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公开(公告)号：US09766247B2
公开(公告)日：2017-09-19
申请号：US14513774
申请日：2014-10-14
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Eun Joo Song , Hyunjung Lee , Eunmi Ban , Eunice EunKyeong Kim , Young Sook Yoo
CPC classification number: G01N33/68 , G01N33/502 , G01N2500/02
Abstract: Provided are a method of analyzing ubiquitin-proteasome activity with respect to a target polypeptide and a method of screening a ubiquitin-proteasome inhibitor. According to the provided methods, the pattern of lysis of a target polypeptide by a ubiquitin-proteasome in target cells may be quantitatively analyzed in a rapid and highly sensitive way, a ubiquitin-proteasome inhibitor may be screened in a rapid and highly sensitive way, and an anticancer agent and the activity thereof may be rapidly screened.
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2.发明申请DETECTION OF miRNA USING CAPILLARY ELECTROPHORESIS WITH LASER-INDUCED FLUORESCENCE DETECTION 审中-公开使用激光诱导荧光检测的毛细管电泳检测miRNA公开(公告)号：US20140099633A1
公开(公告)日：2014-04-10
申请号：US13682941
申请日：2012-11-21
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Eunmi BAN , Dong-Kyu Chae , Eun Joo Song
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q1/6816 , C12Q2600/158 , C12Q2600/178 , C12Q2525/207 , C12Q2565/629
Abstract: Disclosed is a method for detecting a miRNA present in a sample in trace amounts and a kit for detecting the same. According to the present invention, the miRNA present in the sample in trace amounts can be quantitatively analyzed in short time. The detection method of the present invention may be used for fast diagnosis of various diseases wherein miRNAs are involved, for example, cardiovascular diseases including myocardial infarction.
Abstract translation: 公开了一种用于检测微量样品中存在的miRNA的方法和用于检测其的试剂盒。 根据本发明，可以在短时间内定量分析存在于微量样品中的miRNA。 本发明的检测方法可用于快速诊断涉及miRNA的各种疾病，例如包括心肌梗死的心血管疾病。
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3.发明授权siRNA for inhibition of OTUB1 expression and pharmaceutical composition containing the same 有权用于抑制OTUB1表达的siRNA和含有其的药物组合物公开(公告)号：US08748592B1
公开(公告)日：2014-06-10
申请号：US13760271
申请日：2013-02-06
Applicant: Korea Institute of Science and Technology
Inventor： Eun Joo Song , Hyunjung Lee
IPC: C07H21/04 , A61K48/00 , C12N15/113
CPC classification number: C12N15/1137 , C12N2310/14 , C12Y304/00
Abstract: The present invention relates to an siRNA inhibiting expression of the OTUB1 protein and a composition for preventing or treating cancer containing same as an active ingredient. In accordance with the present invention, cancer cell growth can be remarkably inhibited by inhibiting OTUB1 expression using the siRNA of the present invention.
Abstract translation: 本发明涉及抑制OTUB1蛋白的表达的siRNA和用于预防或治疗含有其的作为活性成分的癌症的组合物。 根据本发明，通过使用本发明的siRNA抑制OTUB1表达，可以显着抑制癌细胞生长。
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