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公开(公告)号：US08478402B2
公开(公告)日：2013-07-02
申请号：US12263346
申请日：2008-10-31
IPC分类号： A61N1/00
CPC分类号： A61B5/053 , A61B5/026 , A61B5/0538 , A61B5/6846 , A61B5/7217 , A61N1/36521
摘要： A system and method for determining complex intercardiac impedance to detect various cardiac functions are disclosed involving a signal generator means for providing an adjustable direct current signal, a modulator for modulating the adjustable direct current signal to produce a modulated signal, at least one electrode for propagating the modulated signal across a myocardium, at least one sensor for detecting an outputted modulated signal from the myocardium, and at least one circuit to reduce the influence of process noise (aggressors) in the outputted modulated signal. The at least one circuit comprises an amplifier, a demodulator, and an integrator. The amplitude and phase of the final outputted modulated signal indicate the complex impedance of the myocardium. Changes in the complex impedance patterns of the myocardium provide indication of reduced oxygen and blood flow to the myocardium. The apparatus can be employed in implantable devices, including cardiac pacemakers and implantable cardioverter defibrillators.
摘要翻译： 公开了一种用于确定复杂心脏阻抗以检测各种心脏功能的系统和方法，其涉及用于提供可调节直流电流信号的信号发生器装置，用于调制可调直流电信号以产生调制信号的调制器，用于传播的至少一个电极 跨越心肌的调制信号，用于检测来自心肌的输出的调制信号的至少一个传感器，以及至少一个电路，以减少输出的调制信号中的过程噪声（侵略者）的影响。 所述至少一个电路包括放大器，解调器和积分器。 最终输出的调制信号的振幅和相位表示心肌的复阻抗。 心肌复合阻抗模式的变化提供氧气和血液流向心肌的指示。 该装置可用于可植入装置，包括心脏起搏器和可植入的心律转复除颤器。
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公开(公告)号：US20100114223A1
公开(公告)日：2010-05-06
申请号：US12263346
申请日：2008-10-31
CPC分类号： A61B5/053 , A61B5/026 , A61B5/0538 , A61B5/6846 , A61B5/7217 , A61N1/36521
摘要： A system and method for determining complex intercardiac impedance to detect various cardiac functions are disclosed involving a signal generator means for providing an adjustable direct current signal, a modulator for modulating the adjustable direct current signal to produce a modulated signal, at least one electrode for propagating the modulated signal across a myocardium, at least one sensor for detecting an outputted modulated signal from the myocardium, and at least one circuit to reduce the influence of process noise (aggressors) in the outputted modulated signal. The at least one circuit comprises an amplifier, a demodulator, and an integrator. The amplitude and phase of the final outputted modulated signal indicate the complex impedance of the myocardium. Changes in the complex impedance patterns of the myocardium provide indication of reduced oxygen and blood flow to the myocardium. The apparatus can be employed in implantable devices, including cardiac pacemakers and implantable cardioverter defibrillators.
摘要翻译： 公开了一种用于确定复杂心脏阻抗以检测各种心脏功能的系统和方法，其涉及用于提供可调节直流电流信号的信号发生器装置，用于调制可调节直流电流信号以产生调制信号的调制器，用于传播的至少一个电极 跨越心肌的调制信号，用于检测来自心肌的输出的调制信号的至少一个传感器，以及至少一个电路，以减少输出的调制信号中的过程噪声（侵略者）的影响。 所述至少一个电路包括放大器，解调器和积分器。 最终输出的调制信号的振幅和相位表示心肌的复阻抗。 心肌复合阻抗模式的变化提供氧气和血液流向心肌的指示。 该装置可用于可植入装置，包括心脏起搏器和可植入的心律转复除颤器。
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公开(公告)号：US20100113964A1
公开(公告)日：2010-05-06
申请号：US12263358
申请日：2008-10-31
IPC分类号： A61B5/05
CPC分类号： A61B5/053 , A61B5/6846 , A61B5/7217
摘要： A system and method for determining complex intercardiac impedance to detect various cardiac functions are disclosed involving a signal generator means for providing an adjustable direct current signal, a modulator for modulating the adjustable direct current signal to produce a modulated signal, at least one electrode for propagating the modulated signal across a myocardium, at least one sensor for detecting an outputted modulated signal from the myocardium, and at least one circuit to reduce the influence of process noise (aggressors) in the outputted modulated signal. The at least one circuit comprises an amplifier, a demodulator, and an integrator. The amplitude and phase of the final outputted modulated signal indicate the complex impedance of the myocardium. Changes in the complex impedance patterns of the myocardium provide indication of reduced oxygen and blood flow to the myocardium. The apparatus can be employed in implantable devices, including cardiac pacemakers and implantable cardioverter defibrillators.
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公开(公告)号：US08463382B2
公开(公告)日：2013-06-11
申请号：US12868834
申请日：2010-08-26
申请人： David J. Jorgenson , Ross O. Starkson , Rick D. McVenes , Charles D. Trautmann , John D. Wahlstrand , Bradley C. Peck
发明人： David J. Jorgenson , Ross O. Starkson , Rick D. McVenes , Charles D. Trautmann , John D. Wahlstrand , Bradley C. Peck
IPC分类号： A61N1/365
CPC分类号： A61N1/3925 , A61N1/3706 , A61N2001/083
摘要： A system for monitoring trends in lead impedance includes collecting data from various sources in an implantable medical device system. Lead impedance, non-physiologic sensed events percentage of time in mode switch, results of capture management operation, sensed events, adversion pace counts, refractory sense counts and similar data are used to determine the status of a lead. A set of weighted sum rules are implemented by a software system to process the data and provide displayable information to health care professionals via a programmer. The lead monitoring system includes a patient alert system for patients to seek help in the event a serious lead condition is identified.
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5.发明授权Isolation circuitry and method for gradient field safety in an implantable medical device 有权可植入式医疗设备中梯度场安全的隔离电路和方法公开(公告)号：US08050763B2
公开(公告)日：2011-11-01
申请号：US12759228
申请日：2010-04-13
IPC分类号： A61N1/372
CPC分类号： A61N1/3752 , A61N1/3718
摘要： An implantable medical device is provided for isolating an elongated medical lead from internal device circuitry in the presence of a gradient magnetic or electrical field. The device includes an isolation circuit adapted to operatively connect an internal circuit to the medical lead in a first operative state and to electrically isolate the medical lead from the internal circuit in a second operative state.
摘要翻译： 提供了可植入医疗装置，用于在梯度磁场或电场的存在下将细长的医疗引线与内部装置电路隔离。 该装置包括隔离电路，其适于在第一操作状态下将内部电路可操作地连接到医疗引线，并且在第二操作状态下将医疗引线与内部电路电隔离。
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公开(公告)号：US06925331B2
公开(公告)日：2005-08-02
申请号：US10261314
申请日：2002-09-30
申请人： Kent E. Samuelson , Michael T. Hemming , Michael W. Heinks , Ross O. Starkson , Lori Durose-Schrimpf , John D. Wahlstrand
发明人： Kent E. Samuelson , Michael T. Hemming , Michael W. Heinks , Ross O. Starkson , Lori Durose-Schrimpf , John D. Wahlstrand
IPC分类号： A61B5/00 , A61B5/0402 , A61N1/372 , A61N1/365
CPC分类号： A61B5/0402 , A61B5/0006 , A61B5/7264 , A61N1/37247
摘要： A system and method for acquiring and processing an EGM signal during a pacing event, wherein a unique converter code is generated upon digitizing of the EGM signal and encrypted in the EGM signal to demarcate a transient event. The system further provides dynamic filtering of the EGM signal and subsequent detection of an intrinsic event signal during the pacing event, from which rhythm events may be diagnosed and classified.
摘要翻译： 一种用于在起搏事件期间获取和处理EGM信号的系统和方法，其中在EGM信号数字化并在EGM信号中加密以产生瞬时事件时产生唯一转换器代码。 该系统进一步提供EGM信号的动态滤波以及随后在起搏事件期间检测固有事件信号，从中可以诊断和分类节律事件。
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7.发明授权Apparatus and method to discriminate between telemetry downlink signals and noise in an implanted device 有权用于区分遥测下行链路信号和植入设备中的噪声的装置和方法公开(公告)号：US06788973B2
公开(公告)日：2004-09-07
申请号：US10117550
申请日：2002-04-02
IPC分类号： A61N137
CPC分类号： A61N1/37211 , A61N1/3718 , A61N1/37223 , A61N1/37276
摘要： An implanted medical device (IMD) conserves power by discriminating received radio frequency (RF) signals between noise and data based on frequency. Data is processed while noise is attenuated. The IMD operates in a first, relatively low, power mode while not receiving the RF signals, in a second, higher, power mode responsive to receiving RF signals, and operates in still higher power mode when the RF signals' average frequency over a selected period is within a predetermined range. A receiver circuit receives RF signals and discriminates a data signal from noise based on average frequency of the RF signals over selected time periods. The receiver circuit operates in a power-conserving mode unless it receives RF signals, or otherwise operates in a relatively higher-power mode. The receiver transfers signals to a telemetry circuit that operates in a power-conserving mode until it receives a valid data signal to operate in higher power mode.
摘要翻译： 植入式医疗设备（IMD）通过基于频率鉴别噪声和数据之间的接收射频（RF）信号来节省功率。 在噪声衰减时处理数据。 IMD在第一个相对较低的功率模式下工作，而不响应于接收RF信号而在第二较高功率模式中接收RF信号，并且当RF信号在所选择的频率上的平均频率 期间在预定范围内。 接收机电路接收RF信号，并根据选定时间段内的RF信号的平均频率，将数据信号与噪声区分开。 接收器电路在功率节省模式下工作，除非它接收RF信号，否则以较高功率模式工作。 接收机将信号传送到工作在省电模式的遥测电路，直到接收到有效的数据信号以在较高功率模式下工作。
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8.发明申请ISOLATION CIRCUITRY AND METHOD FOR GRADIENT FIELD SAFETY IN AN IMPLANTABLE MEDICAL DEVICE 有权分离电路和可移植医疗设备中梯度场安全的方法公开(公告)号：US20100198309A1
公开(公告)日：2010-08-05
申请号：US12759228
申请日：2010-04-13
IPC分类号： A61N1/08
CPC分类号： A61N1/3752 , A61N1/3718
摘要： An implantable medical device is provided for isolating an elongated medical lead from internal device circuitry in the presence of a gradient magnetic or electrical field. The device includes an isolation circuit adapted to operatively connect an internal circuit to the medical lead in a first operative state and to electrically isolate the medical lead from the internal circuit in a second operative state.
摘要翻译： 提供了可植入医疗装置，用于在梯度磁场或电场的存在下将细长的医疗引线与内部装置电路隔离。 该装置包括隔离电路，其适于在第一操作状态下将内部电路可操作地连接到医疗引线，并且在第二操作状态下将医疗引线与内部电路电隔离。
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公开(公告)号：US07031772B2
公开(公告)日：2006-04-18
申请号：US10134560
申请日：2002-04-29
申请人： Catherine R. Condie , John D. Wahlstrand , Gerald A. Portzline , Yong Kyun Cho , John S. Brandstetter , Luc R. Mongeon
发明人： Catherine R. Condie , John D. Wahlstrand , Gerald A. Portzline , Yong Kyun Cho , John S. Brandstetter , Luc R. Mongeon
IPC分类号： A61N1/365
CPC分类号： A61N1/36542 , A61N1/36521 , G06F19/00 , G06F19/3456 , G16H40/63
摘要： A method and an apparatus for performing rate responsive control in an implantable medical device using a scaling factor. Sensor data is acquired using a sensor operatively coupled with the implantable medical device. At least one setpoint for controlling a rate of therapy is generated, the setpoint being based upon the sensor data. A scaling factor adjustment process is performed for scaling the internal sensor data to correlate the sensor data to the setpoint. The rate of therapy is adjusted based upon the scaling factor adjustment.
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10.发明授权Implantable medical device for measuring time varying physiologic conditions especially edema and for responding thereto 有权用于测量时变生理条件的植入式医疗装置，特别是水肿并对其进行响应公开(公告)号：US06512949B1
公开(公告)日：2003-01-28
申请号：US09352179
申请日：1999-07-12
申请人： William J. Combs , Catherine R. Condie , Roy Martin , Dwight H. Warkentin , John D. Wahlstrand , David L. Thompson , Li Wang
发明人： William J. Combs , Catherine R. Condie , Roy Martin , Dwight H. Warkentin , John D. Wahlstrand , David L. Thompson , Li Wang
IPC分类号： A61B500
CPC分类号： A61N1/36521 , A61B5/0535 , A61B5/7207 , A61N1/3627
摘要： An impedance monitor for discerning edema through evaluation of respiratory rate. Preferred embodiment includes edema monitor and trigger to initiate diagnostic reporting or corrective action when activated. Recording of Long Term Average and Short Term Average values for secondary edema measure based on DC signal level are described as are methods and apparatus for removing unwanted recurring noise.
摘要翻译： 通过评估呼吸频率来辨别水肿的阻抗监测仪。 优选实施例包括水肿监测和触发以在被激活时启动诊断报告或纠正动作。 长期平均和短期记录基于直流信号电平的次级水肿测量的平均值被描述为用于消除不期望的重复噪声的方法和装置。
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