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1.发明授权公开(公告)号：US11066475B2
公开(公告)日：2021-07-20
申请号：US16178571
申请日：2018-11-01
发明人： Blythe D. Sather , Eric L. Smith , Rupesh Amin , Aye Chen , Kimberly Harrington , Collin Hauskins , Erik Hess , Cyr De Imus , Jon Jones , Audrey Olshefsky , Stefan Ponko , Ruth Salmon , Semih Tareen , Rebecca Wu , Yan Chen , Steven M. Shamah , Csaba Pazmany , Jui Dutta-Simmons , Mariana Cota Stirner , Melissa Works
IPC分类号： A61K35/17 , C07K16/28 , C07K14/725 , A61P35/00 , A61K39/395 , C07K14/705 , C12Q1/6848 , A61K39/00 , A61K38/00
摘要： Provided herein are chimeric receptors, such as chimeric antigen receptors (CARs), comprising BCMA-binding molecules, such as anti-BCMA antibodies and antigen-binding fragments thereof, such as heavy chain variable (VH) regions and single-chain antibody fragments, and encoding polynucleotides. In some embodiments, the anti-BCMA chimeric receptors specifically bind to BCMA. Among the anti-BCMA-binding molecules are human antibodies, including those that compete for binding to BCMA with reference antibodies, such as a non-human reference antibody. Also provided are genetically engineered cells expressing the CARs and uses thereof such as in adoptive cell therapy.
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2.发明公开公开(公告)号：US20240091257A1
公开(公告)日：2024-03-21
申请号：US18039660
申请日：2021-12-10
发明人： Ivan M. Borrello , Amy Thomas , Eric L. Smith
IPC分类号： A61K35/17 , C07K16/28 , C12N5/0783
CPC分类号： A61K35/17 , C07K16/2809 , C07K16/2818 , C07K16/2878 , C12N5/0636 , C07K2317/31 , C12N2501/51 , C12N2501/515
摘要： Provided herein are methods of treatment including methods of treating cancer and methods of enhancing an anti-tumoral activity of a bispecific T-cell engager (BiTE) or of a bispecific antibody. The methods disclosed herein include activating T-cells and contacting activated T-cells with BiTEs or bispecific antibodies for administration to a subject.
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3.发明申请公开(公告)号：US20210346432A1
公开(公告)日：2021-11-11
申请号：US17228213
申请日：2021-04-12
发明人： Renier J. Brentjens , Eric L. Smith , Cheng Liu
IPC分类号： A61K35/17 , C07K16/28 , C07K14/705 , C07K14/725 , A61P35/00
摘要： The presently disclosed subject matter provides for methods and compositions for treating multiple myeloma. It relates to chimeric antigen receptors (CARs) that specifically target B cell maturation antigen (BCMA), and immunoresponsive cells comprising such CARs. The presently disclosed BCMA-specific CARs have enhanced immune-activating properties, including anti-tumor activity.
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公开(公告)号：US10821135B2
公开(公告)日：2020-11-03
申请号：US16844759
申请日：2020-04-09
发明人： Renier J. Brentjens , Eric L. Smith , Cheng Liu
IPC分类号： C07K16/28 , C07K14/705 , A61K35/17 , C07K14/725 , A61P35/00
摘要： The presently disclosed subject matter provides for methods and compositions for treating multiple myeloma. It relates to chimeric antigen receptors (CARs) that specifically target B cell maturation antigen (BMCA), and immunoresponsive cells comprising such CARs. The presently disclosed BMCA-specific CARs have enhanced immune-activating properties, including anti-tumor activity.
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5.发明申请公开(公告)号：US20200270328A1
公开(公告)日：2020-08-27
申请号：US16798151
申请日：2020-02-21
发明人： Renier J. Brentjens , Eric L. Smith , Cheng Liu
IPC分类号： C07K14/725 , C07K16/28
摘要： The presently disclosed subject matter provides for methods and compositions for treating multiple myeloma. It relates to chimeric antigen receptors (CARs) that specifically target a G-protein coupled receptor (e.g., a G-protein coupled receptor family C group 5 member D (GPRC5D)), and immunoresponsive cells comprising such CARs. The presently disclosed CARs targeting a G-protein coupled receptor (e.g., GPRC5D) have enhanced immune-activating properties, including anti-tumor activity.
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公开(公告)号：US20180118822A1
公开(公告)日：2018-05-03
申请号：US15614290
申请日：2017-06-05
发明人： Renier J. Brentjens , Eric L. Smith , Cheng Liu
CPC分类号： C07K16/28 , A61K47/6849 , A61P35/00 , C07K16/2809 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/622 , C07K2317/92 , C07K2319/21 , G01N33/6872 , G01N2333/705
摘要： The presently disclosed subject matter provides antibodies that bind to GPRC5D and methods of using the same.
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公开(公告)号：US20210388081A1
公开(公告)日：2021-12-16
申请号：US17143833
申请日：2021-01-07
发明人： Renier J. Brentjens , Eric L. Smith , Cheng Liu
IPC分类号： C07K16/28 , A61K47/64 , A61K47/68 , A61P35/00 , A61K39/395
摘要： The presently disclosed subject matter provides fully human antibodies or antigen-binding fragments thereof that bind to FcRL5 and methods of using the same.
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公开(公告)号：US10947314B2
公开(公告)日：2021-03-16
申请号：US16732089
申请日：2019-12-31
发明人： Renier J. Brentjens , Eric L. Smith , Cheng Liu
摘要： The presently disclosed subject matter provides antibodies that bind to B-cell maturation antigen (BCMA) and methods of using the same.
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公开(公告)号：US10590196B2
公开(公告)日：2020-03-17
申请号：US15614290
申请日：2017-06-05
发明人： Renier J. Brentjens , Eric L. Smith , Cheng Liu
摘要： The presently disclosed subject matter provides antibodies that bind to GPRC5D and methods of using the same.
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公开(公告)号：US20180371085A1
公开(公告)日：2018-12-27
申请号：US15997155
申请日：2018-06-04
发明人： Renier J. Brentjens , Eric L. Smith , Cheng Liu
IPC分类号： C07K16/28 , A61P35/00 , A61K47/68 , A61K47/64 , A61K39/395
摘要： The presently disclosed subject matter provides fully human antibodies or antigen-binding fragments thereof that bind to FcRL5 and methods of using the same.
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