公开(公告)号：US20180065969A1

公开(公告)日：2018-03-08

申请号：US15672987

申请日：2017-08-09

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Han Na CHO ,  Eun Hye JU ,  Woo Young HUR ,  Ho Jong YOON ,  Chi Man SONG

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention provides a therapeutic agent of acute myeloid leukemia containing a 1,3,7-trisubstituted 3,4-dihydropyrimido[4,5-d]pyrimidine-2(1H)-one compound as an active ingredient, which has proliferation inhibitory activity for a human acute myeloid leukemia cell line OCI-AML3 having a NRAS mutant gene while having low inhibitory activity for wild type NRAS and has activity of inhibiting GCK and ACK1 protein kinases at the same time.

公开(公告)号：US20180050036A1

公开(公告)日：2018-02-22

申请号：US15677742

申请日：2017-08-15

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Ho Jong YOON ,  Woo Young HUR ,  Yun Ju NAM ,  Hwan Geun CHOI

IPC: A61K31/506

CPC classification number: A61K31/506 ,  A61K31/519 ,  A61K31/5377

Abstract: The present invention relates to a therapeutic agent for chronic myelogenous leukemia with reduced drug-resistance and side-effects containing a 1,6-disubstituted indole compound.

公开(公告)号：US20180065970A1

公开(公告)日：2018-03-08

申请号：US15674023

申请日：2017-08-10

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Woo Young HUR ,  Ho Jong YOON ,  Chi Man SONG ,  Eun Hye JU ,  Han na CHO ,  Hwan Geun CHOI

IPC: C07D487/04 ,  C07D401/14 ,  C07D403/14

CPC classification number: C07D487/04 ,  A61K31/519 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14

Abstract: The present invention provides a pharmaceutical composition, as an effective ingredient, a urea compound having a protein kinase inhibitory activity and containing a 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one skeleton, and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20160145240A1

公开(公告)日：2016-05-26

申请号：US14947204

申请日：2015-11-20

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Ho Jong YOON ,  Ji Hye YOON ,  Woo Young HUR ,  Eun Joo ROH ,  Yeon Ui KWAK

IPC: C07D403/04 ,  C07D471/04 ,  C07D487/04 ,  C07D401/14

CPC classification number: C07D403/04 ,  C07D401/14 ,  C07D471/04 ,  C07D487/04

Abstract: A heteroarylamine compound includes protein kinase inhibition activity, a pharmaceutically acceptable salt thereof and a pharmaceutical composition for preventing and treating a disease caused by abnormal cell growth, which contains the compound as an active ingredient.

Abstract translation: 杂芳基胺化合物包括蛋白激酶抑制活性，其药学上可接受的盐和用于预防和治疗由异常细胞生长引起的疾病的药物组合物，其含有该化合物作为活性成分。

公开(公告)号：US20190135765A1

公开(公告)日：2019-05-09

申请号：US16090072

申请日：2017-03-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY

Inventor： Tae Bo SIM ,  Woo Young HUR ,  Ho Jong YOON ,  Chi Man SONG ,  In Jae SHUN ,  Byeong Yun LIM ,  HanNa CHO ,  Seung Hye CHOI ,  Gu KONG ,  Jeong Yeon LEE

IPC: C07D239/42 ,  A61P35/00 ,  C07D405/12 ,  C07D409/12 ,  C07D403/12

Abstract: The present invention relates to a novel pyrimidine-4-carboxylic acid derivative having an anticancer activity, and the compound of the present invention is useful as a drug for treating and preventing tumor diseases.

公开(公告)号：US20180148459A1

公开(公告)日：2018-05-31

申请号：US15821962

申请日：2017-11-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Ho Jong YOON ,  In Jae SHIN ,  Yun Ju NAM ,  Hwan Geun CHOI

IPC: C07D495/04 ,  A61P35/00

CPC classification number: C07D495/04 ,  A61P35/00

Abstract: The present invention relates to a novel 4-((2-acrylamidophenyl)amino)thieno[3,2-d]pyrimidine-7-carboxamide compound, an anticancer agent containing the compound as an active ingredient and an intermediate compound for preparing the compound.