公开(公告)号：US20140343295A1

公开(公告)日：2014-11-20

申请号：US14013487

申请日：2013-08-29

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Ghil Soo NAM ,  Kyung Il CHOI ,  Ae Nim PAE ,  Seon Hee SEO ,  Hyun Ah CHOO ,  Gyo Chang KEUM ,  Jung Hyun KIM

IPC分类号： C07D403/12

CPC分类号： C07D403/12 ,  A61K31/4155

摘要： The present invention relates to a 6-pyrazolylamido-3-substituted azabicyclo[3.1.0]hexane derivatives useful as calcium channel blockers, pharmaceutically acceptable salts thereof and medical use of the calcium channel inhibiting effect of the compounds for treatment of diseases.

摘要翻译： 本发明涉及可用作钙通道阻滞剂的6-吡唑基氨基-3-取代的氮杂双环[3.1.0]己烷衍生物，其药学上可接受的盐，以及该化合物治疗疾病的钙通道抑制作用的医学用途。

公开(公告)号：US20210255203A1

公开(公告)日：2021-08-19

申请号：US17021438

申请日：2020-09-15

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Ghil Soo NAM ,  Hyun Ah CHOO ,  Ahmed A. Elbatrawy ,  Gyo Chang KEUM ,  Yun Kyung KIM ,  Sung Su LIM ,  Jae Kyun LEE ,  Eun Kyoung BANG

IPC分类号： G01N33/68 ,  C07D215/20 ,  C07D401/06

摘要： Disclosed are a compound with near-infrared fluorescence that selectively binds to tau aggregates, a method for preparing the same, a tau-targeting near-infrared fluorescent probe including the compound, a composition for detecting a tau fiber protein containing the near-infrared fluorescent probe as an active ingredient, and the use of the composition for the diagnosis of tauopathy. In particular, the compound does not bind to an amyloid beta protein and has high selectivity to a tau aggregate, specifically reported as an etiology of the initial state of tauopathy, thus being useful as a near-infrared fluorescent detector for detecting a tau fiber protein for early diagnosis of a tauopathy including Alzheimer's disease.

公开(公告)号：US20170298011A1

公开(公告)日：2017-10-19

申请号：US15516395

申请日：2015-09-24

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Ki Duk PARK ,  ChangJoon Justin LEE ,  Dong Jin KIM ,  Ae Nim PAE ,  Hyun Ah CHOO ,  Sun Joon MIN ,  Yong Koo KANG ,  Yun Kyung KIM ,  Hyo Jung SONG ,  Ji Won CHOI ,  Min Ho NAM ,  Jun Young HEO ,  Seul Ki YEON ,  Bo Ko JANG ,  Eun Ji JU ,  Seon Mi JO ,  Jong-Hyun PARK

IPC分类号： C07C237/06 ,  C07C231/12

摘要： The present disclosure relates to an α-aminoamide derivative compound and a pharmaceutical composition containing the same. According to various embodiments of the present disclosure, provided is a therapeutic agent which can overcome the disadvantages of existing drugs used as a MAO-B inhibitor and, specifically, reversibly inhibits MAO-B through a non-covalent bond so as to alleviate or eliminate the side effects of the existing drugs which exhibit a therapeutic effect by irreversibly acting via a covalent bond with MAO-B. Particularly, a new compound having superior stability and efficacy compared to the existing reversible MAO-B inhibitors may be provided.