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公开(公告)号：US20130165441A1
公开(公告)日：2013-06-27
申请号：US13821585
申请日：2011-09-06
申请人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr , Robert David Willacy
发明人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr , Robert David Willacy
IPC分类号： C07D413/14
CPC分类号： A61K31/5377 , C07D413/14
摘要： The present invention is directed to novel polymorphs and salts of a compound which is an inhibitor of kinase activity.
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公开(公告)号：US08735390B2
公开(公告)日：2014-05-27
申请号：US13821585
申请日：2011-09-06
申请人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr , Robert David Willacy
发明人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr , Robert David Willacy
IPC分类号： A61K31/5377 , C07D413/14
CPC分类号： A61K31/5377 , C07D413/14
摘要： The present invention is directed to novel polymorphs and salts of a compound which is an inhibitor of kinase activity.
摘要翻译： 本发明涉及作为激酶活性抑制剂的化合物的新型多晶型物和盐。
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公开(公告)号：US08609657B2
公开(公告)日：2013-12-17
申请号：US13633230
申请日：2012-10-02
申请人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr
发明人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/535 , A61K45/06 , C07B2200/13 , C07D413/14 , Y02A50/409
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
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公开(公告)号：US20130165433A1
公开(公告)日：2013-06-27
申请号：US13821594
申请日：2011-09-06
申请人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Zoe Alicia Harrison , Katherine Louise Jones , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Christopher James Lunniss , Charlotte Jane Mitchell , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christopher Alan Paul Smethurst , Yoshiaki Washio
发明人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Zoe Alicia Harrison , Katherine Louise Jones , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Christopher James Lunniss , Charlotte Jane Mitchell , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christopher Alan Paul Smethurst , Yoshiaki Washio
IPC分类号： C07D413/14
CPC分类号： A61K31/5377 , A61K31/416 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5386 , C07D413/14
摘要： The present invention is directed to compounds for use in the treatment or prevention of influenza virus infection.
摘要翻译： 本发明涉及用于治疗或预防流感病毒感染的化合物。
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5.发明授权公开(公告)号：US09326987B2
公开(公告)日：2016-05-03
申请号：US13821594
申请日：2011-09-06
申请人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr
发明人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr
IPC分类号： A61K31/535 , A61K31/497 , A61K31/445 , A61K31/55 , A61K31/5377 , C07D413/14 , A61K31/416 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5386
CPC分类号： A61K31/5377 , A61K31/416 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5386 , C07D413/14
摘要： The present invention is directed to compounds for use in the treatment or prevention of influenza virus infection.
摘要翻译： 本发明涉及用于治疗或预防流感病毒感染的化合物。
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公开(公告)号：US08575162B2
公开(公告)日：2013-11-05
申请号：US12768775
申请日：2010-04-28
申请人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr
发明人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/535 , A61K45/06 , C07B2200/13 , C07D413/14 , Y02A50/409
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
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公开(公告)号：US20120046286A1
公开(公告)日：2012-02-23
申请号：US13266254
申请日：2010-04-28
申请人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr
发明人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr
IPC分类号： A61K31/5377 , A61K31/496 , A61P11/00 , A61P31/12 , A61P37/08 , A61P29/00 , A61P9/00 , A61P7/00 , A61P25/00 , A61P1/18 , A61P13/12 , A61P11/06 , A61P33/02 , A61P31/10 , A61P19/02 , A61P9/10 , A61P7/02 , A61P35/00 , A61P25/04 , C07D413/14
CPC分类号： A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/535 , A61K45/06 , C07B2200/13 , C07D413/14 , Y02A50/409
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): And salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
摘要翻译： 本发明涉及某些新化合物。 具体地，本发明涉及式（I）的化合物及其盐。 本发明的化合物是激酶活性的抑制剂，特别是PI3-激酶活性。
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公开(公告)号：US20100280029A1
公开(公告)日：2010-11-04
申请号：US12768775
申请日：2010-04-28
申请人： Julie Nicole HAMBLIN , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr
发明人： Julie Nicole HAMBLIN , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr
IPC分类号： A61K31/5377 , C07D413/14 , A61P11/00 , A61P31/12 , A61P37/08 , A61P37/00 , A61P29/00 , A61P9/00 , A61P25/00 , A61P35/00
CPC分类号： A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/535 , A61K45/06 , C07B2200/13 , C07D413/14 , Y02A50/409
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
摘要翻译： 本发明涉及某些新化合物。 具体地，本发明涉及式（I）的化合物及其盐。 本发明的化合物是激酶活性的抑制剂，特别是PI3-激酶活性。
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![6-(1H-indol-4-yl)-4-(5-{[4-1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazole hemi succinate salt, polymorphs and pharmaceutical compositions thereof](/abs-image/US/2015/03/31/US08993576B2/abs.jpg.150x150.jpg)
9.发明授权6-(1H-indol-4-yl)-4-(5-{[4-1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazole hemi succinate salt, polymorphs and pharmaceutical compositions thereof 有权6-（1H-吲哚-4-基）-4-（5 - {[4-1-甲基乙基] -1-哌嗪基]甲基} -1,3-恶唑-2-基）-1H-吲唑半琥珀酸盐 ，多晶型物及其药物组合物公开(公告)号：US08993576B2
公开(公告)日：2015-03-31
申请号：US13879667
申请日：2011-10-25
申请人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr , Robert David Willacy
发明人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr , Robert David Willacy
IPC分类号： A61K31/496 , C07D413/14
CPC分类号： C07D413/14
摘要： The present invention is directed to a polymorph of a compound and salts of a compound and polymorphs thereof, which compound is an inhibitor of kinase activity.
摘要翻译： 本发明涉及一种化合物和化合物的盐及其多晶型物的多晶型物，该化合物是激酶活性的抑制剂。
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公开(公告)号：US20130203772A1
公开(公告)日：2013-08-08
申请号：US13879667
申请日：2011-10-25
申请人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr , Robert David Willacy
发明人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr , Robert David Willacy
IPC分类号： C07D413/14
CPC分类号： C07D413/14
摘要： The present invention is directed to a polymorph of a compound and salts of a compound and polymorphs thereof, which compound is an inhibitor of kinase activity.
摘要翻译： 本发明涉及一种化合物和化合物的盐及其多晶型物的多晶型物，该化合物是激酶活性的抑制剂。
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