公开(公告)号：US20180353648A1

公开(公告)日：2018-12-13

申请号：US15800436

申请日：2017-11-01

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Young Mee JUNG ,  Soo Hyun KIM ,  Yoo Jin SEO

IPC: A61L27/36 ,  A61L27/52 ,  A61L27/24

CPC classification number: A61L27/3687 ,  A61L27/24 ,  A61L27/26 ,  A61L27/3625 ,  A61L27/3691 ,  A61L27/52 ,  C12Y301/00 ,  C12Y304/23001 ,  C12Y304/23002 ,  C08L89/00

Abstract: A method for preparing a decellularized tissue-based hydrogel with maximized ability of preserving various tissue-derived proteins, growth factors and cytokines by using a supercritical fluid-organic solvent system through (a) a step of decellularizing a biological tissue by bringing the same to contact with a supercritical fluid and an organic solvent at the same time; (b) a step of washing the decellularized tissue; (c) a step of preparing a decellularized tissue solution by mixing the washed decellularized tissue with one selected from an enzyme solution, an acidic solution and a mixture thereof; (d) a step of titrating the decellularized tissue solution to pH 5.5-7.8 by treating with a basic solution; and (e) a step of allowing the titrated decellularized tissue solution to stand at 30-40° C. and utilizing the same as a tissue engineering material with improved angiogenesis and tissue regeneration abilities.

公开(公告)号：US20180344489A1

公开(公告)日：2018-12-06

申请号：US15716620

申请日：2017-09-27

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Soo Hyun KIM ,  Young Mee JUNG ,  Seung Hyuk IM

IPC: A61F2/91 ,  A61L31/14 ,  A61L31/06

Abstract: A biodegradable stent and a method for preparing the same, which more particularly relate to a technology of preparing a biodegradable stent with improved flexibility and mechanical strength. The method includes a step of solid-state drawing a biodegradable filament and a step of shaping and then annealing the drawn biodegradable filament.

公开(公告)号：US20230142889A1

公开(公告)日：2023-05-11

申请号：US17980846

申请日：2022-11-04

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Young Mee JUNG ,  Inchan YOUN

IPC: C08L67/04

CPC classification number: C08L67/04

Abstract: The present disclosure relates to a biodegradable polymer-gelatin hydrogel composite, a method for preparing the same and a medical implant including the biodegradable polymer-gelatin hydrogel composite. The multi-layered biodegradable polymer-gelatin hydrogel composite of the present disclosure, wherein the biodegradable polymer membrane of a 3D reticular structure and the gelatin hydrogel are stacked, has superior durability and resilience and may exhibit improved elasticity and swellability upon wetting under hydration environment. In addition, it can be shrunk down to 50% of its initial volume upon drying and can maintain elasticity even after the shrinkage. Furthermore, when used in a medical implant, it can protect the joint from the frictional environment in the body, reinforce the muscle torn or ruptured by trauma, relive pain by maintaining space, and induce the improvement of symptoms.

公开(公告)号：US20210301241A1

公开(公告)日：2021-09-30

申请号：US17081723

申请日：2020-10-27

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Young Mee JUNG ,  Soo Hyun KIM ,  Justin Jihong CHUNG ,  Jin YOO ,  Tae Hee KIM

IPC: C12M1/00

Abstract: Provided are a method for fabricating a highly elastic porous polymer membrane, a method for manufacturing a cell culture system using a porous polymer membrane fabricated by the fabrication method, and a cell culture system manufactured by the manufacturing method. The porous polymer membrane can be fabricated by spin coating a mixture solution containing a biodegradable elastomeric polymer and a water-soluble moisture absorbent in an optimum ratio while maintaining a high relative humidity. The porous polymer membrane has a uniform thickness and a uniform pore size and is highly elastic. In addition, the thickness and pore size of the porous polymer membrane can be controlled. The porous polymer membrane can induce active cell-cell interaction during cell co-culture due to its high porosity. The porous polymer membrane enables control over cell alignment or array due to its high biocompatibility and elasticity. The porous polymer membrane can be utilized in a platform for inducing stem cell differentiation, a lab-on-a-chip, a synthetic skin simulant platform, etc.

公开(公告)号：US20180179331A1

公开(公告)日：2018-06-28

申请号：US15717212

申请日：2017-09-27

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Soo Hyun KIM ,  Young Mee JUNG ,  Seung Hyuk IM

IPC: C08G63/08

CPC classification number: C08G63/08 ,  G01N25/4866

Abstract: Disclosed is a method for preparing a poly(L-lactic acid) composite. According to the method, PLLA can be processed without losing its physical properties during thermal processing and can be effectively used to manufacture a final product with improved thermal properties. In addition, the monomer is not thermally decomposed during high-temperature polymerization. Therefore, the poly(L-lactic acid) composite can be prevented from browning. Also disclosed is a poly(L-lactic acid) composite prepared by the method.