公开(公告)号：US09766247B2

公开(公告)日：2017-09-19

申请号：US14513774

申请日：2014-10-14

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eun Joo Song ,  Hyunjung Lee ,  Eunmi Ban ,  Eunice EunKyeong Kim ,  Young Sook Yoo

IPC: G01N33/50 ,  G01N33/58 ,  G01N33/68

CPC classification number: G01N33/68 ,  G01N33/502 ,  G01N2500/02

Abstract: Provided are a method of analyzing ubiquitin-proteasome activity with respect to a target polypeptide and a method of screening a ubiquitin-proteasome inhibitor. According to the provided methods, the pattern of lysis of a target polypeptide by a ubiquitin-proteasome in target cells may be quantitatively analyzed in a rapid and highly sensitive way, a ubiquitin-proteasome inhibitor may be screened in a rapid and highly sensitive way, and an anticancer agent and the activity thereof may be rapidly screened.

公开(公告)号：US20150344887A1

公开(公告)日：2015-12-03

申请号：US14300590

申请日：2014-06-10

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eun Joo SONG ,  Eunice EunKyeong Kim ,  Tanuza Das

IPC: C12N15/113

CPC classification number: C12N15/1137 ,  C12N2310/14 ,  C12Y301/02015 ,  C12Y304/19012

Abstract: Disclosed herein is an siRNA that inhibits the expression of USP 15 protein and a pharmaceutical composition containing the same for preventing or treating cancers. According to the present invention, the siRNA of the present invention inhibits the expression of USP 15 protein thereby substantially inhibiting the growth and metastasis of cancer cells.

Abstract translation: 本文公开了抑制USP15蛋白质的表达的siRNA和含有该siRNA的药物组合物，用于预防或治疗癌症。 根据本发明，本发明的siRNA抑制USP15蛋白的表达，从而基本上抑制癌细胞的生长和转移。