公开(公告)号：US20050147565A1

公开(公告)日：2005-07-07

申请号：US11071078

申请日：2005-03-03

申请人： Joel Sequeira ,  Stefan Sharpe ,  John Hart

发明人： Joel Sequeira ,  Stefan Sharpe ,  John Hart

IPC分类号： A61K9/12 ,  A61K9/00 ,  A61K9/70 ,  A61K31/00 ,  A61K31/167 ,  A61K31/573 ,  A61K31/58 ,  A61K47/06 ,  A61K47/12 ,  A61K47/24 ,  A61K47/26 ,  A61P11/06 ,  A61P29/00 ,  A61P37/08 ,  A61L9/04 ,  A61M11/00

CPC分类号： A61K9/008 ,  A61K31/58 ,  A61K2300/00

摘要： Disclosed are aerosolized formulations for the treatment of asthma that contain mometasone furoate and formoterol fumarate and processes for preparing the same.

摘要翻译： 公开了用于治疗含有糠酸莫米他松和富马酸福莫特罗的哮喘的雾化制剂及其制备方法。

公开(公告)号：US20110244004A1

公开(公告)日：2011-10-06

申请号：US13161097

申请日：2011-06-15

申请人： Stefan Sharpe ,  Joel Sequeira ,  David Harris ,  Shashank Mahashabde

发明人： Stefan Sharpe ,  Joel Sequeira ,  David Harris ,  Shashank Mahashabde

IPC分类号： A61K31/496 ,  A61K9/14 ,  A61P31/10

CPC分类号： A61K31/496 ,  A01N43/653 ,  A61K9/0095 ,  A61K9/10 ,  A01N25/30 ,  A01N25/10 ,  A01N25/04 ,  A01N2300/00

摘要： A liquid suspension comprising an antifungally effective amount of the micronized compound represented by the chemical structural formula I: at least one thickening agent, a non-ionic surfactant, and a pharmaceutically acceptable liquid carrier is disclosed.

摘要翻译： 公开了一种包含抗真菌有效量的由化学结构式I表示的微粉化化合物的液体悬浮液：至少一种增稠剂，非离子表面活性剂和药学上可接受的液体载体。

公开(公告)号：US08263600B2

公开(公告)日：2012-09-11

申请号：US13161097

申请日：2011-06-15

申请人： Stefan Sharpe ,  Joel Sequeira ,  David Harris ,  Shashank Mahashabde

发明人： Stefan Sharpe ,  Joel Sequeira ,  David Harris ,  Shashank Mahashabde

IPC分类号： A61K31/497

CPC分类号： A61K31/496 ,  A01N43/653 ,  A61K9/0095 ,  A61K9/10 ,  A01N25/30 ,  A01N25/10 ,  A01N25/04 ,  A01N2300/00

摘要： A liquid suspension comprising an antifungally effective amount of the micronized compound represented by the chemical structural formula I: at least one thickening agent, a non-ionic surfactant, and a pharmaceutically acceptable liquid carrier is disclosed.

摘要翻译： 公开了一种包含抗真菌有效量的由化学结构式I表示的微粉化化合物的液体悬浮液：至少一种增稠剂，非离子表面活性剂和药学上可接受的液体载体。

公开(公告)号：US20080066744A1

公开(公告)日：2008-03-20

申请号：US11948688

申请日：2007-11-30

申请人： Saeed Chaudhry ,  Stefan Sharpe ,  Julianne Berry ,  Joel Sequeira

发明人： Saeed Chaudhry ,  Stefan Sharpe ,  Julianne Berry ,  Joel Sequeira

IPC分类号： A61M11/04 ,  A61K9/14

CPC分类号： B65B3/003 ,  A61M11/04 ,  A61M15/0065 ,  B65B31/003

摘要： Disclosed are methods of introducing a suspension or solution of a medicament, preferably mometasone furoate anhydrous, into a metered dose inhaler container, said container having a valve attached thereto, said method comprising the steps of introducing mometasone furoate anhydrous, a surfactant and a chlorofluorocarbon free propellant into a vessel that is held under pressure to form a suspension or solution, circulating said suspension or solution from the vessel through a line which includes a filling head, bringing said filling head into communication with said metered dose inhaler container through said valve of said metered dose inhaler container, introducing a quantity of such suspension or solution into the container from the filling head of the line through said valve of said metered dose inhaler container, withdrawing said filling head from said metered dose inhaler container, and sealing said metered dose inhaler container, as well as the products produced thereby having an improved particle size distribution of the active ingredients in metered dose inhalers.

摘要翻译： 公开了将药物，优选无糠酸莫米他松无水物质的悬浮液或溶液引入计量吸入器容器中的方法，所述容器具有附着于其上的阀，所述方法包括以下步骤：将无糠酸莫米松，无表面活性剂和不含氯氟烃的引入 推进剂进入保持在压力下以形成悬浮液或溶液的容器中，使来自容器的悬浮液或溶液通过包括填充头的管线循环，使所述填充头与所述计量剂量吸入器容器连通，通过所述阀 计量吸入器容器，通过所述计量吸入器容器的所述阀从管线的填充头将一定数量的这种悬浮液或溶液引入容器中，从所述计量吸入器容器中取出所述填充头，并密封所述计量剂量吸入器 集装箱，以及由此生产的产品 改进计量吸入器中活性成分的粒度分布。