公开(公告)号：US09458120B2

公开(公告)日：2016-10-04

申请号：US14361844

申请日：2012-11-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eun-Joo Roh ,  Kye-Jung Shin ,  Changjoon Justin Lee ,  Soo Jin Oh ,  Jung-Eun Park ,  Jeong Eun Yang ,  Eun Mi Hwang ,  Dong Ho Woo ,  Soon-Hyouk Lee ,  Dong-Gyu Kim ,  Hee-jung Chun ,  Wan-Keun Ji ,  Yun-Soo Na

IPC: C07D295/15 ,  A61K31/496 ,  C07D295/088 ,  C07D231/40 ,  C07D211/22 ,  C07D211/38 ,  C07D211/52 ,  C07D211/58 ,  C07D233/64 ,  C12N5/071 ,  C07D401/04 ,  C07D403/06 ,  C07D413/04 ,  A61K31/495 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5377

CPC classification number: C07D295/15 ,  C07D211/22 ,  C07D211/38 ,  C07D211/52 ,  C07D211/58 ,  C07D231/40 ,  C07D233/64 ,  C07D295/088 ,  C12N5/0686 ,  C12N2501/999

Abstract: The present invention relates to a novel phenoxypropanol derivative, represented by the structure of Chemical Formula I, and a racemate thereof, a pharmaceutically acceptable salt thereof, a solvate thereof and a hydrate thereof, wherein * represents an (R)-form or an (S)-form, X is selected from the group consisting of hydrogen, halogen and substituted or unsubstituted straight or branched alkyl having 1 to 4 carbon atoms, and n represents the number of X and an integer of 1 to 5, wherein at least a hydrogen is substituted with halogen in the substituted linear or branched alkyl having 1 to 4 carbon atoms. The derivative can be used for blocking T-type calcium channel and/or TREK channel, and for preventing and/or treating T-type calcium channel- and/or TREK channel-associated diseases.

Abstract translation: 其中*表示（R） - 型或（S） - 型，X选自氢，卤素和具有1至4个碳原子的取代或未取代的直链或支链烷基，n表示X 和1〜5的整数，其中在具有1〜4个碳原子的取代的直链或支链烷基中至少有一个氢被卤素取代。 该衍生物可用于阻断T型钙通道和/或TREK通道，以及用于预防和/或治疗T型钙通道和/或TREK通道相关疾病。

公开(公告)号：US20150166496A1

公开(公告)日：2015-06-18

申请号：US14361844

申请日：2012-11-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eun-Joo Roh ,  Kye-Jung Shin ,  Changjoon Justin Lee ,  Soo Jin Oh ,  Jung-Eun Park ,  Jeong Eun Yang ,  Eun Mi Hwang ,  Dong Ho Woo ,  Soon-Hyouk Lee ,  Dong-Gyu Kim ,  Hee-jung Chun ,  Wan-Keun Ji ,  Yun-Soo Na

IPC: C07D295/15 ,  C07D233/64 ,  C12N5/071 ,  C07D211/58 ,  C07D211/52 ,  C07D295/088 ,  C07D211/22

CPC classification number: C07D295/15 ,  C07D211/22 ,  C07D211/38 ,  C07D211/52 ,  C07D211/58 ,  C07D231/40 ,  C07D233/64 ,  C07D295/088 ,  C12N5/0686 ,  C12N2501/999

Abstract: The present invention relates to a novel phenoxypropanol derivative, use thereof for blocking T-type calcium channel and/or TREK channel, and use thereof for preventing and/or treating T-type calcium channel- and/or TREK channel-associated diseases.

Abstract translation: 本发明涉及新的苯氧基丙醇衍生物，其用于阻断T型钙通道和/或TREK通道的用途及其用于预防和/或治疗T型钙通道和/或TREK通道相关疾病的用途。

公开(公告)号：US20130150384A1

公开(公告)日：2013-06-13

申请号：US13768022

申请日：2013-02-15

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Justin Changjoon LEE ,  Eun-Joo Roh ,  Jin-Kyu Choi ,  Kyung-Suk Han ,  Jung-Eun Park ,  Sang-Soo Kang ,  Bo Mi Ku ,  Yeon Kyung Lee ,  Antoine G. Almonte ,  Dongho Woo ,  Jung-Hwan Park ,  Seon Ha Paek

IPC: A61K31/522

CPC classification number: A61K31/522

Abstract: A method for preventing and/or treating brain tumor, including administering caffeine and/or its analog, and/or their pharmaceutically acceptable salt, as an active ingredient, to a patient in need thereof, is provided. The method for preventing or treating brain tumor has an activity to inhibit invasion, migration, and proliferation of brain tumor cells, and thereby very effective for the prevention and treatment of brain tumor.

Abstract translation: 提供了预防和/或治疗脑肿瘤的方法，包括将咖啡因和/或其类似物和/或其药学上可接受的盐作为活性成分给予有需要的患者。 预防或治疗脑肿瘤的方法具有抑制脑肿瘤细胞侵袭，迁移和增殖的作用，从而对预防和治疗脑肿瘤非常有效。