公开(公告)号：US20190144404A1

公开(公告)日：2019-05-16

申请号：US16244824

申请日：2019-01-10

Applicant: KANEKA CORPORATION

Inventor： Hiroaki YASUKOUCHI ,  Masaru MITSUDA ,  Akira NISHIYAMA ,  Makoto FUNABASHI

IPC: C07D301/00 ,  C07C67/14 ,  C07C231/02 ,  C07D263/44 ,  C07D471/08 ,  C07D217/06

Abstract: The present disclosure provides a reaction of a chlorine-containing compound using a flow reactor which is less restricted by a solvent to be used. In the present disclosure, an organic compound is produced by supplying a reaction substrate having at least one functional group which can react with chlorine and is selected from the group consisting of hydroxy group, a thiol group, an amino group, a carboxyl group, a thiocarboxyl group, and an acid amide group, and a chlorine-containing compound to a flow reactor together with a trialkyl amine having 9 to 40 carbon atoms and an organic solvent, and allowing the reaction substrate and the chlorine-containing compound to react with each other.

公开(公告)号：US20190177262A1

公开(公告)日：2019-06-13

申请号：US16244850

申请日：2019-01-10

Applicant: KANEKA CORPORATION

Inventor： Hiroaki YASUKOUCHI ,  Makoto FUNABASHI ,  Akira NISHIYAMA ,  Toshihiro TAKEDA ,  Masaru MITSUDA

IPC: C07C68/02

Abstract: The present invention provides a method for safely producing a large amount of chloroformate compound with high yield. The chloroformate compound can be produced by mixing and reacting a solution of triphosgene, an amine and an alcohol compound in a flow reactor. The chloroformate compound can also be produced by mixing and reacting a solution of triphosgene with a solution comprising an amine and an alcohol compound in a flow reactor. The amine is preferably tributylamine, and preferably used in an amount of 0.8 to 3 equivalents relative to an amount of the alcohol compound.

公开(公告)号：US20140288268A1

公开(公告)日：2014-09-25

申请号：US14204074

申请日：2014-03-11

Applicant: KANEKA CORPORATION

Inventor： Hiroshi MURAO ,  Ken-ichiro MORIO ,  Masaru MITSUDA

IPC: C07K1/06 ,  C07K1/14

CPC classification number: C07K1/061 ,  C07K1/02 ,  C07K1/14 ,  C07K5/06078 ,  C07K5/06095 ,  C07K5/0806 ,  C07K5/0808 ,  C07K5/101

Abstract: The present invention is related to a method of producing a peptide, characterized in contacting a reaction mixture with a base after a condensation reaction to hydrolyze while a basic condition is maintained until a ratio of a remaining unreacted active ester of an acid component is decreased to 1% or less in a liquid phase peptide synthesis method. According to the invention, a target peptide of high purity can be simply and efficiently produced by a continuous liquid phase synthesis method. Further, the present invention is related to a method of producing a peptide, characterized in using an amide-type solvent immiscible with water in a liquid phase peptide synthesis method. According to the invention, various peptides can be produced by the liquid phase synthesis method without being restricted by the amino acid sequence of the target peptide.

Abstract translation: 本发明涉及一种生产肽的方法，其特征在于在缩合反应之后将反应混合物与碱反应以在碱性条件保持下进行水解，直到酸组分的剩余未反应的活性酯的比例降低至 在液相肽合成方法中为1％以下。 根据本发明，可以通过连续液相合成法简单有效地制备高纯度的靶肽。 此外，本发明涉及一种制备肽的方法，其特征在于在液相肽合成方法中使用与水不混溶的酰胺型溶剂。 根据本发明，可以通过液相合成法制备各种肽，而不受目标肽的氨基酸序列的限制。