公开(公告)号：US09766247B2

公开(公告)日：2017-09-19

申请号：US14513774

申请日：2014-10-14

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eun Joo Song ,  Hyunjung Lee ,  Eunmi Ban ,  Eunice EunKyeong Kim ,  Young Sook Yoo

IPC: G01N33/50 ,  G01N33/58 ,  G01N33/68

CPC classification number: G01N33/68 ,  G01N33/502 ,  G01N2500/02

Abstract: Provided are a method of analyzing ubiquitin-proteasome activity with respect to a target polypeptide and a method of screening a ubiquitin-proteasome inhibitor. According to the provided methods, the pattern of lysis of a target polypeptide by a ubiquitin-proteasome in target cells may be quantitatively analyzed in a rapid and highly sensitive way, a ubiquitin-proteasome inhibitor may be screened in a rapid and highly sensitive way, and an anticancer agent and the activity thereof may be rapidly screened.

公开(公告)号：US20140242578A1

公开(公告)日：2014-08-28

申请号：US13865745

申请日：2013-04-18

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eun Joo SONG ,  Eunmi Ban

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: The present invention relates to a method for simultaneously detecting multiple miRNAs present in a sample and a kit for detecting same. According to the present invention, two or more miRNAs existing in trace amounts in a sample can be analyzed through only one measurement. The detection method of the present invention may be used for fast diagnosis of various diseases wherein miRNAs are involved, for example, cardiovascular diseases including myocardial infarction, with high accuracy.

Abstract translation: 本发明涉及同时检测样品中存在的多个miRNA的方法和用于检测样品的试剂盒。 根据本发明，可以通过仅一次测量来分析样品中痕量存在的两种或更多种miRNA。 本发明的检测方法可以用于快速诊断其中涉及miRNA的各种疾病，例如包括心肌梗死的心血管疾病，具有高精度。