公开(公告)号：US20180148459A1

公开(公告)日：2018-05-31

申请号：US15821962

申请日：2017-11-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Ho Jong YOON ,  In Jae SHIN ,  Yun Ju NAM ,  Hwan Geun CHOI

IPC: C07D495/04 ,  A61P35/00

CPC classification number: C07D495/04 ,  A61P35/00

Abstract: The present invention relates to a novel 4-((2-acrylamidophenyl)amino)thieno[3,2-d]pyrimidine-7-carboxamide compound, an anticancer agent containing the compound as an active ingredient and an intermediate compound for preparing the compound.

公开(公告)号：US20180065970A1

公开(公告)日：2018-03-08

申请号：US15674023

申请日：2017-08-10

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Woo Young HUR ,  Ho Jong YOON ,  Chi Man SONG ,  Eun Hye JU ,  Han na CHO ,  Hwan Geun CHOI

IPC: C07D487/04 ,  C07D401/14 ,  C07D403/14

CPC classification number: C07D487/04 ,  A61K31/519 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14

Abstract: The present invention provides a pharmaceutical composition, as an effective ingredient, a urea compound having a protein kinase inhibitory activity and containing a 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one skeleton, and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20180050036A1

公开(公告)日：2018-02-22

申请号：US15677742

申请日：2017-08-15

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Ho Jong YOON ,  Woo Young HUR ,  Yun Ju NAM ,  Hwan Geun CHOI

IPC: A61K31/506

CPC classification number: A61K31/506 ,  A61K31/519 ,  A61K31/5377

Abstract: The present invention relates to a therapeutic agent for chronic myelogenous leukemia with reduced drug-resistance and side-effects containing a 1,6-disubstituted indole compound.