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    MICRO PROBE AND MANUFACTURING METHOD THEREOF
    3.
    发明申请
    MICRO PROBE AND MANUFACTURING METHOD THEREOF 有权
    微探针及其制造方法

    公开(公告)号：US20130123599A1

    公开(公告)日：2013-05-16

    申请号：US13670957

    申请日：2012-11-07

    申请人： Korea Institute of Science and Technology

    发明人： Il Joo CHO ,  Eui Sung YOON ,  Jei Won CHO ,  Myoung Gun JEON ,  Yun Kyung KIM

    IPC分类号： A61B5/0478

    CPC分类号： A61B5/0478 ,  A61B5/6868 ,  A61B2503/40 ,  A61B2503/42 ,  A61B2562/125 ,  A61B2562/18

    摘要： The micro probe according to an embodiment of the present disclosure includes: a probe portion made of a rigid material and serving as a portion inserted into the brain; a flexible portion connected to a distal end of the probe portion and made of a flexible material; a soluble portion coated on at least one surface of the flexible portion and made of a material which is dissolved by a solution in the cranium; and a body portion connected to the other end of the flexible portion whose one end is connected to the probe portion.

    摘要翻译： 根据本公开的实施例的微型探针包括：由刚性材料制成并用作插入脑中的部分的探针部分; 柔性部分，其连接到探针部分的远端并由柔性材料制成; 所述可溶部分涂覆在所述柔性部分的至少一个表面上，并且由溶液溶解在所述颅骨中的材料制成; 以及主体部分，其连接到柔性部分的另一端，其一端连接到探针部分。

    A PAIR OF AMINO ACID SEQUENCES FOR MONITORING FORMATION OF TDP-43 OLIGOMER IN LIVING CELLS VIA BIMOLECULAR FLUORESCENCE COMPLEMENTATION
    5.
    发明申请
    A PAIR OF AMINO ACID SEQUENCES FOR MONITORING FORMATION OF TDP-43 OLIGOMER IN LIVING CELLS VIA BIMOLECULAR FLUORESCENCE COMPLEMENTATION 审中-公开

    公开(公告)号：US20200340001A1

    公开(公告)日：2020-10-29

    申请号：US16857089

    申请日：2020-04-23

    申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

    发明人： Sung Su LIM ,  Seul Gi SHIN ,  Yun Kyung KIM

    IPC分类号： C12N15/64 ,  C07K14/47

    摘要： The present disclosure relates to a vector pair for screening TDP-43 (TAR DNA-binding protein 43 or TransActive Response DNA-binding protein 43) oligomer formation, a cell line transfected with the vector pair, and a method of monitoring TDP-43 oligomer formation using the cell line. More specifically, the vector pair includes: a first vector including a first TDP-43 gene and a first fluorescence protein gene; and a second vector including a second TDP-43 gene and a second fluorescence protein gene, wherein a protein expressed from the first fluorescence protein gene and a protein expressed from the second fluorescence protein gene bind to each other to display fluorescence, by association between a protein expressed from the first TDP-43 gene and a protein expressed from the second TDP-43 gene. The vector pair is effective in that it makes it possible to monitor TDP-43 oligomer formation in living cells.