公开(公告)号：US20150362480A1

公开(公告)日：2015-12-17

申请号：US14513774

申请日：2014-10-14

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eun Joo SONG ,  Hyunjung LEE ,  Eunmi BAN ,  Eunice EunKyeong KIM ,  Young Sook YOO

IPC: G01N33/50 ,  G01N33/58

CPC classification number: G01N33/68 ,  G01N33/502 ,  G01N2500/02

Abstract: Provided are a method of analyzing ubiquitin-proteasome activity with respect to a target polypeptide and a method of screening a ubiquitin-proteasome inhibitor. According to the provided methods, the pattern of lysis of a target polypeptide by a ubiquitin-proteasome in target cells may be quantitatively analyzed in a rapid and highly sensitive way, a ubiquitin-proteasome inhibitor may be screened in a rapid and highly sensitive way, and an anticancer agent and the activity thereof may be rapidly screened.

Abstract translation: 提供了一种分析相关靶多肽的泛素 - 蛋白酶体活性的方法和筛选泛素 - 蛋白酶体抑制剂的方法。 根据提供的方法，可以以快速和高度敏感的方式定量分析目标细胞中泛素 - 蛋白酶体的目标多肽的裂解模式，可以以快速和高度敏感的方式筛选泛素 - 蛋白酶体抑制剂， 并且可以快速筛选抗癌剂并且其活性。

公开(公告)号：US20160280741A1

公开(公告)日：2016-09-29

申请号：US14849755

申请日：2015-09-10

Applicant: Korea Institute of Science and Technology

Inventor： Min PARK ,  Min-Jung KANG ,  Byung Hwa JUNG ,  Young Sook YOO

IPC: C07K7/56 ,  G01N33/564

CPC classification number: C07K7/56 ,  C07K14/4713 ,  G01N33/564 ,  G01N33/577 ,  G01N33/6803 ,  G01N2440/18 ,  G01N2800/102

Abstract: Rheumatoid arthritis is efficiently diagnosed with improved patient's convenience using a rheumatoid arthritis diagnosis composition and a kit, each including cyclic citrullinated peptide (CCP), a rheumatoid arthritis diagnosis method using the CCP, the rheumatoid arthritis diagnosis composition, or the kit, a method of obtaining information for rheumatoid arthritis diagnosis, and a method of screening a novel diagnostic marker for rheumatoid arthritis.

Abstract translation: 使用类风湿性关节炎诊断组合物和试剂盒，有效地诊断类风湿性关节炎，其包括环瓜氨酸肽（CCP），使用CCP的类风湿性关节炎诊断方法，类风湿性关节炎诊断组合物或试剂盒， 获得类风湿关节炎诊断的信息，以及筛选类风湿性关节炎新型诊断标记物的方法。