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    PROCESS FOR PRODUCING METERED DOSE INHALER FORMULATIONS
    1.
    发明申请
    PROCESS FOR PRODUCING METERED DOSE INHALER FORMULATIONS 审中-公开
    生产计量剂量吸入剂制剂的方法

    公开(公告)号：US20080066744A1

    公开(公告)日：2008-03-20

    申请号：US11948688

    申请日：2007-11-30

    申请人： Saeed Chaudhry ,  Stefan Sharpe ,  Julianne Berry ,  Joel Sequeira

    发明人： Saeed Chaudhry ,  Stefan Sharpe ,  Julianne Berry ,  Joel Sequeira

    IPC分类号： A61M11/04 ,  A61K9/14

    CPC分类号： B65B3/003 ,  A61M11/04 ,  A61M15/0065 ,  B65B31/003

    摘要： Disclosed are methods of introducing a suspension or solution of a medicament, preferably mometasone furoate anhydrous, into a metered dose inhaler container, said container having a valve attached thereto, said method comprising the steps of introducing mometasone furoate anhydrous, a surfactant and a chlorofluorocarbon free propellant into a vessel that is held under pressure to form a suspension or solution, circulating said suspension or solution from the vessel through a line which includes a filling head, bringing said filling head into communication with said metered dose inhaler container through said valve of said metered dose inhaler container, introducing a quantity of such suspension or solution into the container from the filling head of the line through said valve of said metered dose inhaler container, withdrawing said filling head from said metered dose inhaler container, and sealing said metered dose inhaler container, as well as the products produced thereby having an improved particle size distribution of the active ingredients in metered dose inhalers.

    摘要翻译： 公开了将药物，优选无糠酸莫米他松无水物质的悬浮液或溶液引入计量吸入器容器中的方法，所述容器具有附着于其上的阀，所述方法包括以下步骤：将无糠酸莫米松，无表面活性剂和不含氯氟烃的引入 推进剂进入保持在压力下以形成悬浮液或溶液的容器中，使来自容器的悬浮液或溶液通过包括填充头的管线循环，使所述填充头与所述计量剂量吸入器容器连通，通过所述阀 计量吸入器容器，通过所述计量吸入器容器的所述阀从管线的填充头将一定数量的这种悬浮液或溶液引入容器中，从所述计量吸入器容器中取出所述填充头，并密封所述计量剂量吸入器 集装箱，以及由此生产的产品 改进计量吸入器中活性成分的粒度分布。

    Pharmaceutical compositions
    3.
    发明申请
    Pharmaceutical compositions 审中-公开
    药物组合物

    公开(公告)号：US20050136009A1

    公开(公告)日：2005-06-23

    申请号：US10967719

    申请日：2004-10-18

    申请人： Julianne Berry ,  Jill Sherwood ,  Saeed Chaudhry ,  Joel Sequeira

    发明人： Julianne Berry ,  Jill Sherwood ,  Saeed Chaudhry ,  Joel Sequeira

    IPC分类号： A61K9/00 ,  A61K9/12 ,  A61K9/14 ,  A61K31/58 ,  A61L9/04 ,  A61M11/00

    CPC分类号： A61K9/008 ,  A61K9/12 ,  A61K9/124 ,  A61K31/58 ,  A61K2300/00

    摘要： Disclosed are metered dose inhalers having a metering valve to deliver a dose containing an aerosol suspension formulation, said aerosol suspension formulation comprising: an effective amount of Mometasone Furoate, Formoterol or a combination thereof; a suspension medium selected from the group consisting of 1,1,1,2,3,3,3,-heptafluoropropane, 1,1,1,2-tetrafluoroethane; and a solvent that is ethanol; wherein said formulation contains less than about 500 μg of non-volatile residue as measured by ultraviolet spectroscopy.

    摘要翻译： 公开了具有计量阀以计量含有气溶胶悬浮液制剂的计量剂量吸入器，所述气溶胶悬浮液制剂包含：有效量的糠酸莫米松，福莫特罗或其组合; 选自1,1,1,2,3,3,3， - 七氟丙烷，1,1,1,2-四氟乙烷的悬浮介质; 和乙醇的溶剂; 其中所述制剂含有通过紫外光谱测量的小于约500杯非挥发性残余物。

    Chlorofluorocarbon-free mometasone furoate aerosol formulations
    7.
    发明授权
    Chlorofluorocarbon-free mometasone furoate aerosol formulations 失效
    不含氯氟烃的莫米松糠酸盐气雾剂配方

    公开(公告)号：US6068832A

    公开(公告)日：2000-05-30

    申请号：US920611

    申请日：1997-08-27

    申请人： Julianne Berry ,  Joel A. Sequeira ,  Imtiaz A. Chaudry

    发明人： Julianne Berry ,  Joel A. Sequeira ,  Imtiaz A. Chaudry

    IPC分类号： A61K9/00 ,  A61K31/58 ,  A61K9/12

    CPC分类号： A61K9/008 ,  A61K31/58

    摘要： The invention relates to suspension aerosol formulations which exhibit stable particle sizes, containing mometasone furoate, about 1 to about 10 weight percent ethanol and 1,1,1,2,3,3,3-Heptafluoropropane as the propellant. A surfactant, such as oleic acid, can also be included. These formulations are suitable for use in metered dose inhalers.

    摘要翻译： 本发明涉及悬浮气溶胶制剂，其表现出稳定的粒度，含有糠酸莫米他松，约1至约10重量％的乙醇和1,1,1,2,3,3,3-七氟丙烷作为推进剂。 还可以包括表面活性剂，例如油酸。 这些制剂适用于计量吸入器。

    Pharmaceutical Compositions
    9.
    发明申请
    Pharmaceutical Compositions 审中-公开
    药物组合物

    公开(公告)号：US20080064674A1

    公开(公告)日：2008-03-13

    申请号：US11940046

    申请日：2007-11-14

    申请人： Julianne Berry ,  Jill Sherwood ,  Saeed Chaudhry ,  Joel Sequeira

    发明人： Julianne Berry ,  Jill Sherwood ,  Saeed Chaudhry ,  Joel Sequeira

    IPC分类号： A61K31/56 ,  A61M11/00

    CPC分类号： A61K9/008 ,  A61K9/12 ,  A61K9/124 ,  A61K31/58 ,  A61K2300/00

    摘要： Disclosed are metered dose inhalers having a metering valve to deliver a dose containing an aerosol suspension formulation, said aerosol suspension formulation comprising: an effective amount of Mometasone Furoate, Formoterol or a combination thereof; a suspension medium selected from the group consisting of 1,1,1,2,3,3,3,-heptafluoropropane, 1,1,1,2-tetrafluoroethane; and a solvent that is ethanol; wherein said formulation contains less than about 500 μg of non-volatile residue as measured by ultraviolet spectroscopy.

    摘要翻译： 公开了具有计量阀以计量含有气溶胶悬浮液制剂的计量剂量吸入器，所述气溶胶悬浮液制剂包含：有效量的糠酸莫米松，福莫特罗或其组合; 选自1,1,1,2,3,3,3， - 七氟丙烷，1,1,1,2-四氟乙烷的悬浮介质; 和乙醇的溶剂; 其中所述制剂含有通过紫外光谱测量的小于约500杯非挥发性残余物。