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1.发明授权Method and device for acquiring physiological data during tissue stimulation procedure 有权在组织刺激过程中获取生理数据的方法和装置公开(公告)号：US09399132B2
公开(公告)日：2016-07-26
申请号：US12825187
申请日：2010-06-28
CPC分类号： A61N1/08 , A61B5/04001 , A61B5/053 , A61B5/0538 , A61N1/0551 , A61N1/36071 , A61N1/36135 , A61N1/36164 , A61N1/37235
摘要： A method and system of providing therapy to a patient implanted with an array of electrodes is provided. A train of electrical stimulation pulses is conveyed within a stimulation timing channel between a group of the electrodes to stimulate neural tissue, thereby providing continuous therapy to the patient. Electrical parameter is sensed within a sensing timing channel using at least one of the electrodes, wherein the first stimulation timing channel and sensing timing channel are coordinated, such that the electrical parameter is sensed during the conveyance of the pulse train within time slots that do not temporally overlap any active phase of the stimulation pulses.
摘要翻译： 提供了向植入电极阵列的患者提供治疗的方法和系统。 一组电刺激脉冲在一组电极之间的刺激定时通道内传送以刺激神经组织，从而为患者提供持续的治疗。 使用至少一个电极在感测定时通道内感测电参数，其中协调第一激励定时通道和感测定时通道，使得在脉冲串的传送期间在不在的时隙内感测电参数 在时间上重叠刺激脉冲的任何活动相位。
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2.发明申请METHOD AND DEVICE FOR ACQUIRING PHYSIOLOGICAL DATA DURING TISSUE STIMULATION PROCEDURE 有权在组织刺激过程中获取生理数据的方法和装置公开(公告)号：US20100331916A1
公开(公告)日：2010-12-30
申请号：US12825187
申请日：2010-06-28
CPC分类号： A61N1/08 , A61B5/04001 , A61B5/053 , A61B5/0538 , A61N1/0551 , A61N1/36071 , A61N1/36135 , A61N1/36164 , A61N1/37235
摘要： A method and system of providing therapy to a patient implanted with an array of electrodes is provided. A train of electrical stimulation pulses is conveyed within a stimulation timing channel between a group of the electrodes to stimulate neural tissue, thereby providing continuous therapy to the patient. Electrical parameter is sensed within a sensing timing channel using at least one of the electrodes, wherein the first stimulation timing channel and sensing timing channel are coordinated, such that the electrical parameter is sensed during the conveyance of the pulse train within time slots that do not temporally overlap any active phase of the stimulation pulses.
摘要翻译： 提供了向植入电极阵列的患者提供治疗的方法和系统。 一组电刺激脉冲在一组电极之间的刺激定时通道内传送以刺激神经组织，从而为患者提供持续的治疗。 使用至少一个电极在感测定时通道内感测电参数，其中协调第一激励定时通道和感测定时通道，使得在脉冲串的传送期间在不在的时隙内感测电参数 在时间上重叠刺激脉冲的任何活动相位。
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3.发明授权Multi-electrode implantable stimulator device with a single current path decoupling capacitor 有权具有单电流路径去耦电容器的多电极可植入刺激装置公开(公告)号：US07881803B2
公开(公告)日：2011-02-01
申请号：US11550655
申请日：2006-10-18
申请人： Jordi Parramon , Kiran Nimmagadda , Emanuel Feldman , Yuping He
发明人： Jordi Parramon , Kiran Nimmagadda , Emanuel Feldman , Yuping He
IPC分类号： A61N1/40
CPC分类号： A61N1/36125 , A61N1/025 , A61N1/08 , A61N1/372 , A61N1/37205 , A61N1/3756
摘要： Disclosed herein are circuits and methods for a multi-electrode implantable stimulator device incorporating one decoupling capacitor in the current path established via at least one cathode electrode and at least one anode electrode. In one embodiment, the decoupling capacitor may be hard-wired to a dedicated anode on the device. The cathodes are selectively activatable via stimulation switches. In another embodiment, any of the electrodes on the devices can be selectively activatable as an anode or cathode. In this embodiment, the decoupling capacitor is placed into the current path via selectable anode and cathode stimulation switches. Regardless of the implementation, the techniques allow for the benefits of capacitive decoupling without the need to associate decoupling capacitors with every electrode on the multi-electrode device, which saves space in the body of the device. Although of particular benefit when applied to microstimulators, the disclosed technique can be used with space-saving benefits in any stimulator device.
摘要翻译： 本文公开了用于在经由至少一个阴极电极和至少一个阳极电极建立的电流路径中并入一个去耦电容器的多电极可植入刺激器装置的电路和方法。 在一个实施例中，去耦电容器可以硬连接到器件上的专用阳极。 阴极可以通过刺激开关选择性地激活。 在另一个实施例中，器件上的任何电极可以选择性地激活为阳极或阴极。 在该实施例中，去耦电容通过可选择的阳极和阴极刺激开关放置在电流路径中。 不管实施方案如何，这些技术允许电容去耦的优点，而不需要将去耦电容器与多电极器件上的每个电极相关联，这节省了器件体内的空间。 虽然在应用于微型激励器时特别有益，但是所公开的技术可以在任何刺激器装置中具有节省空间的优点。
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4.发明授权公开(公告)号：US08577474B2
公开(公告)日：2013-11-05
申请号：US12616178
申请日：2009-11-11
CPC分类号： A61N1/37217 , A61N1/3718 , A61N1/37211 , A61N1/37229 , A61N1/3758 , A61N1/3787
摘要： An improved implantable pulse generator (IPG) containing improved telemetry circuitry is disclosed. The IPG includes charging and telemetry coils within the IPG case, which increases their mutual inductance and potential to interfere with each other; particularly problematic is interference to the telemetry coil caused by the charging coil. To combat this, improved telemetry circuitry includes decoupling circuitry for decoupling the charging coil during periods of telemetry between the IPG and an external controller. Such decoupling circuitry can comprise use of pre-existing LSK circuitry during telemetry, or new discrete circuitry dedicated to decoupling. The decoupling circuitry is designed to prevent or at least reduce induced current flowing through the charging coil during data telemetry. The decoupling circuitry can be controlled by the microcontroller in the IPG, or can automatically decouple the charging coil at appropriate times to mitigate an induced current without instruction from the microcontroller.
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5.发明授权Ultracapacitor powered implantable pulse generator with dedicated power supply 有权具有专用电源的超级电容器动力植入脉冲发生器公开(公告)号：US08175717B2
公开(公告)日：2012-05-08
申请号：US11221095
申请日：2005-09-06
IPC分类号： A61N1/00
CPC分类号： A61N1/3787 , A61N1/37247 , A61N1/37258 , A61N1/37264
摘要： A stimulator includes an implantable pulse generator comprising circuit elements, a first power source, such as an ultracapacitor, that provides operating power for the circuit elements of the pulse generator. The pulse generator can also have a memory associated therewith, such as a volatile memory for storing programming data. A second power source that has higher voltage retention than the first power source can also be included. The second power source can be dedicated to the volatile memory and can provide operating power for the volatile memory.
摘要翻译： 刺激器包括可植入脉冲发生器，其包括电路元件，第一电源，例如超级电容器，其为脉冲发生器的电路元件提供工作电力。 脉冲发生器还可以具有与其相关联的存储器，诸如用于存储编程数据的易失性存储器。 还可以包括比第一电源具有更高的电压保持的第二电源。 第二个电源可以专用于易失性存储器，并且可以为易失性存储器提供工作电源。
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6.发明申请Monitoring Electrode Voltages in an Implantable Medical Device System Having Daisy-Chained Electrode-Driver Integrated Circuits 有权在具有菊花链电极驱动器集成电路的可植入医疗设备系统中监测电极电压公开(公告)号：US20120095519A1
公开(公告)日：2012-04-19
申请号：US13237531
申请日：2011-09-20
申请人： Jordi Parramon , Jess W. Shi , Emanuel Feldman
发明人： Jordi Parramon , Jess W. Shi , Emanuel Feldman
IPC分类号： A61N1/372
CPC分类号： A61N1/37241 , A61N1/025 , A61N1/05 , A61N1/0551 , A61N1/08 , A61N1/3605 , A61N1/36125 , A61N1/36153
摘要： Electrode voltage monitoring circuitry for an implantable neurostimulator system having a plurality of electrode-driver integrated circuits (ICs) in provided. Electrodes from either or both ICs can be chosen to provide stimulation, and one of the IC acts as the master while the other acts as the slave. Electrodes voltages on the slave IC are routed to the master IC, and thus the master IC can monitor both electrode voltages on the slave as well as electrode voltages on the master. Such voltages can be monitored for a variety of purposes, and in particular use of such voltage is disclosed for determining the resistance between electrodes and to set a compliance voltage for stimulation.
摘要翻译： 一种具有多个电极驱动器集成电路（IC）的可植入神经刺激器系统的电极电压监视电路。 可以选择来自任一个或两个IC的电极以提供刺激，并且IC中的一个用作主器件，而另一个用作从器件。 从IC上的电极电压被路由到主IC，因此主IC可以监控从站上的两个电极电压以及主站上的电极电压。 为了各种目的可以监测这样的电压，并且特别地使用这种电压来确定电极之间的电阻并设置用于刺激的顺应性电压。
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公开(公告)号：US20080319497A1
公开(公告)日：2008-12-25
申请号：US11767636
申请日：2007-06-25
申请人： Paul J. Griffith , Jordi Parramon , Goran N. Marnfeldt , Daniel Aghassian , Kiran Nimmagadda , Emanuel Feldman , Jess W. Shi
发明人： Paul J. Griffith , Jordi Parramon , Goran N. Marnfeldt , Daniel Aghassian , Kiran Nimmagadda , Emanuel Feldman , Jess W. Shi
IPC分类号： A61N1/08
CPC分类号： A61N1/36125 , A61N1/025 , A61N1/0551 , A61N1/0553 , A61N1/36071
摘要： An improved architecture for an implantable medical device such as an implantable pulse generator (IPG) is disclosed. In one embodiment, the various functional blocks for the IPG are incorporated into a signal integrated circuit (IC). Each of the functional blocks communicate with each other, and with other off-chip devices if necessary, via a centralized bus governed by a communication protocol. To communicate with the bus and to adhere to the protocol, each circuit block includes bus interface circuitry adherent with that protocol. Because each block complies with the protocol, any given block can easily be modified or upgraded without affecting the design of the other blocks, facilitating debugging and upgrading of the IPG circuitry. Moreover, because the centralized bus can be taken off the integrated circuit, extra circuitry can easily be added off chip to modify or add functionality to the IPG without the need for a major redesign of the main IPG IC.
摘要翻译： 公开了一种用于植入式医疗装置（例如植入式脉冲发生器（IPG））的改进的架构。 在一个实施例中，用于IPG的各种功能块被并入到信号集成电路（IC）中。 每个功能块通过由通信协议管理的集中式总线彼此通信，并且如果需要，与其他片外设备通信。 为了与总线进行通信并遵守协议，每个电路块包括与该协议相关的总线接口电路。 由于每个块符合协议，任何给定的块都可以轻松修改或升级，而不影响其他块的设计，便于IPG电路的调试和升级。 此外，由于集中式总线可以从集成电路中取出，所以额外的电路可以轻松地从芯片上添加到IPG中，以便对IPG进行主要的重新设计。
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8.发明申请Multi-Electrode Implantable Stimulator Device with a Single Current Path Decoupling Capacitor 有权具有单电流路径去耦电容器的多电极植入式刺激器装置公开(公告)号：US20080097529A1
公开(公告)日：2008-04-24
申请号：US11550655
申请日：2006-10-18
申请人： Jordi Parramon , Kiran Nimmagadda , Emanuel Feldman , Yuping He
发明人： Jordi Parramon , Kiran Nimmagadda , Emanuel Feldman , Yuping He
IPC分类号： A61N1/00
CPC分类号： A61N1/36125 , A61N1/025 , A61N1/08 , A61N1/372 , A61N1/37205 , A61N1/3756
摘要： Disclosed herein are circuits and methods for a multi-electrode implantable stimulator device incorporating one decoupling capacitor in the current path established via at least one cathode electrode and at least one anode electrode. In one embodiment, the decoupling capacitor may be hard-wired to a dedicated anode on the device. The cathodes are selectively activatable via stimulation switches. In another embodiment, any of the electrodes on the devices can be selectively activatable as an anode or cathode. In this embodiment, the decoupling capacitor is placed into the current path via selectable anode and cathode stimulation switches. Regardless of the implementation, the techniques allow for the benefits of capacitive decoupling without the need to associate decoupling capacitors with every electrode on the multi-electrode device, which saves space in the body of the device. Although of particular benefit when applied to microstimulators, the disclosed technique can be used with space-saving benefits in any stimulator device.
摘要翻译： 本文公开了用于在经由至少一个阴极电极和至少一个阳极电极建立的电流路径中并入一个去耦电容器的多电极可植入刺激器装置的电路和方法。 在一个实施例中，去耦电容器可以硬连接到器件上的专用阳极。 阴极可以通过刺激开关选择性地激活。 在另一个实施例中，器件上的任何电极可以选择性地激活为阳极或阴极。 在该实施例中，去耦电容通过可选择的阳极和阴极刺激开关放置在电流路径中。 不管实施方案如何，这些技术允许电容去耦的优点，而不需要将去耦电容器与多电极器件上的每个电极相关联，这节省了器件体内的空间。 虽然在应用于微型激励器时特别有益，但是所公开的技术可以在任何刺激器装置中具有节省空间的优点。
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公开(公告)号：US09393433B2
公开(公告)日：2016-07-19
申请号：US13489770
申请日：2012-06-06
发明人： Jordi Parramon , Goran N. Marnfeldt , Robert Ozawa , Emanuel Feldman , Dave Peterson , Yuping He
CPC分类号： A61N1/3787 , A61N1/08
摘要： Battery management circuitry for an implantable medical device such as an implantable neurostimulator is described. The circuitry has a T-shape with respect to the battery terminal, with charging circuitry coupled between rectifier circuitry and the battery terminal on one side of the T, and load isolation circuitry coupled between the load and the battery terminal on the other side. The load isolation circuitry can comprise two switches wired in parallel. An undervoltage fault condition opens both switches to isolate the battery terminal from the load to prevent further dissipation of the battery. Other fault conditions will open only one the switches leaving the other closed to allow for reduced power to the load to continue implant operations albeit at safer low-power levels. The battery management circuitry can be fixed in a particular location on an integrated circuit which also includes for example the stimulation circuitry for the electrodes.
摘要翻译： 描述了诸如可植入神经刺激器的可植入医疗装置的电池管理电路。 电路相对于电池端子具有T形，充电电路耦合在整流器电路和T的一侧上的电池端子之间，负载隔离电路耦合在另一侧的负载和电池端子之间。 负载隔离电路可以包括并联的两个开关。 欠压故障条件打开两个开关以将电池端子与负载隔离，以防止电池进一步耗散。 其他故障条件将仅打开一个开关，使另一个闭合，以允许降低负载的功率，以继续进行种植体操作，尽管处于更安全的低功率水平。 电池管理电路可以固定在集成电路的特定位置，该集成电路还包括例如用于电极的刺激电路。
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10.发明授权Monitoring electrode voltages in an implantable medical device system having daisy-chained electrode-driver integrated circuits 有权在具有菊花链电极驱动器集成电路的可植入医疗装置系统中监测电极电压公开(公告)号：US08768453B2
公开(公告)日：2014-07-01
申请号：US13237531
申请日：2011-09-20
申请人： Jordi Parramon , Jess W. Shi , Emanuel Feldman
发明人： Jordi Parramon , Jess W. Shi , Emanuel Feldman
IPC分类号： A61N1/08
CPC分类号： A61N1/37241 , A61N1/025 , A61N1/05 , A61N1/0551 , A61N1/08 , A61N1/3605 , A61N1/36125 , A61N1/36153
摘要： Electrode voltage monitoring circuitry for an implantable neurostimulator system having a plurality of electrode-driver integrated circuits (ICs) in provided. Electrodes from either or both ICs can be chosen to provide stimulation, and one of the IC acts as the master while the other acts as the slave. Electrodes voltages on the slave IC are routed to the master IC, and thus the master IC can monitor both electrode voltages on the slave as well as electrode voltages on the master. Such voltages can be monitored for a variety of purposes, and in particular use of such voltage is disclosed for determining the resistance between electrodes and to set a compliance voltage for stimulation.
摘要翻译： 一种具有多个电极驱动器集成电路（IC）的可植入神经刺激器系统的电极电压监视电路。 可以选择来自任一个或两个IC的电极以提供刺激，并且IC中的一个用作主器件，而另一个用作从器件。 从IC上的电极电压被路由到主IC，因此主IC可以监控从站上的两个电极电压以及主站上的电极电压。 为了各种目的可以监测这样的电压，并且特别地使用这种电压来确定电极之间的电阻并设置用于刺激的顺应性电压。
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