组合物的效力测定，该抗体特别用于在申请所述药物组合物的营销授权时使用。 提供的测定法是用于测定包含FcR结合肽的药物产品的效力的方法，其中药物产物的FcR结合肽的至少一种作用机制是通过药物产物的FcR结合肽的结合来介导的 其中所述方法包括测定药物产物的FcR结合肽与Fc受体的结合。
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公开(公告)号：US08961968B2
公开(公告)日：2015-02-24
申请号：US13465181
申请日：2012-05-07
申请人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jørgen Petersen , Ole Baadsgaard
发明人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jørgen Petersen , Ole Baadsgaard
IPC分类号： C07K16/28 , C07K17/00 , G01N33/577 , A61K51/10 , A61K39/395 , G01N33/68 , A61K39/00
CPC分类号： C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/062 , C07K16/4258 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/56966 , G01N33/57492 , G01N33/6854 , G01N33/6869 , G01N2333/70596 , G01N2333/715 , G01N2333/7155
摘要： Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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公开(公告)号：US20100015644A1
公开(公告)日：2010-01-21
申请号：US11989064
申请日：2006-07-21
IPC分类号： G01N33/53 , G01N33/566 , C07K16/18 , C12M1/22
CPC分类号： C07K16/2812 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/732 , C07K2317/76 , G01N33/566 , G01N2333/70535
摘要： The invention relates to a method of characterizing an antibody, which method is suitable as a potency assay for batch release of a pharmaceutical composition comprising an antibody, specifically for use when applying for marketing authorization for said pharmaceutical composition. The assay provided is a method for determining the potency of a drug product comprising an FcR binding peptide, wherein at least one mechanism of action of the FcR binding peptide of the drug product is mediated through the binding of the FcR binding peptide of the drug product to a Fc receptor, wherein said method comprises determining the binding of the FcR binding peptide of the drug product to an Fc receptor.
摘要翻译： 本发明涉及一种表征抗体的方法，该方法适用于批量释放包含抗体的药物组合物的效力测定，该抗体特别用于在申请所述药物组合物的营销授权时使用。 提供的测定法是用于测定包含FcR结合肽的药物产品的效力的方法，其中药物产物的FcR结合肽的至少一种作用机制是通过药物产物的FcR结合肽的结合来介导的 其中所述方法包括测定药物产物的FcR结合肽与Fc受体的结合。
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公开(公告)号：US20090081219A1
公开(公告)日：2009-03-26
申请号：US12283775
申请日：2008-09-16
申请人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G.J. Van De Winkel , Denise Leah Williams , Jorgen Petersen , Ole Baadsgaard
发明人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G.J. Van De Winkel , Denise Leah Williams , Jorgen Petersen , Ole Baadsgaard
IPC分类号： A61K39/395 , G01N33/53 , A61P37/02 , A61P37/08
CPC分类号： C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/062 , C07K16/4258 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/56966 , G01N33/57492 , G01N33/6854 , G01N33/6869 , G01N2333/70596 , G01N2333/715 , G01N2333/7155
摘要： Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了结合并抑制人CD25的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人类转基因动物例如转基因小鼠产生。 还公开了包含人抗体，非人转基因动物，产生人抗体的杂交瘤和转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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公开(公告)号：US20120244069A1
公开(公告)日：2012-09-27
申请号：US13465181
申请日：2012-05-07
申请人： Janine SCHUURMAN , Catharina Emanuele Gerarda HAVENITH , Paul PARREN , Jan G. J. VAN DE WINKEL , Denise Leah WILLIAMS , Jørgen PETERSEN , Ole BAADSGAARD
发明人： Janine SCHUURMAN , Catharina Emanuele Gerarda HAVENITH , Paul PARREN , Jan G. J. VAN DE WINKEL , Denise Leah WILLIAMS , Jørgen PETERSEN , Ole BAADSGAARD
IPC分类号： A61K39/395 , A61K51/10 , C07K16/28 , A61P19/02 , A61P3/10 , A61N5/06 , A61P21/04 , A61P1/00 , A61P1/04 , A61P11/06 , G01N33/577 , A61M37/00 , C07K17/00 , A61P25/00
CPC分类号： C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/062 , C07K16/4258 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/56966 , G01N33/57492 , G01N33/6854 , G01N33/6869 , G01N2333/70596 , G01N2333/715 , G01N2333/7155
摘要： Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了结合并抑制人CD25的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人类转基因动物例如转基因小鼠产生。 还公开了包含人抗体，非人转基因动物，产生人抗体的杂交瘤和转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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