公开(公告)号：US20180148459A1

公开(公告)日：2018-05-31

申请号：US15821962

申请日：2017-11-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Ho Jong YOON ,  In Jae SHIN ,  Yun Ju NAM ,  Hwan Geun CHOI

IPC: C07D495/04 ,  A61P35/00

CPC classification number: C07D495/04 ,  A61P35/00

Abstract: The present invention relates to a novel 4-((2-acrylamidophenyl)amino)thieno[3,2-d]pyrimidine-7-carboxamide compound, an anticancer agent containing the compound as an active ingredient and an intermediate compound for preparing the compound.

公开(公告)号：US20230120564A1

公开(公告)日：2023-04-20

申请号：US17794314

申请日：2020-07-14

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Chan Sun PARK ,  Seung Hye CHOI ,  Han Na CHO ,  Sandip SENGUPTA ,  In Jae SHIN ,  Woo Young HUR ,  Jayprakash Narayan KUMAR

IPC: C07D471/04

Abstract: The present invention relates to a pyrido[[3,4-d]pyrimidine derivative compound showing excellent anti-proliferative efficacy against cancer cells, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, a production method therefor, a pharmaceutical composition for preventing, alleviating, or treating cancer metastasis and proliferative diseases containing the same as an active ingredient, and an anticancer composition for cancer cells. The compound exhibits excellent inhibitory activity and anti-proliferative efficacy against cancer cells, and thus the compound is useful not only for inhibiting cancer cells, but also for preventing cancer metastasis and proliferative diseases or for treating cancer.

公开(公告)号：US20220135559A1

公开(公告)日：2022-05-05

申请号：US17431591

申请日：2020-02-17

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： TAE BO SIM ,  Woo Young HUR ,  Chi Man SONG ,  Sandip SENGUPTA ,  Chan Sun PARK ,  Seung Hye CHOI ,  Han Na CHO ,  In Jae SHIN

IPC: C07D471/04

Abstract: The present disclosure relates to a pyrido[3,4-d]pyrimidin-8-one derivative compound exhibiting excellent anti-proliferative effects against cancer cells, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, a production method therefor, a pharmaceutical composition for preventing, alleviating or treating cancer metastasis and proliferative disease containing the same as an active ingredient, and an anticancer composition against cancer cells. The compound exhibits excellent cancer cell inhibitory activity and anti-proliferative effects, and thus is effective in inhibiting cancer cells, preventing cancer metastasis and proliferative diseases or treating cancer.