公开(公告)号：US20170298011A1

公开(公告)日：2017-10-19

申请号：US15516395

申请日：2015-09-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ki Duk PARK ,  ChangJoon Justin LEE ,  Dong Jin KIM ,  Ae Nim PAE ,  Hyun Ah CHOO ,  Sun Joon MIN ,  Yong Koo KANG ,  Yun Kyung KIM ,  Hyo Jung SONG ,  Ji Won CHOI ,  Min Ho NAM ,  Jun Young HEO ,  Seul Ki YEON ,  Bo Ko JANG ,  Eun Ji JU ,  Seon Mi JO ,  Jong-Hyun PARK

IPC: C07C237/06 ,  C07C231/12

Abstract: The present disclosure relates to an α-aminoamide derivative compound and a pharmaceutical composition containing the same. According to various embodiments of the present disclosure, provided is a therapeutic agent which can overcome the disadvantages of existing drugs used as a MAO-B inhibitor and, specifically, reversibly inhibits MAO-B through a non-covalent bond so as to alleviate or eliminate the side effects of the existing drugs which exhibit a therapeutic effect by irreversibly acting via a covalent bond with MAO-B. Particularly, a new compound having superior stability and efficacy compared to the existing reversible MAO-B inhibitors may be provided.